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Topics
- Behavioral Health (1)
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- Brain Injury (1)
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- Comparative Effectiveness (5)
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AHRQ Research Studies
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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
Results
1 to 21 of 21 Research Studies DisplayedBoursaw B, Oetzel JG, Dickson E
Scales of practices and outcomes for community-engaged research.
The purpose of this study was to present the psychometric properties of scales from the Engage for Equity (E2) project, stemming from a long-term research partnership examining community-engaged research projects. This study used a three-stage, cross-sectional format: (a) a sampling frame of 413 CEnR projects was identified; (b) 210 principal investigators completed a project-level survey and nominated partners for another survey; (c) 457 investigators and partners completed a survey about project contexts, processes, interventions, and outcomes.
AHRQ-funded; HS000036.
Citation: Boursaw B, Oetzel JG, Dickson E .
Scales of practices and outcomes for community-engaged research.
Am J Community Psychol 2021 Jun;67(3-4):256-70. doi: 10.1002/ajcp.12503..
Keywords: Outcomes, Research Methodologies
Keeney T, Belanger E, Jones RN
High-need phenotypes in Medicare beneficiaries: drivers of variation in utilization and outcomes.
The goal of this study was to identify distinct clinical phenotypes present within high-need Medicare beneficiaries and to examine differences in outcomes between phenotypes. Researchers identified five phenotypes and concluded that their findings represented a first step toward classifying the heterogeneity among high-need Medicare beneficiaries. They recommend further work to identify modifiable utilization patterns between phenotypes to improve the value of healthcare provided to these subpopulations.
AHRQ-funded; HS000011.
Citation: Keeney T, Belanger E, Jones RN .
High-need phenotypes in Medicare beneficiaries: drivers of variation in utilization and outcomes.
J Am Geriatr Soc 2020 Jan;68(1):70-77. doi: 10.1111/jgs.16146..
Keywords: Medicare, Research Methodologies, Outcomes, Health Services Research (HSR)
Istl AC, Ruck JM, Morris CD
Call for improved design and reporting in soft tissue sarcoma studies: a systematic review and meta-analysis of chemotherapy and survival outcomes in resectable STS.
Researchers completed a meta-analysis of chemotherapy in localized STS, assessing OS, PFS, and local and distant recurrence. They found no benefit of chemotherapy over locoregional therapy alone for all-comers or site-specific STS. Recommendations to improve outcome reporting and quality indices are suggested.
AHRQ-funded; HS024736.
Citation: Istl AC, Ruck JM, Morris CD .
Call for improved design and reporting in soft tissue sarcoma studies: a systematic review and meta-analysis of chemotherapy and survival outcomes in resectable STS.
J Surg Oncol 2019 Jun;119(7):824-35. doi: 10.1002/jso.25401..
Keywords: Cancer, Treatments, Evidence-Based Practice, Mortality, Outcomes, Research Methodologies
Millar MM, Kinney AY, Camp NJ
Predictors of response outcomes for research recruitment through a central cancer registry: evidence from 17 recruitment efforts for population-based studies.
The authors conducted multivariable mixed-effects logistic regression to identify case and study characteristics associated with making contact with and obtaining cooperation of Utah cancer cases. They found that characteristics associated with lower odds of contact included Hispanic ethnicity, nonwhite race, and younger age at contact. Years since diagnosis was inversely associated with making contact. Increased odds of cooperation were associated with including a questionnaire, postage stamps, and incentives. They concluded that obtaining high response is challenging, but study features identified in this analysis support better results when recruiting through central cancer registries.
AHRQ-funded; HS019356; HS022640.
Citation: Millar MM, Kinney AY, Camp NJ .
Predictors of response outcomes for research recruitment through a central cancer registry: evidence from 17 recruitment efforts for population-based studies.
Am J Epidemiol 2019 May;188(5):928-39. doi: 10.1093/aje/kwz011..
Keywords: Cancer, Patient-Centered Outcomes Research, Evidence-Based Practice, Registries, Outcomes, Research Methodologies
Ishimine P, Adelgais K, Barata I
Executive summary: the 2018 Academic Emergency Medicine Consensus Conference: Aligning the Pediatric Emergency Medicine Research Agenda to Reduce Health Outcome Gaps.
Emergency care providers share a compelling interest in developing an effective patient-centered, outcomes-based research agenda that can decrease variability in pediatric outcomes. The 2018 Academic Emergency Medicine Consensus Conference "Aligning the Pediatric Emergency Medicine Research Agenda to Reduce Health Outcome Gaps (AEMCC)" aimed to fulfill this role. This paper discusses the conference which convened major thought leaders and stakeholders to introduce a research, scholarship, and innovation agenda for pediatric emergency care specifically to reduce health outcome gaps.
AHRQ-funded; HS026101.
Citation: Ishimine P, Adelgais K, Barata I .
Executive summary: the 2018 Academic Emergency Medicine Consensus Conference: Aligning the Pediatric Emergency Medicine Research Agenda to Reduce Health Outcome Gaps.
Acad Emerg Med 2018 Dec;25(12):1317-26. doi: 10.1111/acem.13667..
Keywords: Implementation, Evidence-Based Practice, Patient-Centered Outcomes Research, Children/Adolescents, Emergency Department, Outcomes, Research Methodologies
Desai RJ, Wyss R, Jin Y
Extension of disease risk score-based confounding adjustments for multiple outcomes of interest: an empirical evaluation.
Use of disease risk score (DRS)-based confounding adjustment when estimating treatment effects on multiple outcomes is not well studied. In this empirical cohort study, the investigators compared dabigatran initiators and warfarin initiators with respect to risks of ischemic stroke and major bleeding in 12 sequential monitoring periods (90 days each), using data from the Truven Marketscan database (Truven Health Analytics, Ann Arbor, Michigan).
AHRQ-funded; HS022193.
Citation: Desai RJ, Wyss R, Jin Y .
Extension of disease risk score-based confounding adjustments for multiple outcomes of interest: an empirical evaluation.
Am J Epidemiol 2018 Nov;187(11):2439-48. doi: 10.1093/aje/kwy130.
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Keywords: Blood Thinners, Cardiovascular Conditions, Medication, Outcomes, Research Methodologies, Risk, Stroke
Sander AM, Lequerica AH, Ketchum JM
Race/ethnicity and retention in traumatic brain injury outcomes research: a traumatic brain injury model systems national database study.
The purpose of this study was to investigate the contribution of race/ethnicity to retention in traumatic brain injury (TBI) research at 1 to 2 years postinjury. The findings emphasized the importance of investigating retention rates separately for blacks and Hispanics rather than combining them or grouping either with other races or ethnicities. The results also suggested the need for implementing procedures to increase retention of Hispanics in longitudinal TBI research.
AHRQ-funded; HS022134.
Citation: Sander AM, Lequerica AH, Ketchum JM .
Race/ethnicity and retention in traumatic brain injury outcomes research: a traumatic brain injury model systems national database study.
J Head Trauma Rehabil 2018 Jul/Aug;33(4):219-27. doi: 10.1097/htr.0000000000000395..
Keywords: Brain Injury, Racial and Ethnic Minorities, Outcomes, Patient-Centered Outcomes Research, Research Methodologies
Horiguchi M, Tian L, Uno H
Quantification of long-term survival benefit in a comparative oncology clinical study.
The authors discuss the quantification of long-term survival benefit in a comparative oncology clinical study. They assert that from the perspective of cost-risk-benefit, using a long-term survival benefit criterion for selecting anticancer therapies may be more appropriate.
AHRQ-funded; HS022193.
Citation: Horiguchi M, Tian L, Uno H .
Quantification of long-term survival benefit in a comparative oncology clinical study.
JAMA Oncol 2018 Jun;4(6):881-82. doi: 10.1001/jamaoncol.2018.0518..
Keywords: Cancer, Comparative Effectiveness, Outcomes, Research Methodologies
Thorlacius L, Garg A, Ingram JR
Towards global consensus on core outcomes for hidradenitis suppurativa research: an update from the HISTORIC consensus meetings I and II.
This article describes the outcome of two in-person consensus meetings to create a core outcomes set (COS) for hidradenitis suppurative (HS) research. Forty-one individuals from 13 countries and 4 continents were included. The list of items discussed had been developed from patient interviews, a systematic literature review and a healthcare professional survey. Nine items were excluded and seven domains were approved which included: disease course, physical signs, HS-specific quality of life, satisfaction, symptoms, pain and global assessments.
AHRQ-funded; HS024585.
Citation: Thorlacius L, Garg A, Ingram JR .
Towards global consensus on core outcomes for hidradenitis suppurativa research: an update from the HISTORIC consensus meetings I and II.
Br J Dermatol 2018 Mar;178(3):715-21. doi: 10.1111/bjd.16093..
Keywords: Evidence-Based Practice, Health Services Research (HSR), Outcomes, Research Methodologies, Skin Conditions
Lou Y, Cao J, Zhang S
Sample size calculations for time-averaged difference of longitudinal binary outcomes.
In this study, the researchers investigated sample size calculation for the comparison of time-averaged responses between treatment groups in clinical trials with longitudinally observed binary outcomes. Their simulation showed that the nominal power and type I error are well preserved over a wide range of design parameters. The researchers believe that theirs is the first study to consider the mixture of missing patterns in sample size calculation.
AHRQ-funded; HS022418.
Citation: Lou Y, Cao J, Zhang S .
Sample size calculations for time-averaged difference of longitudinal binary outcomes.
Commun Stat Theory Methods 2017;46(1):344-53. doi: 10.1080/03610926.2014.991040.
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Keywords: Research Methodologies, Comparative Effectiveness, Outcomes
Thorlacius L, Ingram JR, Garg A
Protocol for the development of a core domain set for hidradenitis suppurativa trial outcomes.
A COS is a list of outcomes that are meant as mandatory and should be measured and reported in all clinical trials. The aim of this study is to develop a COS for the management of the chronic, inflammatory skin disease hidradenitis suppurativa (HS). An international steering group of researchers, clinicians, and a patient research partner will guide the COS development.
AHRQ-funded; HS024585.
Citation: Thorlacius L, Ingram JR, Garg A .
Protocol for the development of a core domain set for hidradenitis suppurativa trial outcomes.
BMJ Open 2017 Feb 20;7(2):e014733. doi: 10.1136/bmjopen-2016-014733.
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Keywords: Chronic Conditions, Outcomes, Research Methodologies
Fu R, Holmer HK
Change score or follow-up score? Choice of mean difference estimates could impact meta-analysis conclusions.
This study assessed the impact of using change score vs. follow-up score on the conclusions of meta-analyses. It concluded that using the change vs. the follow-up score could lead to important discrepancies in conclusions. Sensitivity analyses should be conducted to check the robustness of results to the choice of mean difference estimates.
AHRQ-funded; 290200710057I.
Citation: Fu R, Holmer HK .
Change score or follow-up score? Choice of mean difference estimates could impact meta-analysis conclusions.
J Clin Epidemiol 2016 Aug;76:108-17. doi: 10.1016/j.jclinepi.2016.01.034.
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Keywords: Research Methodologies, Data, Outcomes
Dixon BE, Whipple EC, Lajiness JM
Utilizing an integrated infrastructure for outcomes research: a systematic review.
The authors explored the ability of an integrated health information infrastructure to support outcomes research. They found that more recent publications demonstrate growing external collaborations facilitated by greater access to the infrastructure and improved opportunities to study broader disease and health outcomes. They concluded that integrated information infrastructures can stimulate learning from electronic data captured during routine clinical care but require time and collaboration to reach full potential.
AHRQ-funded; HS020909.
Citation: Dixon BE, Whipple EC, Lajiness JM .
Utilizing an integrated infrastructure for outcomes research: a systematic review.
Health Info Libr J 2016 Mar;33(1):7-32. doi: 10.1111/hir.12127.
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Keywords: Health Information Technology (HIT), Outcomes, Research Methodologies, Evidence-Based Practice
Irvin VL, Kaplan RM
AHRQ Author: Kaplan RM
Effect sizes and primary outcomes in large-budget, cardiovascular-related behavioral randomized controlled trials funded by NIH since 1980.
The authors reviewed large-budget, National Institutes of Health (NIH)-supported randomized controlled trials (RCTs) with behavioral interventions to assess (1) publication rates, (2) trial registration, (3) use of objective measures, (4) significant behavior and physiological change, and (5) effect sizes. They concludedc that behavioral trials complied with trial registration standards. Most reported a physiological benefit, but few documented morbidity or mortality benefits.
AHRQ-authored.
Citation: Irvin VL, Kaplan RM .
Effect sizes and primary outcomes in large-budget, cardiovascular-related behavioral randomized controlled trials funded by NIH since 1980.
Ann Behav Med 2016 Feb;50(1):130-46. doi: 10.1007/s12160-015-9739-7.
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Keywords: Outcomes, Cardiovascular Conditions, Research Methodologies, Behavioral Health
McCarthy IM
Putting the patient in patient reported outcomes: a robust methodology for health outcomes assessment.
Through a series of Monte Carlo simulations, this paper illustrates that reliance solely on the summary score may lead to biased estimates of incremental effects, and proposes a novel two-stage approach that allows for unbiased estimation of incremental effects. The proposed methodology essentially reverses the order of the analysis, from one of 'aggregate, then estimate' to one of 'estimate, then aggregate'.
AHRQ-funded; HS022431.
Citation: McCarthy IM .
Putting the patient in patient reported outcomes: a robust methodology for health outcomes assessment.
Health Econ 2015 Dec;24(12):1588-603. doi: 10.1002/hec.3113.
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Keywords: Patient-Centered Outcomes Research, Outcomes, Quality of Life, Research Methodologies
Dusetzina SB, Brookhart MA, Maciejewski ML
Control outcomes and exposures for improving internal validity of nonrandomized studies.
The authors review examples of control outcomes and exposures from prior studies and provide recommendations for conducting and reporting these analyses. They found that there is inconsistent terminology for these concepts, making study identification challenging. They recommend that the rigor of nonrandomized studies can be improved with inclusion of control outcomes and exposures for bias detection.
AHRQ-funded; HS023099; HS023085.
Citation: Dusetzina SB, Brookhart MA, Maciejewski ML .
Control outcomes and exposures for improving internal validity of nonrandomized studies.
Health Serv Res 2015 Oct;50(5):1432-51. doi: 10.1111/1475-6773.12279..
Keywords: Research Methodologies, Patient-Centered Outcomes Research, Outcomes
Li T, Vedula SS, Hadar N
Innovations in data collection, management, and archiving for systematic reviews.
The authors provide a step-by-step tutorial for collecting, managing, and archiving data for systematic reviews and suggest steps for developing rigorous data collection forms in the Systematic Review Data Repository to facilitate implementation of the methodological standards and expectations of the Institute of Medicine and other organizations.
AHRQ-funded; 290200710055I; 290201200012I.
Citation: Li T, Vedula SS, Hadar N .
Innovations in data collection, management, and archiving for systematic reviews.
Ann Intern Med. 2015 Feb 17;162(4):287-94. doi: 10.7326/M14-1603..
Keywords: Data, Comparative Effectiveness, Outcomes, Research Methodologies
Smith SR
AHRQ Author: Smith SR
Preface to the AHRQ supplement.
AHRQ, through its Developing Evidence to Inform Decisions about Effectiveness (DEcIDE) Research Network, sponsored this supplement to present various strategies in the design, analysis, and conduct of health outcomes studies relevant to rare diseases. The purpose of this supplement is to disseminate illustrative examples of research methods that can be applied to understand health outcomes and potentially to stimulate new patient-centered outcomes studies for rare diseases.
AHRQ-authored.
Citation: Smith SR .
Preface to the AHRQ supplement.
J Gen Intern Med 2014 Aug;29 Suppl 3:S712-3. doi: 10.1007/s11606-014-2922-x.
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Keywords: Comparative Effectiveness, Evidence-Based Practice, Outcomes, Patient-Centered Outcomes Research, Research Methodologies
Garabedian LF, Chu P, Toh S
Potential bias of instrumental variable analyses for observational comparative effectiveness research.
Results of instrumental variable analyses may be biased if the instrument and outcome are related through an unadjusted third variable, an instrument-outcome confounder. The authors review of 187 comparative effectiveness studies using this type of analysis, only 4 considered potential instrument-outcome confounders outside the study data.
AHRQ-funded; 290050016I
Citation: Garabedian LF, Chu P, Toh S .
Potential bias of instrumental variable analyses for observational comparative effectiveness research.
Ann Intern Med. 2014 Jul 15;161(2):131-8. doi: 10.7326/M13-1887..
Keywords: Comparative Effectiveness, Outcomes, Research Methodologies
Darney BG, Caughey AB
Elective induction of labor symposium: nomenclature, research methodological issues, and outcomes.
This article focuses on key method issues in studies of elective induction of labor. The authors first identify methodological concerns with the existing literature and discuss each in return. They then review existing evidence about the relationship between elective induction and cesarean delivery.
AHRQ-funded; HS017582
Citation: Darney BG, Caughey AB .
Elective induction of labor symposium: nomenclature, research methodological issues, and outcomes.
Clin Obstet Gynecol. 2014 Jun;57(2):343-62. doi: 10.1097/GRF.0000000000000029..
Keywords: Research Methodologies, Outcomes, Labor and Delivery, Women
Cappelleri JC, Lundy JJ, Hays RD
Overview of classical test theory and item response theory for the quantitative assessment of items in developing patient-reported outcomes measures.
This article presents an overview of classical test theory and item response theory in the quantitative assessment of items and scales during the content-validity phase of patient-reported outcomes (PRO) measure development. The researchers concluded that depending on the particular type of measure and specific circumstances, either approach or both may be useful to help maximize the content validity of a PRO measure.
AHRQ-funded; HS016980
Citation: Cappelleri JC, Lundy JJ, Hays RD .
Overview of classical test theory and item response theory for the quantitative assessment of items in developing patient-reported outcomes measures.
Clin Ther. 2014 May;36(5):648-662. doi: 10.1016/j.clinthera.2014.04.006..
Keywords: Outcomes, Research Methodologies