National Healthcare Quality and Disparities Report
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AHRQ Research Studies Date
Topics
- Adverse Drug Events (ADE) (1)
- Adverse Events (1)
- Ambulatory Care and Surgery (2)
- Care Management (1)
- Children/Adolescents (5)
- Diabetes (2)
- Diagnostic Safety and Quality (1)
- Disabilities (1)
- Elderly (2)
- Family Health and History (1)
- Genetics (2)
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- Medication: Safety (1)
- Mortality (1)
- (-) Neurological Disorders (17)
- Newborns/Infants (1)
- Outcomes (2)
- Patient-Centered Outcomes Research (4)
- Patient Safety (1)
- Quality Measures (1)
- Quality of Care (1)
- Quality of Life (2)
- Racial and Ethnic Minorities (1)
- Rehabilitation (1)
- Risk (3)
- Screening (1)
- Sickle Cell Disease (1)
- Skin Conditions (1)
- Sleep Problems (1)
- Stress (1)
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AHRQ Research Studies
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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
Results
1 to 17 of 17 Research Studies DisplayedBiermacka JM, Chung SJ, Amasu SM
Genome-wide gene-environment interaction analysis of pesticide exposure and risk of Parkinson's disease.
The researchers performed the first genome-wide gene-environment interaction analysis of pesticide exposure and risk of Parkinson's disease (PD). They concluded that although no significant interactions were identified, several of the genes with suggestive evidence of gene-environment interaction effects have biological plausibility for PD risk.
AHRQ-funded; HS024057.
Citation: Biermacka JM, Chung SJ, Amasu SM .
Genome-wide gene-environment interaction analysis of pesticide exposure and risk of Parkinson's disease.
Parkinsonism Relat Disord 2016 Nov;32:25-30. doi: 10.1016/j.parkreldis.2016.08.002.
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Keywords: Genetics, Risk, Neurological Disorders
Kesselheim AS, Bykov K, Gagne JJ
Switching generic antiepileptic drug manufacturer not linked to seizures: a case-crossover study.
The researchers estimated the risk of seizure-related events associated with refilling antiepileptic drugs (AED) with generic AEDs and the effect of switching between different manufacturers of the same generic drug. They found that among patients on a generic AED, refilling the same AED was associated with an elevated risk of seizure-related event; however, there was no additional risk from switching during that refill to a different manufacturer.
AHRQ-funded; HS022193.
Citation: Kesselheim AS, Bykov K, Gagne JJ .
Switching generic antiepileptic drug manufacturer not linked to seizures: a case-crossover study.
Neurology 2016 Oct 25;87(17):1796-801. doi: 10.1212/wnl.0000000000003259.
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Keywords: Adverse Drug Events (ADE), Adverse Events, Medication, Medication: Safety, Neurological Disorders, Patient Safety, Risk
Carlozzi NE, Schilling SG, Lai JS
HDQLIFE: the development of two new computer adaptive tests for use in Huntington disease, speech difficulties, and swallowing difficulties.
The authors developed a patient-reported outcome measure for use in the Huntington Disease Health-Related Quality of Life (HDQLIFE) Measurement System that focused on the impact that difficulties with speech and swallowing have on health-related quality of life in Huntington disease. These measures may have clinical utility in other populations where speech and swallowing difficulties are prevalent.
AHRQ-funded; HS023313.
Citation: Carlozzi NE, Schilling SG, Lai JS .
HDQLIFE: the development of two new computer adaptive tests for use in Huntington disease, speech difficulties, and swallowing difficulties.
Qual Life Res 2016 Oct;25(10):2417-27. doi: 10.1007/s11136-016-1273-y.
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Keywords: Neurological Disorders, Quality of Life, Patient-Centered Outcomes Research, Health Information Technology (HIT), Quality Measures
Carmody D, Pastore AN, Landmeier KA
Patients with KCNJ11-related diabetes frequently have neuropsychological impairments compared with sibling controls.
This study compared neurodevelopmental outcomes in patients with KCNJ11 mutations and their sibling controls. It found that patients with KCNJ11-related diabetes without global developmental delay had significant differences compared with sibling controls on a range of assessments including IQ, measures of academic achievement and executive function.
AHRQ-funded; HS023007.
Citation: Carmody D, Pastore AN, Landmeier KA .
Patients with KCNJ11-related diabetes frequently have neuropsychological impairments compared with sibling controls.
Diabet Med 2016 Oct;33(10):1380-6. doi: 10.1111/dme.13159.
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Keywords: Children/Adolescents, Diabetes, Disabilities, Neurological Disorders, Newborns/Infants
Dy CJ, Baty J, Saeed MJ
A population-based analysis of time to surgery and travel distances for brachial plexus surgery.
Since the published brachial plexus injuries (BPI) experience is largely from individual centers, the authors used a population-based approach to evaluate the delivery of care for patients with BPI. They found that nearly one third of patients underwent BPI surgery more than 1 year after the injury, with patients initially treated at smaller hospitals at risk for undergoing delayed BPI surgery. These findings can inform efforts to expedite timely referral of patients with BPI to experienced centers.
AHRQ-funded; HS019455.
Citation: Dy CJ, Baty J, Saeed MJ .
A population-based analysis of time to surgery and travel distances for brachial plexus surgery.
J Hand Surg Am 2016 Sep;41(9):903-09.e3. doi: 10.1016/j.jhsa.2016.07.054.
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Keywords: Healthcare Cost and Utilization Project (HCUP), Healthcare Delivery, Surgery, Neurological Disorders
Conlon C, Asch S, Hanson M
Assessing the value of high-quality care for work-associated carpal tunnel syndrome in a large integrated health care system: study design.
The researchers described the design of a study that is assessing quality of care for work-associated carpal tunnel syndrome and associations with clinical outcomes and costs. They found that time off work was generally short and related to surgery. They recommended systematic efforts to evaluate and improve quality of medical care for this condition.
AHRQ-funded; HS018982.
Citation: Conlon C, Asch S, Hanson M .
Assessing the value of high-quality care for work-associated carpal tunnel syndrome in a large integrated health care system: study design.
Perm J 2016 Fall;20(4):87-95. doi: 10.7812/tpp/15-220.
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Keywords: Healthcare Delivery, Quality of Care, Injuries and Wounds, Neurological Disorders, Patient-Centered Outcomes Research
Senders A, Sando K, Wahbeh H
Managing psychological stress in the multiple sclerosis medical visit: patient perspectives and unmet needs.
Psychological stress can negatively impact multiple sclerosis. To further understand how stress is addressed in the multiple sclerosis medical visit, 34 people with multiple sclerosis participated in focus groups. Transcripts were analyzed by inductive thematic analysis. The majority of participants did not discuss stress with their provider, citing barriers to communication such as lack of time, poor coordination between specialties, physician reliance on pharmaceutical prescription, and patient lack of self-advocacy. Participants recommended several ways to better manage psychological well-being in the clinical setting. These findings provide a foundation for future studies aimed at minimizing the detrimental effect of stress in multiple sclerosis.
AHRQ-funded; HS017582.
Citation: Senders A, Sando K, Wahbeh H .
Managing psychological stress in the multiple sclerosis medical visit: patient perspectives and unmet needs.
J Health Psychol 2016 Aug;21(8):1676-87. doi: 10.1177/1359105314562084.
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Keywords: Care Management, Neurological Disorders, Ambulatory Care and Surgery, Stress
Gavinski K, Carnahan R, Weckmann M
Validation of the delirium observation screening scale in a hospitalized older population.
The authors studied the accuracy of the Delirium Observation Screening Scale (DOS) as a screening tool in hospitalized patients over age 64. They also investigated the user-friendliness of the tool. They determined that DOS is an accurate and easy way to screen for delirium in older inpatients.
AHRQ-funded; HS022666.
Citation: Gavinski K, Carnahan R, Weckmann M .
Validation of the delirium observation screening scale in a hospitalized older population.
J Hosp Med 2016 Jul;11(7):494-7. doi: 10.1002/jhm.2580.
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Keywords: Elderly, Hospitalization, Neurological Disorders, Screening
Crawford RD, Jonassaint CR
Adults with sickle cell disease may perform cognitive tests as well as controls when processing speed is taken into account: a preliminary case-control study.
The authors aimed to: (1) evaluate cognitive function among adults with sickle cell disease using a computer-administered neuropsychological test; and (2) replicate previously identified differences in processing speed between patients with sickle cell disease and controls.They replicated previous findings showing a greater than 10-point deficit in processing speed among patients with sickle cell disease. However, when differences in processing speed are taken into account, patients perform equally well or better than controls on cognitive tasks.
AHRQ-funded; HS022989.
Citation: Crawford RD, Jonassaint CR .
Adults with sickle cell disease may perform cognitive tests as well as controls when processing speed is taken into account: a preliminary case-control study.
J Adv Nurs 2016 Jun;72(6):1409-16. doi: 10.1111/jan.12755.
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Keywords: Neurological Disorders, Sickle Cell Disease
Naidech AM, Polnaszek KL, Berman MD
Hematoma locations predicting delirium symptoms after intracerebral hemorrhage.
The researchers tested the hypothesis that hematoma location is predictive of delirium symptoms in patients with intracerebral hemorrhage. Identifying 90 patients with intracerebral hemorrhage, they found that acute delirium symptoms were predicted by hematoma of right-hemisphere subcortical white matter and parahippocampal gyrus. The authors concluded that disruption of large-scale brain networks that normally support attention and conscious awareness was thus associated with acute delirium symptoms.
AHRQ-funded; HS023437.
Citation: Naidech AM, Polnaszek KL, Berman MD .
Hematoma locations predicting delirium symptoms after intracerebral hemorrhage.
Neurocrit Care 2016 Jun;24(3):397-403. doi: 10.1007/s12028-015-0210-1.
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Keywords: Neurological Disorders, Patient-Centered Outcomes Research, Quality of Life
Williams RC, Elston RC, Kumar P
Selecting SNPs informative for African, American Indian and European Ancestry: application to the Family Investigation of Nephropathy and Diabetes (FIND).
The researchers studied individual genetic ancestry (IGA) in four samples in the Family Investigation of Nephropathy and Diabetes (FIND). They found that the identified set of ancestry informtive markers (AIMs) may be particularly useful for estimating genetic admixture in populations from the Americas. They concluded that odds ratios for the associations of IGA with disease are consistent with what is known about the incidence and prevalence of diabetic nephropathy in these populations.
AHRQ-funded; HS008365.
Citation: Williams RC, Elston RC, Kumar P .
Selecting SNPs informative for African, American Indian and European Ancestry: application to the Family Investigation of Nephropathy and Diabetes (FIND).
BMC Genomics 2016 May 4;17:325. doi: 10.1186/s12864-016-2654-x.
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Keywords: Diabetes, Family Health and History, Genetics, Neurological Disorders, Racial and Ethnic Minorities
Ladner TR, Greenberg JK, Guerrero N
Chiari malformation type I surgery in pediatric patients. part 1: validation of an ICD-9-CM code search algorithm.
The researchers sought to validate two ICD-9-CM code algorithms using hospital billing data to identify pediatric patients undergoing Chiari malformation Type I (CM-I) decompression surgery. They found that an ICD-9-CM algorithm requiring a primary diagnosis of CM-I has excellent positive predictive value and very good sensitivity for identifying CM-I decompression surgery in pediatric patients. They concluded that these results establish a basis for utilizing administrative billing data to assess pediatric CM-I treatment outcomes.
AHRQ-funded; HS019455.
Citation: Ladner TR, Greenberg JK, Guerrero N .
Chiari malformation type I surgery in pediatric patients. part 1: validation of an ICD-9-CM code search algorithm.
J Neurosurg Pediatr 2016 May;17(5):519-24. doi: 10.3171/2015.10.peds15370.
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Keywords: Children/Adolescents, Neurological Disorders, Surgery
Strom MA, Silverberg JI
Allergic disease is associated with childhood seizures: an analysis of the 1997-2013 National Health Interview Survey.
This study examined a number of bivariate associations with caregiver-reported seizures and allergic disease. The results confirm the results of previous studies that found a positive association between allergic disease and seizures. Hay fever, eczema, and food allergy, but not asthma, are associated with history of seizures in children. Risk of seizures was more strongly associated with increased number of comorbid allergic diseases.
AHRQ-funded; HS023011.
Citation: Strom MA, Silverberg JI .
Allergic disease is associated with childhood seizures: an analysis of the 1997-2013 National Health Interview Survey.
J Allergy Clin Immunol 2016 Mar;137(3):951-3.e2. doi: 10.1016/j.jaci.2015.09.021.
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Keywords: Children/Adolescents, Neurological Disorders
Silverberg JI
Association between childhood eczema and headaches: an analysis of 19 US population-based studies.
The researchers sought to determine whether childhood eczema is associated with increased headaches and whether such association is related to fatigue or sleep disturbance. After analyzing national survey data from 401,002 children and adolescents, they found that eczema is associated with increased headaches in childhood, particularly in patients with severe disease accompanied by atopy, fatigue, and sleep disturbances.
AHRQ-funded; HS023011.
Citation: Silverberg JI .
Association between childhood eczema and headaches: an analysis of 19 US population-based studies.
J Allergy Clin Immunol 2016 Feb;137(2):492-99.e5. doi: 10.1016/j.jaci.2015.07.020.
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Keywords: Children/Adolescents, Neurological Disorders, Sleep Problems, Risk, Skin Conditions
Schlitz NK, Kaiboriboon K, Koroukian SM
Long-term reduction of health care costs and utilization after epilepsy surgery.
This study assessed long-term direct medical costs, health care utilization, and mortality following resective surgery in persons with uncontrolled epilepsy. It found that the mean direct medical cost difference between the surgical group and control group was $6,806 after risk-set matching. The incidence rate ratio of inpatient, emergency room, and outpatient utilization was lower among the surgical group in both unadjusted and adjusted analyses.
AHRQ-funded; HS000059.
Citation: Schlitz NK, Kaiboriboon K, Koroukian SM .
Long-term reduction of health care costs and utilization after epilepsy surgery.
Epilepsia 2016 Feb;57(2):316-24. doi: 10.1111/epi.13280.
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Keywords: Healthcare Costs, Healthcare Utilization, Mortality, Neurological Disorders, Outcomes, Surgery
Lyons TW, Johnson KB, Michelson KA
Yield of emergent neuroimaging in children with new-onset seizure and status epilepticus.
The purpose of this paper was to determine the yield of emergent neuroimaging among children with new-onset seizures presenting with status epilepticus. The authors found that a substantial minority of children with new-onset seizures presenting with status epilepticus have urgent or emergent intracranial pathology identified on neuroimaging and that magnetic resonance imaging is the preferred imaging modality when available and safe.
AHRQ-funded; HS000063.
Citation: Lyons TW, Johnson KB, Michelson KA .
Yield of emergent neuroimaging in children with new-onset seizure and status epilepticus.
Seizure 2016 Feb;35:4-10. doi: 10.1016/j.seizure.2015.12.009.
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Keywords: Children/Adolescents, Diagnostic Safety and Quality, Imaging, Neurological Disorders, Outcomes, Patient-Centered Outcomes Research
McDonough CM, Ni P, Coster WJ
Development of an IRT-based short form to assess applied cognitive function in outpatient rehabilitation.
The authors developed a 15-item outpatient rehabilitation self-report short form for the Activity Measure for Post-Acute Care Applied Cognition item bank. They concluded that their Applied Cognition outpatient short form demonstrated acceptable psychometric properties and provides a bridge to item response theory-based measurement when point-of-care computing is not available.
AHRQ-funded; HS021368.
Citation: McDonough CM, Ni P, Coster WJ .
Development of an IRT-based short form to assess applied cognitive function in outpatient rehabilitation.
Am J Phys Med Rehabil 2016 Jan;95(1):62-71. doi: 10.1097/phm.0000000000000340.
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Keywords: Elderly, Neurological Disorders, Ambulatory Care and Surgery, Rehabilitation