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AHRQ Research Studies
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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
Results
1 to 4 of 4 Research Studies DisplayedRuderman SA, Odden MC, Webel AR
Tobacco smoking and pack-years are associated with frailty among people with HIV.
This study examines the association of frailty with tobacco smoking and pack-years among people with HIV (PWH). The authors identified 8,608 PWH across 6 Centers for AIDS Research Network of Integrated Clinical Systems (CNICS) sites who completed ≥2 patient-reported outcome assessments, including a frailty phenotype measuring unintentional weight loss, poor mobility, fatigue, and inactivity, scored 0-4. The authors measured smoking as baseline pack-years and time-updated never, former, or current use with cigarettes/day. They used Cox models to associate smoking with risk of incident frailty (score ≥3) and deterioration (frailty score increase by ≥2 points), adjusted for demographics, antiretroviral medication, and time-updated CD4 count. Mean follow-up period of PWH was 5.3 years, the mean age at baseline was 45 years, 15% were female, and 52% were non-White. At baseline, 60% reported current or former smoking and both were associated with higher incident frailty risk, as was higher pack-years. Current smoking (among younger PWH) and pack-years were associated with higher risk of deterioration, but not former smoking.
AHRQ-funded; HS026154.
Citation: Ruderman SA, Odden MC, Webel AR .
Tobacco smoking and pack-years are associated with frailty among people with HIV.
J Acquir Immune Defic Syndr 2023 Oct 1; 94(2):135-42. doi: 10.1097/qai.0000000000003242..
Keywords: Tobacco Use, Human Immunodeficiency Virus (HIV), Chronic Conditions, Health Status
Zullo AR, Adams JW, Gantenberg JR
Examining neighborhood poverty-based disparities in HIV/STI prevalence: an analysis of Add Health data.
The purpose of the study was to estimate the effect of exposure to neighborhood poverty in adolescence on HIV/STI prevalence in early adulthood. The investigators found that strong evidence for neighborhood poverty-based differences in HIV/STI prevalence was not observed. They suggest that researchers should continue to investigate the effect of neighborhood-level socioeconomic position measures and, if warranted, identify etiologically relevant exposure periods.
AHRQ-funded; HS022998.
Citation: Zullo AR, Adams JW, Gantenberg JR .
Examining neighborhood poverty-based disparities in HIV/STI prevalence: an analysis of Add Health data.
Ann Epidemiol 2019 Nov;39:8-14.e4. doi: 10.1016/j.annepidem.2019.09.010..
Keywords: Children/Adolescents, Low-Income, Vulnerable Populations, Disparities, Social Determinants of Health, Human Immunodeficiency Virus (HIV), Infectious Diseases, Young Adults, Health Status
McKellar MS, Kuchibhatla MN, Oursler KAK
Racial differences in change in physical functioning in older male veterans with HIV.
Little is known about longitudinal change in physical functioning of older African American/Black and White HIV-infected persons. In this study, the investigators examined up to 10 years of data on African American and White men with HIV infection and comparable HIV-negative men age 50-91 years from the Veterans Aging Cohort Study Survey sample.
AHRQ-funded; HS021112; HS023464; HS023258.
Citation: McKellar MS, Kuchibhatla MN, Oursler KAK .
Racial differences in change in physical functioning in older male veterans with HIV.
AIDS Res Hum Retroviruses 2019 Nov/Dec;35(11-12):1034-43. doi: 10.1089/aid.2018.0296..
Keywords: Human Immunodeficiency Virus (HIV), Health Status, Racial and Ethnic Minorities, Elderly, Men's Health
Buscher AL, Kallen MA, Suarez-Almazor ME
Development of an "Impact of HIV" instrument for HIV survivors.
A newly created Impact of HIV Survey, modified from Zebrack's Impact of Cancer Scale, was developed and completed by 356 HIV-infected patients on antiretroviral therapy. Factor analyses confirmed seven scales within 38 items: Health Awareness, Positive Self-Evaluation, Positive Outlook, Value of Relationships, Negative Self-Evaluation-Outlook, Health Anxiety, and Body Change.
AHRQ-funded; HS016093.
Citation: Buscher AL, Kallen MA, Suarez-Almazor ME .
Development of an "Impact of HIV" instrument for HIV survivors.
J Assoc Nurses AIDS Care 2015 Nov-Dec;26(6):720-31. doi: 10.1016/j.jana.2015.08.002.
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Keywords: Human Immunodeficiency Virus (HIV), Quality of Life, Health Status