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AHRQ Research Studies
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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
Results
401 to 419 of 419 Research Studies DisplayedSmith SR
AHRQ Author: Smith SR
Preface to the AHRQ supplement.
AHRQ, through its Developing Evidence to Inform Decisions about Effectiveness (DEcIDE) Research Network, sponsored this supplement to present various strategies in the design, analysis, and conduct of health outcomes studies relevant to rare diseases. The purpose of this supplement is to disseminate illustrative examples of research methods that can be applied to understand health outcomes and potentially to stimulate new patient-centered outcomes studies for rare diseases.
AHRQ-authored.
Citation: Smith SR .
Preface to the AHRQ supplement.
J Gen Intern Med 2014 Aug;29 Suppl 3:S712-3. doi: 10.1007/s11606-014-2922-x.
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Keywords: Comparative Effectiveness, Evidence-Based Practice, Outcomes, Patient-Centered Outcomes Research, Research Methodologies
Holzer JK, Ellis L, Merritt MW
Why we need community engagement in medical research.
The aim of this article was to illustrate how community engagement can help to remedy shortfalls of community trust, participant enrollment, and uptake of research findings. After briefly describing these shortfalls, the authors considered 3 case examples that demonstrate the potential of community engagement to address each. They also discussed the ethical importance and implications of demonstrating respect for the community.
AHRQ-funded; HS017589.
Citation: Holzer JK, Ellis L, Merritt MW .
Why we need community engagement in medical research.
J Investig Med 2014 Aug;62(6):851-5. doi: 10.1097/jim.0000000000000097..
Keywords: Health Services Research (HSR), Patient-Centered Outcomes Research, Research Methodologies, Implementation
Garabedian LF, Chu P, Toh S
Potential bias of instrumental variable analyses for observational comparative effectiveness research.
Results of instrumental variable analyses may be biased if the instrument and outcome are related through an unadjusted third variable, an instrument-outcome confounder. The authors review of 187 comparative effectiveness studies using this type of analysis, only 4 considered potential instrument-outcome confounders outside the study data.
AHRQ-funded; 290050016I
Citation: Garabedian LF, Chu P, Toh S .
Potential bias of instrumental variable analyses for observational comparative effectiveness research.
Ann Intern Med. 2014 Jul 15;161(2):131-8. doi: 10.7326/M13-1887..
Keywords: Comparative Effectiveness, Outcomes, Research Methodologies
Darney BG, Caughey AB
Elective induction of labor symposium: nomenclature, research methodological issues, and outcomes.
This article focuses on key method issues in studies of elective induction of labor. The authors first identify methodological concerns with the existing literature and discuss each in return. They then review existing evidence about the relationship between elective induction and cesarean delivery.
AHRQ-funded; HS017582
Citation: Darney BG, Caughey AB .
Elective induction of labor symposium: nomenclature, research methodological issues, and outcomes.
Clin Obstet Gynecol. 2014 Jun;57(2):343-62. doi: 10.1097/GRF.0000000000000029..
Keywords: Research Methodologies, Outcomes, Labor and Delivery, Women
Keenan GM, Wilkie DJ
Integration of NNN into EHRS: how are we doing?: IJNK virtual issue.
This commentary introduces a virtual edition of IJNK, hosted on the Journal’s website. It includes six articles published in the last 20 years that provide a snapshot of efforts to integrate one or more of the standardized terminologies, NANDA-I, NOC, NIC (NNN), into electronic health records (EHRs).
AHRQ-funded; HS015054.
Citation: Keenan GM, Wilkie DJ .
Integration of NNN into EHRS: how are we doing?: IJNK virtual issue.
Int J Nurs Knowl 2014 Jun;25(2):68-9. doi: 10.1111/2047-3095.12039..
Keywords: Electronic Health Records (EHRs), Health Information Technology (HIT), Research Methodologies
Camp KM, Parisi MA, Acosta PB
AHRQ Author: Chang CS
Phenylketonuria Scientific Review Conference: state of the science and future research needs.
An NIH State-of-the-Science Conference was convened in 2012 to address new findings, particularly the use of the medication sapropterin to treat some individuals with phenylketonuria (PKU), and to develop a research agenda. An AHRQ Evidence-based Practice Center conducted a systematic review of adjuvant treatments for PKU and presented its conclusions at the conference. New drugs that are safe, efficacious, and impact a larger proportion of individuals with PKU are needed. The identification of a research agenda has facilitated the development of clinical practice guidelines by professional organizations and serves as a model for other inborn errors of metabolism.
AHRQ-authored.
Citation: Camp KM, Parisi MA, Acosta PB .
Phenylketonuria Scientific Review Conference: state of the science and future research needs.
Mol Genet Metab 2014 Jun;112(2):87-122. doi: 10.1016/j.ymgme.2014.02.013.
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Keywords: Comparative Effectiveness, Evidence-Based Practice, Guidelines, Medication, Research Methodologies
Cappelleri JC, Lundy JJ, Hays RD
Overview of classical test theory and item response theory for the quantitative assessment of items in developing patient-reported outcomes measures.
This article presents an overview of classical test theory and item response theory in the quantitative assessment of items and scales during the content-validity phase of patient-reported outcomes (PRO) measure development. The researchers concluded that depending on the particular type of measure and specific circumstances, either approach or both may be useful to help maximize the content validity of a PRO measure.
AHRQ-funded; HS016980
Citation: Cappelleri JC, Lundy JJ, Hays RD .
Overview of classical test theory and item response theory for the quantitative assessment of items in developing patient-reported outcomes measures.
Clin Ther. 2014 May;36(5):648-662. doi: 10.1016/j.clinthera.2014.04.006..
Keywords: Outcomes, Research Methodologies
Valencia V, Moghadassi M, Kriesel DR
Study of Tomography Of Nephrolithiasis Evaluation (STONE): methodology, approach and rationale.
This paper describes the rationale and methods of STONE (Study of Tomography Of Nephrolithiasis Evaluation), a pragmatic randomized comparative effectiveness trial comparing different imaging strategies for patients with suspected urolithiasis. It concluded that the detailed methodology of STONE will provide a roadmap for comparative effectiveness studies of diagnostic imaging conducted in an ED setting.
AHRQ-funded; HS019312.
Citation: Valencia V, Moghadassi M, Kriesel DR .
Study of Tomography Of Nephrolithiasis Evaluation (STONE): methodology, approach and rationale.
Contemp Clin Trials 2014 May;38(1):92-101. doi: 10.1016/j.cct.2014.03.006..
Keywords: Comparative Effectiveness, Imaging, Kidney Disease and Health, Research Methodologies
Tugwell P, Boers M, D'Agostino MA
Updating the OMERACT filter: implications of filter 2.0 to select outcome instruments through assessment of "truth": content, face, and construct validity.
Two discussion groups critically reviewed the variety of ways in which five case studies of current OMERACT Working Groups complied with the ‘Truth’ component of the Filter and what issues remained to be resolved. The case studies showed that there is broad agreement on criteria for meeting the ‘Truth’ criteria through demonstration of content, face and construct validity; however several issues were identified that the Filter Working Group will need to address.
AHRQ-funded; HS013852
Citation: Tugwell P, Boers M, D'Agostino MA .
Updating the OMERACT filter: implications of filter 2.0 to select outcome instruments through assessment of "truth": content, face, and construct validity.
J Rheumatol. 2014 May;41(5):1000-4. doi: 10.3899/jrheum.131310..
Keywords: Evidence-Based Practice, Patient-Centered Outcomes Research, Research Methodologies
Boyd CM, Kent DM
Evidence-based medicine and the hard problem of multimorbidity.
In this article on evidence-based medicine and multimorbidity, the authors discuss the issue and assert that it remains to be determined whether sustained and concentrated attention will permit investigators to address the problem of multimorbidity using the “normal science” available with the tools of EBM, or whether such attention will produce the sort of crisis that is the first prerequisite for a new paradigm.
AHRQ-funded; HS017653; HS018597.
Citation: Boyd CM, Kent DM .
Evidence-based medicine and the hard problem of multimorbidity.
J Gen Intern Med 2014 Apr;29(4):552-3. doi: 10.1007/s11606-013-2658-z..
Keywords: Evidence-Based Practice, Research Methodologies
Buckley DI, Ansari MT, Butler M
AHRQ Author: Chang CS
The refinement of topics for systematic reviews: lessons and recommendations from the Effective Health Care Program.
AHRQ convened a work group to assess approaches and develop recommendations for topic refinement for the Effective Health Care Program. They concluded that accurate, rigorous, and useful systematic reviews require well-refined topics, and the work group's guiding principles and methodological recommendations may help investigators refine topics for reviews.
AHRQ-authored.
Citation: Buckley DI, Ansari MT, Butler M .
The refinement of topics for systematic reviews: lessons and recommendations from the Effective Health Care Program.
J Clin Epidemiol 2014 Apr;67(4):425-32. doi: 10.1016/j.jclinepi.2013.10.023.
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Keywords: Comparative Effectiveness, Evidence-Based Practice, Patient-Centered Outcomes Research, Research Methodologies
Lawrence WF
AHRQ Author: Lawrence WF
Comparative effectiveness research in practice and policy for radiation oncology.
In radiation oncology, the line between comparative effectiveness research (CER) and traditional research may be blurred, but an increased emphasis on CER can help to bridge the research enterprise and clinical practice, helping to inform decision making at the patient, clinician, and policy levels.
AHRQ-authored.
Citation: Lawrence WF .
Comparative effectiveness research in practice and policy for radiation oncology.
Semin Radiat Oncol 2014 Jan;24(1):54-60. doi: 10.1016/j.semradonc.2013.09.001.
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Keywords: Comparative Effectiveness, Evidence-Based Practice, Guidelines, Policy, Research Methodologies
Miller WL, Crabtree BF, Harrison MI
AHRQ Author: Harrison MI
Integrating mixed methods in health services and delivery system research.
The authors introduced this AHRQ-sponsored issue of Health Services Research, describing the papers and briefly indicating where they fit into the emerging mixed methods mosaic. They then provided some suggestions about what may be missing and anticipated a future state of a more integrated approach to health services research and richer dialogue between researchers and those engaged in health care.
AHRQ-authored.
Citation: Miller WL, Crabtree BF, Harrison MI .
Integrating mixed methods in health services and delivery system research.
Health Serv Res 2013 Dec;48(6 Pt 2):2125-33. doi: 10.1111/1475-6773.12123.
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Keywords: Healthcare Delivery, Health Services Research (HSR), Research Methodologies
Cohen SB, Rohde F, Yu W
AHRQ Author: Cohen SB, Rohde F, Yu W
Building wave response rates in a longitudinal survey:Essential for nonsampling error reduction or last in–first out?
This study examined the implications of a reduction in targeted first-round response rates in the Medical Expenditure Panel Survey (MEPS), a national health care survey designed to produce estimates of health care utilization, expenditures, and insurance coverage. Study findings revealed nonuniform results when evaluating the capacity of alternative design strategies to achieve precision targets while simultaneously satisfying data collection budget constraints for a variety of medical care expenditure estimates.
AHRQ-authored.
Citation: Cohen SB, Rohde F, Yu W .
Building wave response rates in a longitudinal survey:Essential for nonsampling error reduction or last in–first out?
Field Methods 2013 Nov;25(4):361-87. doi: 10.1177/1525822x13507863..
Keywords: Medical Expenditure Panel Survey (MEPS), Research Methodologies
Zimring C, Jacob JT, Denham ME
http://journals.sagepub.com/doi/pdf/10.1177/193758671300701S04
The role of facility design in preventing the transmission of healthcare-associated infections: Background and conceptual framework.
This paper describes the conceptual framework and methodology used to conduct a comprehensive literature review of current evidence evaluating the role of the built environment in the transmission of healthcare-associated infections. The methodology involves a chain of transmission interventions model that is a multidisciplinary conceptualization of the interaction between pathogens and the built environment. This model facilitated a systematic literature review of a very large amount of data.
AHRQ-funded; 290201000024I.
Citation: Zimring C, Jacob JT, Denham ME .
The role of facility design in preventing the transmission of healthcare-associated infections: Background and conceptual framework.
HERD 2013 Oct;7(1 suppl):18-30.
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Keywords: Evidence-Based Practice, Quality of Care, Healthcare-Associated Infections (HAIs), Research Methodologies
Dahabreh IJ, Chung M, Kitsios GD
Survey of the methods and reporting practices in published meta-analyses of test performance: 1987 to 2009.
The researchers performed a survey of meta-analyses of test performance to describe the evolution in their methods and reporting. They found that the most common clinical areas were cardiovascular disease and oncology, while the most common test categories were imaging and biomarker tests. They concluded that the methods employed in meta-analyses of test performance have improved with the introduction of quality assessment checklists and the development of more sophisticated statistical methods.
AHRQ-funded; 290200710055I; HS013328.
Citation: Dahabreh IJ, Chung M, Kitsios GD .
Survey of the methods and reporting practices in published meta-analyses of test performance: 1987 to 2009.
Res Synth Methods 2013 Sep;4(3):242-55. doi: 10.1002/jrsm.1083.
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Keywords: Comparative Effectiveness, Diagnostic Safety and Quality, Research Methodologies
Schneeweiss S, Seeger JD, Jackson JW
AHRQ Author: Smith SR
Methods for comparative effectiveness research/patient-centered outcomes research: from efficacy to effectiveness.
This article provides an overview of papers in this supplement resulting from a June 2012 AHRQ-sponsored symposium on research methods for CER and patient-centered outcomes research.
AHRQ-authored.
Citation: Schneeweiss S, Seeger JD, Jackson JW .
Methods for comparative effectiveness research/patient-centered outcomes research: from efficacy to effectiveness.
J Clin Epidemiol 2013 Aug;66(8 Suppl):S1-4. doi: 10.1016/j.jclinepi.2013.05.012.
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Keywords: Comparative Effectiveness, Evidence-Based Practice, Patient-Centered Healthcare, Patient-Centered Outcomes Research, Research Methodologies
Boland MR, Miotto R, Gao J
Feasibility of feature-based indexing, clustering, and search of clinical trials. A case study of breast cancer trials from ClinicalTrials.gov.
Searching through a large collection of clinical trials using existing technology is a daunting task. This study extracted 1,437 eligibility features from 80 stage III breast cancer clinical trials and found that it is feasible to develop feature-based indexing and clustering methods for clinical trials to identify trials with similar target populations and to improve trial search efficiency.
AHRQ-funded; HS019853.
Citation: Boland MR, Miotto R, Gao J .
Feasibility of feature-based indexing, clustering, and search of clinical trials. A case study of breast cancer trials from ClinicalTrials.gov.
Methods Inf Med. 2013;52(5):382-94. doi: 10.3414/ME12-01-0092..
Keywords: Cancer: Breast Cancer, Cancer, Research Methodologies
Fleurence R, Selby JV, Odom-Walker K
AHRQ Author: Slutsky JR
How the Patient-Centered Outcomes Research Institute is engaging patients and others in shaping its research agenda.
This article describes PCORI's approach to generating topics for research and how it is being used in selection of research that PCORI will fund. It further describes challenges facing this approach, including a lack of common language and training on the part of patients and resistance on the part of researchers to questions that are not researcher generated.
AHRQ-authored.
Citation: Fleurence R, Selby JV, Odom-Walker K .
How the Patient-Centered Outcomes Research Institute is engaging patients and others in shaping its research agenda.
Health Aff 2013 Feb;32(2):393-400. doi: 10.1377/hlthaff.2012.1176.
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Keywords: Health Services Research (HSR), Patient and Family Engagement, Patient-Centered Outcomes Research, Research Methodologies