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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
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1 to 3 of 3 Research Studies DisplayedSequeria GM, Guler J, Reyes V
Adolescent and caregiver perspectives on receiving gender-affirming care in primary care.
The purpose of this study was to examine Transgender and gender-diverse (TGD) adolescents' and caregivers' experiences and perspectives about gender-affirming care delivery in pediatric primary care. Semi-structured, individual, virtual interviews were administered to TGD adolescents aged 14 to 17 and caregivers of TGD adolescents currently receiving gender-affirming medical care. A total of 15 adolescents and 18 caregivers (33 total participants) completed interviews. Adolescent participants primarily identified as transmasculine or trans male (73%), and caregiver participants were primarily mothers (83.3%). The study identified four themes, which included 1) barriers, such as microaggressions and poor psychosocial support, 2) benefits, such as existing trusted relationships with primary care providers (PCPs) and convenience, 3) improvement strategies, such as training and interdisciplinary collaboration, and 4) opportunities for integrating primary care and specialty gender-affirming care.
AHRQ-funded; HS026393.
Citation: Sequeria GM, Guler J, Reyes V .
Adolescent and caregiver perspectives on receiving gender-affirming care in primary care.
Pediatrics 2023 Oct 1; 152(4). doi: 10.1542/peds.2023-062210..
Keywords: Sex Factors, Children/Adolescents, Primary Care
Levander XA, Carmody T, Cook RR
A gender-based secondary analysis of the ADAPT-2 combination naltrexone and bupropion treatment for methamphetamine use disorder trial.
This study’s objective was to determine if there were gender-based differences in treatment for methamphetamine use disorder (MUD) in general comparing treatment with placebo and due to use of a hormonal method of contraception (HMC). This research was a secondary analysis of ADAPT-2, a randomized, double-blind, placebo-controlled, multicenter, two-stage sequential parallel comparison design trial. This cohort study comprised 126 women (403 total participants); average age of 40.1 years with moderate to severe MUD. At baseline, women used methamphetamine intravenously fewer days than men [15.4 versus 23.1% days] and more women than men had anxiety (59.5 versus 47.6%). Of the 113 women capable of becoming pregnant, 31 used HMC. Treatment response for women was 29% in Stage 1 and 5.6% in Stage 2 compared with 3.2% and 0% on placebo, respectively. A treatment effect was found independently for females and males; with no between-gender treatment effect (0.144 females versus 0.100 males). Treatment effect did not differ by HMC use (0.156 HMC versus 0.128 none).
AHRQ-funded; HS026370.
Citation: Levander XA, Carmody T, Cook RR .
A gender-based secondary analysis of the ADAPT-2 combination naltrexone and bupropion treatment for methamphetamine use disorder trial.
Addiction 2023 Jul; 118(7):1320-28. doi: 10.1111/add.16163..
Keywords: Substance Abuse, Medication, Behavioral Health, Sex Factors
Goodsmith N, Cohen AN, Pedersen ER
Predictors of functioning and recovery among men and women veterans with schizophrenia.
This study examined predictors of functioning and recovery among men and women veterans with schizophrenia in treatment at Veterans Affairs medical centers using participant surveys at baseline and one year later. The cohort included 734 men and 67 women at baseline and 604 men and 58 women one year later. They were surveyed on quality of life and functioning. Men and women did not differ significantly in baseline social support, psychiatric symptoms, or recovery. Being female predicted higher occupational functioning, while social functioning in men was inversely related to baseline symptom severity. Marriage predicted higher quality of life for women, but not for men.
AHRQ-funded; HS026407.
Citation: Goodsmith N, Cohen AN, Pedersen ER .
Predictors of functioning and recovery among men and women veterans with schizophrenia.
Community Ment Health J 2023 Jan; 59(1):110-21. doi: 10.1007/s10597-022-00979-x..
Keywords: Behavioral Health, Sex Factors