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AHRQ Research Studies
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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
Results
1 to 12 of 12 Research Studies DisplayedMiller ME, Rahim MQ, Coven SL
Pediatric hematology and oncology physician and nurse practitioner views of the HPV vaccine and barriers to administration.
This study’s goal was to examine provider views regarding HPV vaccination for pediatric survivors of cancer and pediatric patients with sickle cell disease. The authors conducted qualitative interviews with 20 pediatric hematology/oncology physicians and nurse practitioners. They found that 90% of interviewees support HPV vaccination in their population. The number of providers who reported that they counsel about HPV or provide HPV vaccination was 45%, even in stem cell and sickle cell clinics, where other childhood vaccines are commonly provided. Clinicians identified provider-level, clinic-level, and system-level barriers to giving the HPV vaccination, that included but was not limited to time/flow constraints, lack of resources, and continued education regarding the HPV vaccine.
AHRQ-funded; HS026390.
Citation: Miller ME, Rahim MQ, Coven SL .
Pediatric hematology and oncology physician and nurse practitioner views of the HPV vaccine and barriers to administration.
Hum Vaccin Immunother 2023 Aug 1; 19(2):2224089. doi: 10.1080/21645515.2023.2224089..
Keywords: Vaccination, Sexual Health, Infectious Diseases, Prevention, Provider: Clinician, Provider: Physician
Glenn BA, Crespi CM, Herrmann AK
Effectiveness and feasibility of three types of parent reminders to increase adolescent human papillomavirus (HPV) vaccination.
Efforts to boost human papillomavirus (HPV) vaccination rates among adolescents have seen moderate success with the use of parent notifications. Nonetheless, there is limited research on the comparative efficacy and practicality of various HPV reminder methods in settings with restricted resources. The purpose of this quasi-experimental study (2016-2017) assessed the impact of three types of parent reminders (written correspondence, automated phone calls, and SMS messages) on HPV vaccine uptake for the subsequent dose among 12-year-olds at a prominent Federally Qualified Health Center in Los Angeles County. The researchers matched six clinics into three groups, randomly allocating one clinic from each group to either intervention or control. The intervention clinics were randomly assigned one of the three reminder methods. The researchers determined the rates of vaccine uptake for the next dose and analyzed intervention outcomes using logistic regression models. The proportion of successfully delivered reminders for each method was used as a measure of feasibility. The study included 877 12-year-olds due for an HPV vaccine dose (47% female, more than 85% Latino). The study found that after a 4-month follow-up, 23% of those in the intervention group received an HPV vaccine dose, compared to just 12% in the control group. Overall, receiving any reminder led to higher rates of the next-required HPV vaccine compared to standard care (p = 0.046). Notable improvements were seen with SMS reminders (p = 0.036) and among boys (p = 0.006). Automated phone calls proved to be the least feasible method. Text message reminders are both effective and practical in encouraging HPV vaccination.
AHRQ-funded; HS000044
Citation: Glenn BA, Crespi CM, Herrmann AK .
Effectiveness and feasibility of three types of parent reminders to increase adolescent human papillomavirus (HPV) vaccination.
Prev Med 2023 Apr;169:107448. doi: 10.1016/j.ypmed.2023.107448.
Keywords: Children/Adolescents, Vaccination, Sexual Health
Glenn BA, Nonzee NJ, Herrmann AK
Impact of a multi-level, multi-component, system intervention on HPV vaccination in a federally qualified health center.
This paper evaluates the effectiveness of a multi-component, system-level intervention to improve human papillomavirus (HPV) vaccination rates in Federally Qualified Health Center (FQHC) clinics. The eight participating clinics were randomly assigned to study condition (four intervention, four usual care) that serve a primarily low-income Latino population. The intervention included parent reminders for HPV vaccine series completion, provider training, clinic-level audit and feedback, and workflow modifications to reduce missed opportunities for vaccination. The authors compared HPV vaccination rates among patients, ages 11 to 17 during a 12-month preintervention period and a 15-month intervention period. There was a greater increase in vaccination completion rates among boys, but not girls.
AHRQ-funded; HS000046.
Citation: Glenn BA, Nonzee NJ, Herrmann AK .
Impact of a multi-level, multi-component, system intervention on HPV vaccination in a federally qualified health center.
Cancer Epidemiol Biomarkers Prev 2022 Oct 4;31(10):1952-58. doi: 10.1158/1055-9965.Epi-22-0156..
Keywords: Infectious Diseases, Sexual Health, Vaccination
Bastani R, Glenn BA, Singhal R
Increasing HPV vaccination among low-income, ethnic minority adolescents: effects of a multicomponent system intervention through a county health department hotline.
The human papillomavirus (HPV) vaccine has cancer prevention benefits, yet low uptake. The purpose of the study was to evaluate an intervention intended to improve vaccine uptake in low-income, ethnic minority adolescents using a telephone hotline to seek county health department services. The researchers recruited participants through randomization of health department hotline callers who were caregivers of never-vaccinated adolescents aged 11-17. The intervention included multi-lingual print and telephone education and personalized referral to a low cost or free provider of vaccines. Participants completed baseline, 3-month, and 9-month telephone surveys. The study found that by the end of the 9-month follow up period, the HPV vaccination rates had increased, however there were no differences between the intervention (45%) and control (42%) groups. The researchers also observed significant improvements in perceived HPV knowledge, perceived HPV risk, and barriers to vaccination. The study concluded that the county hotline intervention did not produce a greater increase in HPV vaccine rates in the intervention group than the group without the intervention. The study authors recommend that future studies should evaluate interventions which are more intensive and address accessing and using services in complex, safety net settings. The authors also noted that because 44% of unvaccinated adolescents in both the intervention and control groups received at least one dose of the vaccine during the study period, investigators of future studies should be aware of the potential priming effects of participation in the study, which may impact the results of interventions.
AHRQ-funded; HS000046.
Citation: Bastani R, Glenn BA, Singhal R .
Increasing HPV vaccination among low-income, ethnic minority adolescents: effects of a multicomponent system intervention through a county health department hotline.
Cancer Epidemiol Biomarkers Prev 2022 Jan;31(1):175-82. doi: 10.1158/1055-9965.Epi-20-1578..
Keywords: Children/Adolescents, Vaccination, Low-Income, Racial and Ethnic Minorities, Sexual Health, Prevention
Glenn BA, Nonzee NJ, Tieu L
Human papillomavirus (HPV) vaccination in the transition between adolescence and adulthood.
This study looked at the barriers to human papillomavirus (HPV) vaccination among young adults receiving care at the student health center of a large public university. The authors conducted semi-structured interviews (n=27) and four focus groups with undergraduate and graduate students (n=18) and semi-structured interviews with 6 health care providers. The interviews and focus groups explored perceived risk of HPV infection, benefits of the HPV vaccine, and motivations for and barriers to HPV vaccination. Many students cited their parents’ views and recommendations from their medical providers as influential on their decision-making process. Cervical cancer prevention was considered the main benefit of the HPV vaccine and sexual activity was a risk factor for HPV infection. Students often lacked knowledge about the vaccine’s benefit for males. Safety and side effects of the vaccine perceived as new were also cited. Providers’ vaccine recommendations were impacted by health system factors including clinical infrastructure, office visit priorities, and processes for recommending and documentation vaccination. Providers suggested various promotion strategies including improving the timing and messaging of outreach efforts on campus and bolstering clinical infrastructure.
AHRQ-funded; HS000046.
Citation: Glenn BA, Nonzee NJ, Tieu L .
Human papillomavirus (HPV) vaccination in the transition between adolescence and adulthood.
Vaccine 2021 Jun 8;39(25):3435-44. doi: 10.1016/j.vaccine.2021.04.019..
Keywords: Young Adults, Sexual Health, Infectious Diseases, Vaccination, Prevention, Cancer: Cervical Cancer, Cancer, Women
Margolis MA, Brewer NT, Shah PD
Stories about HPV vaccine in social media, traditional media, and conversations.
To understand how stories from media and social interactions shape parents' HPV vaccination decisions, the authors sought to characterize parents' exposure to these stories, as well as associations between story exposure and vaccination behavior. They found that stories of HPV vaccine harms may be associated more strongly with vaccination behavior than stories of HPV vaccine preventable diseases. They recommended that communication campaigns consider strategies to elevate stories of preventable diseases in social and traditional media.
AHRQ-funded; HS000032.
Citation: Margolis MA, Brewer NT, Shah PD .
Stories about HPV vaccine in social media, traditional media, and conversations.
Prev Med 2019 Jan;118:251-56. doi: 10.1016/j.ypmed.2018.11.005..
Keywords: Caregiving, Children/Adolescents, Communication, Education: Patient and Caregiver, Health Promotion, Infectious Diseases, Prevention, Sexual Health, Social Media, Vaccination
Calo WA, Gilkey MB, Shah P
Parents' willingness to get human papillomavirus vaccination for their adolescent children at a pharmacy.
The researchers sought to examine parents' willingness to get human papillomavirus (HPV) vaccination for their children at pharmacies. Overall, their national survey found that 29 percent of parents would be willing to get HPV vaccine for their children at a pharmacy. Parental willingness was associated with believing that pharmacists are skilled at administering vaccines.
AHRQ-funded; HS000032.
Citation: Calo WA, Gilkey MB, Shah P .
Parents' willingness to get human papillomavirus vaccination for their adolescent children at a pharmacy.
Prev Med 2017 Jun;99:251-56. doi: 10.1016/j.ypmed.2017.02.003.
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Keywords: Children/Adolescents, Infectious Diseases, Provider: Pharmacist, Sexual Health, Vaccination
Haidari LA, Brown ST, Constenla D
Geospatial planning and the resulting economic impact of human papillomavirus vaccine introduction in Mozambique.
Researchers developed the Strategic Integrated Geo-temporal Mapping Application) to determine the potential economic impact of HPV immunization in Mozambique. If each health center covers a catchment area with a 5-km radius, then 40 percent of the target population could be reached to prevent 50 cases, 178 disability-adjusted life years, and US $202,854 in health care costs and lost productivity.
AHRQ-funded; HS023317.
Citation: Haidari LA, Brown ST, Constenla D .
Geospatial planning and the resulting economic impact of human papillomavirus vaccine introduction in Mozambique.
Sex Transm Dis 2017 Apr;44(4):222-26. doi: 10.1097/olq.0000000000000574.
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Keywords: Cancer, Healthcare Costs, Infectious Diseases, Sexual Health, Vaccination
Baldwin AS, Denman DC, Sala M
Translating self-persuasion into an adolescent HPV vaccine promotion intervention for parents attending safety-net clinics.
Researchers developed a tablet-based application (in English and Spanish) to elicit parental self-persuasion for adolescent HPV vaccination and evaluated its feasibility in a safety-net population. They found that the self-persuasion application was feasible and resulted in a change in parents' decision stage. Future studies can now test the efficacy of the tablet-based application on HPV vaccination.
AHRQ-funded; HS022418.
Citation: Baldwin AS, Denman DC, Sala M .
Translating self-persuasion into an adolescent HPV vaccine promotion intervention for parents attending safety-net clinics.
Patient Educ Couns 2017 Apr;100(4):736-41. doi: 10.1016/j.pec.2016.11.014.
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Keywords: Children/Adolescents, Health Promotion, Vaccination, Infectious Diseases, Sexual Health, Prevention
Shay LA, Street RL, Jr., Baldwin AS
Characterizing safety-net providers' HPV vaccine recommendations to undecided parents: a pilot study.
The researchers developed a tool to describe strength and content of provider HPV vaccination recommendations. The tool showed how providers undercut their recommendations through qualifications or support them with a rationale. The authors recommended that providers would benefit from communication skills training on how to make explicit recommendations with an evidence-based rationale.
AHRQ-funded; HS022418.
Citation: Shay LA, Street RL, Jr., Baldwin AS .
Characterizing safety-net providers' HPV vaccine recommendations to undecided parents: a pilot study.
Patient Educ Couns 2016 Sep;99(9):1452-60. doi: 10.1016/j.pec.2016.06.027.
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Keywords: Practice Patterns, Vaccination, Infectious Diseases, Sexual Health, Clinician-Patient Communication, Guidelines, Evidence-Based Practice, Communication
Yun H, Yang S, Chen L
Risk of herpes zoster in autoimmune and inflammatory diseases: implications for vaccination.
This study was undertaken to evaluate the age-stratified incidence of herpes zoster (HZ) in patients with autoimmune or inflammatory (AI) diseases as compared to older adults for whom the HZ vaccine is currently recommended by the US Centers for Disease Control and Prevention. The researchers found that systemic lupus erythematosus, inflammatory bowel disease, and rheumatoid arthritis are AI diseases associated with a higher risk of HZ compared to that in older adults for whom vaccination is currently recommended, suggesting that individuals with these conditions who are as young as age 40 years could potentially benefit from the HZ vaccine.
AHRQ-funded; HS021694; HS018517.
Citation: Yun H, Yang S, Chen L .
Risk of herpes zoster in autoimmune and inflammatory diseases: implications for vaccination.
Arthritis Rheumatol 2016 Sep;68(9):2328-37. doi: 10.1002/art.39670.
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Keywords: Infectious Diseases, Prevention, Arthritis, Risk, Sexual Health, Vaccination
Strohl AE, Mendoza G, Ghant MS
Barriers to prevention: knowledge of HPV, cervical cancer, and HPV vaccinations among African American women.
The overall goal of this study was to explore targetable barriers to HPV vaccination among African American women in an urban Chicago population. Most middle-aged African American women demonstrated low knowledge scores regarding HPV, cervical cancer, and the HPV vaccine. Education level, household income and having a child who had been offered the HPV vaccine were associated positively with adequate knowledge scores.
AHRQ-funded; HS021141.
Citation: Strohl AE, Mendoza G, Ghant MS .
Barriers to prevention: knowledge of HPV, cervical cancer, and HPV vaccinations among African American women.
Am J Obstet Gynecol 2015 Jan;212(1):65.e1-5. doi: 10.1016/j.ajog.2014.06.059..
Keywords: Prevention, Racial and Ethnic Minorities, Sexual Health, Urban Health, Vaccination, Women