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AHRQ Research Studies
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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
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1 to 5 of 5 Research Studies DisplayedGarcia I, Chiodo V, Ma Y
Evidence of altered matrix composition in iliac crest biopsies from patients with idiopathic juvenile osteoporosis.
The goal of this study is to describe idiopathic juvenile osteoporosis (IJO)bone composition. It concluded that IJO bone, similar to post-menopausal osteoporosis (PMO) bone, had elevated collagen maturity relative to its age-matched controls. This emphasizes the importance of the collagen matrix for bone health. IJO bone differed from PMO bone as IJO bone contains more recently formed mineral than age-matched controls.
AHRQ-funded; HS021734.
Citation: Garcia I, Chiodo V, Ma Y .
Evidence of altered matrix composition in iliac crest biopsies from patients with idiopathic juvenile osteoporosis.
Connect Tissue Res 2016;57(1):28-37. doi: 10.3109/03008207.2015.1088531.
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Keywords: Osteoporosis, Children/Adolescents, Children/Adolescents
Cram P, Wolinsky FD, Lou Y
Patient-activation and guideline-concordant pharmacological treatment after bone density testing: the PAADRN randomized controlled trial.
In a clinical trial of 7749 patients, the researchers tested whether usual care augmented by a tailored patient-activation DXA result letter accompanied by an educational brochure would improve guideline-concordant pharmacological treatment compared to usual care only. They found that treatment rates did not improve.
AHRQ-funded; HS023009.
Citation: Cram P, Wolinsky FD, Lou Y .
Patient-activation and guideline-concordant pharmacological treatment after bone density testing: the PAADRN randomized controlled trial.
Osteoporos Int 2016 Dec;27(12):3513-24. doi: 10.1007/s00198-016-3681-9.
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Keywords: Education: Patient and Caregiver, Guidelines, Medication, Osteoporosis, Patient and Family Engagement
Edmonds SW, Cram P, Lou Y
Effects of a DXA result letter on satisfaction, quality of life, and osteoporosis knowledge: a randomized controlled trial.
This study tested whether a tailored dual energy x-ray absorptiometry (DXA) test result letter and an accompanying educational bone-health brochure affected patient satisfaction, quality of life (QOL), or osteoporosis (OP) knowledge. It found that a tailored DXA result letter and bone-health educational brochure sent to patients improved patient satisfaction with bone-related health care. There were no differences between the intervention and usual care groups in QOL or OP knowledge.
AHRQ-funded; HS023009.
Citation: Edmonds SW, Cram P, Lou Y .
Effects of a DXA result letter on satisfaction, quality of life, and osteoporosis knowledge: a randomized controlled trial.
BMC Musculoskelet Disord 2016 Aug 26;17(1):369. doi: 10.1186/s12891-016-1227-0.
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Keywords: Education: Patient and Caregiver, Osteoporosis, Patient Experience, Quality of Life
Fenton JJ, Robbins JA, Amarnath AL
Osteoporosis overtreatment in a regional health care system.
The researchers estimated the frequency of osteoporosis overtreatment in a regional health care system where DXA reports routinely include T scores for anatomic sites (e.g., lateral lumbar spine) that the International Society for Clinical Densitometry does not recommend for osteoporosis diagnosis. They found that two-thirds of new osteoporosis drug prescriptions were potentially inappropriate.
AHRQ-funded; HS022236.
Citation: Fenton JJ, Robbins JA, Amarnath AL .
Osteoporosis overtreatment in a regional health care system.
JAMA Intern Med 2016 Mar;176(3):391-3. doi: 10.1001/jamainternmed.2015.6020.
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Keywords: Decision Making, Diagnostic Safety and Quality, Medication, Osteoporosis
LaFleur J, Rillamas-Sun E, Colon-Emeric CS
Fracture rates and bone density among postmenopausal veteran and non-veteran women from the Women's Health Initiative.
The authors compared fracture rates and bone mineral density for veterans and non-veterans using Women's Health Initiative data. They found that veterans had higher 10-year probabilities for any major fracture and hip fracture compared with non-veterans, but that risk of fracture at other anatomic sites did not differ by veteran status. They concluded that female veterans had an increased hip fracture rate not explained by differences in well-recognized fracture risk factors.
AHRQ-funded; HS018582.
Citation: LaFleur J, Rillamas-Sun E, Colon-Emeric CS .
Fracture rates and bone density among postmenopausal veteran and non-veteran women from the Women's Health Initiative.
Gerontologist 2016 Feb;56 Suppl 1:S78-90. doi: 10.1093/geront/gnv677.
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Keywords: Elderly, Injuries and Wounds, Osteoporosis, Women