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AHRQ Research Studies Date
Topics
- Adverse Drug Events (ADE) (7)
- Adverse Events (2)
- Behavioral Health (1)
- Children/Adolescents (2)
- Communication (1)
- Community-Based Practice (2)
- Comparative Effectiveness (1)
- Dementia (1)
- Depression (1)
- Elderly (3)
- Emergency Medical Services (EMS) (1)
- Falls (1)
- Injuries and Wounds (1)
- Medication (10)
- (-) Medication: Safety (12)
- Neurological Disorders (2)
- Newborns/Infants (1)
- Nursing Homes (2)
- Opioids (1)
- Patient Adherence/Compliance (2)
- Patient Safety (5)
- Practice-Based Research Network (PBRN) (2)
- Practice Patterns (1)
- Provider: Pharmacist (2)
- Stroke (1)
AHRQ Research Studies
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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
Results
1 to 12 of 12 Research Studies DisplayedAhuja V, Sohn MW, Birge JR
Geographic variation in rosiglitazone use surrounding FDA warnings in the Department of Veterans Affairs.
The purpose of this study was to document variation in the use of rosiglitazone and other glucose- lowering drugs across 21 Veterans Integrated Service Networks. It found that aggregate rosiglitazone use increased monotonically from 7.7 percent, in the quarter it was added to the VA formulary, to a peak of 15.3 percent in the quarter when the FDA issued the safety alert.
AHRQ-funded; HS018542.
Citation: Ahuja V, Sohn MW, Birge JR .
Geographic variation in rosiglitazone use surrounding FDA warnings in the Department of Veterans Affairs.
J Manag Care Spec Pharm 2015 Dec;21(12):1214-34. doi: 10.18553/jmcp.2015.21.12.1214.
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Keywords: Adverse Drug Events (ADE), Medication: Safety, Medication, Practice Patterns
Patel P, Hemmeger H, Kozak MA
Community pharmacist participation in a practice-based research network: a report from the Medication Safety Research Network of Indiana (Rx-SafeNet).
The researchers described the experiences and opinions of pharmacists serving as site coordinators for the Medication Safety Research Network of Indiana (Rx-SafeNet). In general, Rx-SafeNet site coordinators appeared to experience increased confidence in research engagement after joining the network. While respondents identified a number of benefits associated with network participation, concerns about potential time constraints remained a key barrier to participation.
AHRQ-funded; HS022119.
Citation: Patel P, Hemmeger H, Kozak MA .
Community pharmacist participation in a practice-based research network: a report from the Medication Safety Research Network of Indiana (Rx-SafeNet).
J Am Pharm Assoc (2003) 2015 Nov-Dec;55(6):649-55. doi: 10.1331/JAPhA.2015.14244.
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Keywords: Community-Based Practice, Medication: Safety, Practice-Based Research Network (PBRN), Provider: Pharmacist
Gagne JJ, Kesselheim AS, Choudhry NK
Comparative effectiveness of generic versus brand-name antiepileptic medications.
The objective of this study was to compare treatment persistence and rates of seizure-related events in patients who initiate antiepileptic drug (AED) therapy with a generic versus a brand-name product. It concluded that patients who initiated generic AEDs had fewer adverse seizure-related clinical outcomes and longer continuous treatment periods before experiencing a gap than those who initiated brand-name versions.
AHRQ-funded; HS018465.
Citation: Gagne JJ, Kesselheim AS, Choudhry NK .
Comparative effectiveness of generic versus brand-name antiepileptic medications.
Epilepsy Behav 2015 Nov;52(Pt A):14-8. doi: 10.1016/j.yebeh.2015.08.014.
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Keywords: Adverse Drug Events (ADE), Adverse Events, Comparative Effectiveness, Medication, Medication: Safety, Neurological Disorders, Patient Safety
Culley CM, Perera S, Marcum ZA
Using a clinical surveillance system to detect drug-associated hypoglycemia in nursing home residents.
The authors determined whether a clinical surveillance system could be used to detect drug-associated hypoglycemia events and determine their incidence in nursing home (NH) residents. Their evaluation found a high incidence of drug-associated hypoglycemia in a general NH population.
AHRQ-funded; HS018721.
Citation: Culley CM, Perera S, Marcum ZA .
Using a clinical surveillance system to detect drug-associated hypoglycemia in nursing home residents.
J Am Geriatr Soc 2015 Oct;63(10):2125-9. doi: 10.1111/jgs.13648.
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Keywords: Adverse Drug Events (ADE), Elderly, Medication: Safety, Medication, Nursing Homes
Kao DP, Haigney MC, Mehler PS
Arrhythmia associated with buprenorphine and methadone reported to the Food and Drug Administration.
The researchers assessed the relative frequency of reporting of adverse events involving ventricular arrhythmia, cardiac arrest, corrected QT interval prolongation or torsade de pointes to the US Food and Drug Administration between buprenorphine and methadone. They found that in spontaneously reported adverse events between 1969 and June 2011 originating in 196 countries, methadone is associated with disproportionate reporting of cardiac arrhythmias, whereas buprenorphine is not.
AHRQ-funded; HS021138.
Citation: Kao DP, Haigney MC, Mehler PS .
Arrhythmia associated with buprenorphine and methadone reported to the Food and Drug Administration.
Addiction 2015 Sep;110(9):1468-75. doi: 10.1111/add.13013.
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Keywords: Adverse Drug Events (ADE), Medication: Safety, Medication, Patient Safety
Basco WT, Ebeling M, Garner SS
Opioid prescribing and potential overdose errors among children 0 to 36 months old.
This study estimated the frequency of potential overdoses among outpatient opioid-containing prescriptions. It found that, overall, 2.7 percent of the prescriptions contained potential overdose quantities, and the average excess amount dispensed was 48% above expected. Younger ages were associated with higher frequencies of potential overdose.
AHRQ-funded; HS015679.
Citation: Basco WT, Ebeling M, Garner SS .
Opioid prescribing and potential overdose errors among children 0 to 36 months old.
Clin Pediatr 2015 Jul;54(8):738-44. doi: 10.1177/0009922815586050..
Keywords: Adverse Drug Events (ADE), Children/Adolescents, Newborns/Infants, Medication, Medication: Safety, Newborns/Infants, Opioids, Patient Safety
Samples H, Mojtabai R
Antidepressant self-discontinuation: results from the collaborative psychiatric epidemiology surveys.
The authors examined the extent and correlates of self-discontinuation of antidepressant medications without physician advice using the Collaborative Psychiatric Epidemiology Surveys. They concluded that physicians prescribing antidepressants need to communicate clearly about the expected benefits of treatment, the minimum duration of use required to experience benefits, and the potential side effects of these medications, particularly to younger patients, those with anxiety disorders, and patients treated in general medical settings, all of whom have increased odds of self-discontinuation.
AHRQ-funded; HS000029.
Citation: Samples H, Mojtabai R .
Antidepressant self-discontinuation: results from the collaborative psychiatric epidemiology surveys.
Psychiatr Serv 2015 May;66(5):455-62. doi: 10.1176/appi.ps.201400021.
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Keywords: Medication, Depression, Medication: Safety, Behavioral Health, Patient Adherence/Compliance
Marcum ZA, Gurwitz JH, Colon-Emeric C
Pills and ills: methodological problems in pharmacological research.
This letter summarizes critical points from a methodology workshop, Pills and Ills: Methodologic Issues in Pharmacologic Research, presented at the 2013 American Geriatrics Society Annual Scientific Meeting. It focuses on two of the most important medication errors in older adults: potentially inappropriate medication use and medication nonadherence.
AHRQ-funded; HS020831.
Citation: Marcum ZA, Gurwitz JH, Colon-Emeric C .
Pills and ills: methodological problems in pharmacological research.
J Am Geriatr Soc 2015 Apr;63(4):829-30. doi: 10.1111/jgs.13371..
Keywords: Medication, Medication: Safety, Elderly, Patient Adherence/Compliance
Radecki RP, Azam A, Doshi PB
Iodinated contrast prior to thrombolysis was not associated with worse intracranial hemorrhage.
The investigators' objective was to assess relative incidence of clinical adverse effects between patients receiving, and not receiving, iodinated contrast prior to thrombolysis. They found that no consistent harms were observed in association with intravenous iodinated contrast prior to recombinant tissue-type plasminogen activator administration, concluding that it is reasonable to continue computed tomographic angiography prior to thrombolysis as clinically indicated.
AHRQ-funded; HS017586.
Citation: Radecki RP, Azam A, Doshi PB .
Iodinated contrast prior to thrombolysis was not associated with worse intracranial hemorrhage.
Acad Emerg Med 2015 Mar;22(3):259-63. doi: 10.1111/acem.12603.
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Keywords: Adverse Drug Events (ADE), Emergency Medical Services (EMS), Medication, Medication: Safety, Stroke
Aspinall SL, Zhao X, Semia TP
Epidemiology of drug-disease interactions in older veteran nursing home residents.
The objective of this study was to assess the prevalence of and factors associated with potentially inappropriate drug– disease combinations according to the AGS 2012 Beers criteria that are clinically important in elderly adults residing in Veterans Affairs Community Living Centers. It found that drug-disease interactions were common in older residents with dementia or cognitive impairment or a history of falls or hip fracture.
AHRQ-funded; HS018721.
Citation: Aspinall SL, Zhao X, Semia TP .
Epidemiology of drug-disease interactions in older veteran nursing home residents.
J Am Geriatr Soc 2015 Jan;63(1):77-84. doi: 10.1111/jgs.13197..
Keywords: Adverse Drug Events (ADE), Adverse Events, Dementia, Elderly, Falls, Injuries and Wounds, Medication, Medication: Safety, Neurological Disorders, Nursing Homes, Patient Safety
Benjamin JM, Cox ED, Trapskin PJ
Family-initiated dialogue about medications during family-centered rounds.
The researchers sought to further understand the potential for family-centered rounds (FCRs) to foster pediatric medication safety. To that end, their study describes and quantifies medication-related topics raised by families during FCR and how this dialogue affects the children’s treatment plans. The families raised topics that altered treatment and were important for medication safety, adherence, and satisfaction.
AHRQ-funded; HS018680
Citation: Benjamin JM, Cox ED, Trapskin PJ .
Family-initiated dialogue about medications during family-centered rounds.
Pediatrics. 2015 Jan;135(1):94-101. doi: 10.1542/peds.2013-3885..
Keywords: Children/Adolescents, Communication, Medication: Safety, Patient Safety
Kozak MA, Gernant SA, Hemmeger HM
Lessons learned in the growth and maturation stages of a community pharmacy practice-based research network: experiences of the Medication Safety Research Network of Indiana (Rx-SafeNet).
In 2012, the authors reported on their early experiences developing the Medication Safety Research Network of Indiana (Rx-SafeNet) after establishing the Network in 2010. In this article, they report on lessons learned over the past 3 years.
AHRQ-funded; HS022119.
Citation: Kozak MA, Gernant SA, Hemmeger HM .
Lessons learned in the growth and maturation stages of a community pharmacy practice-based research network: experiences of the Medication Safety Research Network of Indiana (Rx-SafeNet).
Innov Pharm 2015;6(2).
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Keywords: Community-Based Practice, Medication: Safety, Medication, Provider: Pharmacist, Practice-Based Research Network (PBRN)