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AHRQ Research Studies
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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
Results
1 to 3 of 3 Research Studies DisplayedLinden S, Bussing R, Kubilis P
Risk of suicidal events with atomoxetine compared to stimulant treatment: a cohort study.
The researchers analyzed whether the observed increased risk of suicidal ideation in clinical trials translates into an increased risk of suicidal events in pediatric patients treated with atomoxetine compared with stimulants in 26 Medicaid programs. They found that first- and second-line treatment of youths age 5 to 18 with atomoxetine compared with stimulants was not significantly associated with an increased risk of suicidal events.
AHRQ-funded; HS018506; HS016097.
Citation: Linden S, Bussing R, Kubilis P .
Risk of suicidal events with atomoxetine compared to stimulant treatment: a cohort study.
Pediatrics 2016 May;137(5):pii: e20153199. doi: 10.1542/peds.2015-3199.
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Keywords: Adverse Drug Events (ADE), Medication, Children/Adolescents, Comparative Effectiveness, Patient-Centered Outcomes Research
Nierenberg AA, McElroy SL, Friedman ES
Bipolar CHOICE (Clinical Health Outcomes Initiative in Comparative Effectiveness): a pragmatic 6-month trial of lithium versus quetiapine for bipolar disorder.
The purpose of this trial was to compare lithium and second-generation antipsychotics. The investigators found that outcomes with lithium + APT and quetiapine + APT were not significantly different across 6 months of treatment for bipolar disorder.
AHRQ-funded; HS019371.
Citation: Nierenberg AA, McElroy SL, Friedman ES .
Bipolar CHOICE (Clinical Health Outcomes Initiative in Comparative Effectiveness): a pragmatic 6-month trial of lithium versus quetiapine for bipolar disorder.
J Clin Psychiatry 2016 Jan;77(1):90-9. doi: 10.4088/JCP.14m09349.
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Keywords: Adverse Drug Events (ADE), Comparative Effectiveness, Medication, Behavioral Health, Patient-Centered Outcomes Research
Brookhart MA, Freburger JK, Ellis AR
Comparative short-term safety of sodium ferric gluconate versus iron sucrose in hemodialysis patients.
Despite different pharmacologic properties, little is known about the comparative safety of sodium ferric gluconate versus iron sucrose in hemodialysis patients. This study found that, overall, the 2 iron formulations studied exhibited similar safety profiles; however, ferric gluconate was associated with a slightly decreased risk for infection-related outcomes compared to iron sucrose among patients with a hemodialysis catheter.
AHRQ-funded; 290200500401.
Citation: Brookhart MA, Freburger JK, Ellis AR .
Comparative short-term safety of sodium ferric gluconate versus iron sucrose in hemodialysis patients.
Am J Kidney Dis 2016 Jan;67(1):119-27. doi: 10.1053/j.ajkd.2015.07.026.
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Keywords: Comparative Effectiveness, Kidney Disease and Health, Medication: Safety, Outcomes, Adverse Drug Events (ADE)