National Healthcare Quality and Disparities Report
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- Access to Care (1)
- Adverse Drug Events (ADE) (2)
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- Ambulatory Care and Surgery (1)
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- Antimicrobial Stewardship (1)
- Arthritis (1)
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- Blood Thinners (1)
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- Comparative Effectiveness (2)
- Critical Care (1)
- Decision Making (2)
- Diabetes (1)
- Diagnostic Safety and Quality (2)
- (-) Digestive Disease and Health (40)
- Disparities (2)
- Education: Patient and Caregiver (1)
- Elderly (5)
- Emergency Department (1)
- Emergency Medical Services (EMS) (1)
- Evidence-Based Practice (2)
- Genetics (4)
- Healthcare Cost and Utilization Project (HCUP) (2)
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- Mortality (1)
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- Patient and Family Engagement (2)
- Patient Experience (1)
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- Practice Patterns (1)
- Prevention (2)
- Provider (1)
- Provider: Physician (1)
- Public Health (1)
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- Quality of Care (2)
- Racial and Ethnic Minorities (4)
- Respiratory Conditions (1)
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- Screening (2)
- Sepsis (1)
- Skin Conditions (1)
- Surgery (8)
- Telehealth (1)
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AHRQ Research Studies
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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
Results
1 to 25 of 40 Research Studies DisplayedDulai PS, Singh S, Casteele NV
Development and validation of clinical scoring tool to predict outcomes of treatment with vedolizumab in patients with ulcerative colitis.
AHRQ-funded; HS021747.
Citation: Dulai PS, Singh S, Casteele NV .
Development and validation of clinical scoring tool to predict outcomes of treatment with vedolizumab in patients with ulcerative colitis.
Clin Gastroenterol Hepatol 2020 Dec;18(13):2952-61.e8. doi: 10.1016/j.cgh.2020.02.010..
Keywords: Clinical Decision Support (CDS), Digestive Disease and Health, Outcomes
Shah SC, Canakis A, Peek RM
Endoscopy for gastric cancer screening is cost effective for Asian Americans in the United States.
Endoscopic screening for gastric cancer is routine in some countries with high incidence and is associated with reduced gastric cancer-related mortality. Immigrants from countries of high incidence to low incidence of gastric cancer retain their elevated risk, but no screening recommendations have been made for these groups in the United States. In this study the investigators aimed to determine the cost effectiveness of different endoscopic screening strategies for noncardia gastric cancer, compared with no screening, among Chinese, Filipino, Southeast Asian, Vietnamese, Korean, and Japanese Americans.
AHRQ-funded; HS026395.
Citation: Shah SC, Canakis A, Peek RM .
Endoscopy for gastric cancer screening is cost effective for Asian Americans in the United States.
Clin Gastroenterol Hepatol 2020 Dec;18(13):3026-39. doi: 10.1016/j.cgh.2020.07.031..
Keywords: Cancer, Digestive Disease and Health, Screening, Racial and Ethnic Minorities, Healthcare Costs
Bartsch SM, O'Shea KJ, Lee BY
The clinical and economic burden of norovirus gastroenteritis in the United States.
This study’s objective was to quantify the clinical and economic burden of norovirus gastroenteritis outbreaks in the US. A computational simulation model was developed. The total cost was $10.6 billion annually based on current incidence estimate. Specific cases constituted greater than 90% and productivity losses represented 89% of the loss due to missed school or workdays. More than half the economic burden is in adults 45 years or older and occurs in winter months; and greater than 90% of outbreak costs are due to person-to-person transmission.
AHRQ-funded; HS023317.
Citation: Bartsch SM, O'Shea KJ, Lee BY .
The clinical and economic burden of norovirus gastroenteritis in the United States.
J Infect Dis 2020 Dec 1;222(11):1910-19. doi: 10.1093/infdis/jiaa292..
Keywords: Digestive Disease and Health, Healthcare Costs
Daniel VT, Francalancia S, Amir NS
Upper gastrointestinal perforations: a possible danger of antibiotic overuse.
Investigators conducted a retrospective case-control study to examine the relationship between antibiotic exposure and upper gastrointestinal (UGI) perforations in a national sample. A 5% random sample of Medicare were queried to identify patients at least 65 years old who were hospitalized with stomach or small intestine UGI perforations using International Classification of Diseases diagnosis codes; Cases with UGI perforations were matched with 4 controls based on age and sex. The investigators concluded that recent outpatient antibiotic use, in particular in the preceding 30 days, is associated with UGI perforation among Medicare beneficiaries. They recommended minimizing exposure to antibiotics in the outpatient setting.
AHRQ-funded; HS022694.
Citation: Daniel VT, Francalancia S, Amir NS .
Upper gastrointestinal perforations: a possible danger of antibiotic overuse.
J Gastrointest Surg 2020 Dec;24(12):2730-36. doi: 10.1007/s11605-019-04473-w..
Keywords: Digestive Disease and Health, Antimicrobial Stewardship, Antibiotics, Medication, Adverse Drug Events (ADE), Adverse Events
Orloff JN, Touhamy SH, Truong W
Trial of restarting and tolerating metformin (TreatMet).
This randomized, double-blind, placebo-controlled, n-of-1 crossover study assessed whether metformin's side effects are reproducible in patients with a history of metformin intolerance. Participants completed up to four cycles of 2 weeks of metformin exposure and 2 weeks of placebo exposure. Participants completed surveys based on the Gastrointestinal Symptom Rating Scale and the Treatment Satisfaction Questionnaire for Medication.
AHRQ-funded; HS023898.
Citation: Orloff JN, Touhamy SH, Truong W .
Trial of restarting and tolerating metformin (TreatMet).
Diabetes Obes Metab 2020 Nov;22(11):2189-92. doi: 10.1111/dom.14137..
Keywords: Medication, Digestive Disease and Health, Diabetes, Chronic Conditions
Shah SC, McKinley M, Gupta S
Population-based analysis of differences in gastric cancer incidence among races and ethnicities in individuals age 50 years and older.
There are racial and ethnic differences in the incidence of gastric adenocarcinoma worldwide and in the US. Based on a decision analysis, screening for noncardia gastric adenocarcinoma might be cost-effective for non-White individuals 50 years or older. In this study, the investigators aimed to estimate the differences in gastric adenocarcinoma incidence in specific anatomic sites among races and ethnicities in individuals 50 years or older.
AHRQ-funded; HS026395.
Citation: Shah SC, McKinley M, Gupta S .
Population-based analysis of differences in gastric cancer incidence among races and ethnicities in individuals age 50 years and older.
Gastroenterology 2020 Nov;159(5):1705-14.e2. doi: 10.1053/j.gastro.2020.07.049..
Keywords: Elderly, Cancer, Digestive Disease and Health, Racial and Ethnic Minorities, Disparities
Leeds IL, Jones C, DiBrito SR
Delay in emergency hernia surgery is associated with worse outcomes.
The purpose of this study was to determine if the variation in timing of urgent surgery impacts surgical outcomes. The National Surgical Quality Improvement Program (NSQIP) database was searched for emergent surgeries in 2011-2016 for abdominal hernia resulting in obstruction or gangrene by primary post-op diagnosis. Findings showed that delayed surgery was associated with increased rates of major complications, longer operative times, longer postoperative lengths of stay, increased re-operations, increased readmissions, and increased 30-day mortality. Next-day surgery and surgery delayed more than one day were associated with increased odds of a major complication.
AHRQ-funded; HS024547.
Citation: Leeds IL, Jones C, DiBrito SR .
Delay in emergency hernia surgery is associated with worse outcomes.
Surg Endosc 2020 Oct;34(10):4562-73. doi: 10.1007/s00464-019-07245-4..
Keywords: Surgery, Quality Improvement, Quality of Care, Critical Care, Access to Care, Digestive Disease and Health, Outcomes
Dos Santos Marques IC, Theiss LM, Baker SJ
Low health literacy exists in the inflammatory bowel disease (IBD) population and is disproportionately prevalent in older African Americans.
This study assessed the prevalence of low health literacy rates among adult patients with inflammatory bowel disease (IBD) in a diverse population and identified risk factors for low health literacy. IBD patients at a single institution from November 2017 to May 2018 were assessed for health literacy using the Newest Vital Sign (NWS). Secondary outcomes were length-of-stay (LOS) and 30-day readmissions after surgery. There were 175 patients surveyed who were 59% female, 23% African Americans, 91% with Crohn’s disease, and mean age was 46. Overall the low health literacy rate was 24%, with African Americans having a higher prevalence (47.5%) versus 17.0% for white IBD patients. Low health literacy was associated with older age and African American race. There were no significant differences between LOS and readmissions rates by health literacy levels.
AHRQ-funded; HS023009.
Citation: Dos Santos Marques IC, Theiss LM, Baker SJ .
Low health literacy exists in the inflammatory bowel disease (IBD) population and is disproportionately prevalent in older African Americans.
Crohns Colitis 360 2020 Oct;2(4). doi: 10.1093/crocol/otaa076..
Keywords: Elderly, Health Literacy, Digestive Disease and Health, Racial and Ethnic Minorities, Chronic Conditions
Sherwin LB, Ross D, Matteson-Kome M
Patient perspectives on short-course pharmacotherapy: barriers and facilitators to medication adherence.
This study examined patient perspectives on adherence and factors that influence adherence to short-course pharmacotherapy in diarrhea-predominant irritable bowel syndrome. The investigators concluded that the resulting patient perspectives highlighted a diverse set of factors that influence short-course adherence and the need for tailored interventions that address these various factors resulting in enhanced patient outcomes
AHRQ-funded; HS022140.
Citation: Sherwin LB, Ross D, Matteson-Kome M .
Patient perspectives on short-course pharmacotherapy: barriers and facilitators to medication adherence.
J Patient Exp 2020 Oct;7(5):726-33. doi: 10.1177/2374373519882230..
Keywords: Patient Adherence/Compliance, Medication, Digestive Disease and Health
Shah SC, Itzkowitz SH
Reappraising risk factors for inflammatory bowel disease-associated neoplasia: implications for colonoscopic surveillance in IBD.
One of the most feared complications of inflammatory bowel disease [IBD]-associated colitis is colorectal cancer. An opportunity for early detection is being missed in a group that is overlooked as high-risk, as a substantial proportion of colorectal cancers are being diagnosed in individuals with colonic IBD who have disease duration shorter than when guidelines recommend surveillance initiation. In this study, the investigators discuss a viewpoint that supports a paradigm shift that will ideally result in a more effective and higher-value colorectal cancer prevention approach in IBD.
AHRQ-funded; HS026395.
Citation: Shah SC, Itzkowitz SH .
Reappraising risk factors for inflammatory bowel disease-associated neoplasia: implications for colonoscopic surveillance in IBD.
J Crohns Colitis 2020 Sep 7;14(8):1172-77. doi: 10.1093/ecco-jcc/jjaa040..
Keywords: Digestive Disease and Health, Risk, Cancer: Colorectal Cancer, Cancer, Colonoscopy, Prevention, Diagnostic Safety and Quality, Screening
Vitous CA, Jafri SM, Seven C
Exploration of surgeon motivations in management of abdominal wall hernias: a qualitative study.
Although evidence-based guidelines designed to minimize health care variation and promote effective care are widely accepted, creating guidelines alone does not often lead to the desired practice change. Such knowledge-to-practice gaps are well-recognized in the management of patients with abdominal wall hernia. The purpose of this study was to evaluate the systematic application of the Theoretical Domains Framework (TDF) to explore motivations and behaviors associated with surgical decision-making in abdominal wall hernia practice to help inform the future design of theory-based interventions for desired practice and behavior change.
AHRQ-funded; HS025778.
Citation: Vitous CA, Jafri SM, Seven C .
Exploration of surgeon motivations in management of abdominal wall hernias: a qualitative study.
JAMA Netw Open 2020 Sep;3(9):e2015916. doi: 10.1001/jamanetworkopen.2020.15916..
Keywords: Surgery, Digestive Disease and Health, Provider: Physician, Provider
Steele MK, Wikswo ME, Hall AJ
Characterizing norovirus transmission from outbreak data, United States.
Norovirus is the leading cause of acute gastroenteritis outbreaks in the United States. In this study, the investigators estimated the basic (R(0)) and effective (R(e)) reproduction numbers for 7,094 norovirus outbreaks reported to the National Outbreak Reporting System (NORS) during 2009-2017 and used regression models to assess whether transmission varied by outbreak setting.
AHRQ-funded; HS025987.
Citation: Steele MK, Wikswo ME, Hall AJ .
Characterizing norovirus transmission from outbreak data, United States.
Emerg Infect Dis 2020 Aug;26(8):1818-25. doi: 10.3201/eid2608.191537..
Keywords: Infectious Diseases, Public Health, Digestive Disease and Health
Sherwin LB, Deroche CB, Krisanabud P
Adherence to short-course pharmacotherapy in adults with irritable bowel syndrome.
Irritable Bowel Syndrome (IBS), characterized by abdominal pain and bowel dysfunction, treatment focuses on alleviating symptoms. Adherence is crucial for pharmacologic management success. This study examined 73 adult's objective adherence to rifaximin using the taxonomy for adherence. Demographic, quality of life (QOL), psychological distress, perceived stress, adverse childhood experiences (ACE), pain, and adherence data were collected.
AHRQ-funded; HS022140.
Citation: Sherwin LB, Deroche CB, Krisanabud P .
Adherence to short-course pharmacotherapy in adults with irritable bowel syndrome.
AHRQ-funded; HS022140..
Keywords: Digestive Disease and Health, Chronic Conditions, Medication, Patient Adherence/Compliance
Mahmoud R, Shah SC, Torres J
Association between indefinite dysplasia and advanced neoplasia in patients with inflammatory bowel diseases undergoing surveillance.
Little is known about the clinical significance of indefinite dysplasia (IND) in patients with inflammatory bowel diseases (IBD) undergoing colonoscopic surveillance for colorectal neoplasia. The investigators conducted a retrospective cohort analysis from 2001 through 2017. They concluded that patients with IBD undergoing colorectal neoplasia surveillance with consistent histopathologic grading of dysplasia, IND was independently associated with a significant increase in risk of advanced colorectal neoplasia.
AHRQ-funded; HS026395.
Citation: Mahmoud R, Shah SC, Torres J .
Association between indefinite dysplasia and advanced neoplasia in patients with inflammatory bowel diseases undergoing surveillance.
Clin Gastroenterol Hepatol 2020 Jun;18(7):1518-27.e3. doi: 10.1016/j.cgh.2019.08.032..
Keywords: Cancer: Colorectal Cancer, Cancer, Digestive Disease and Health
Shah SC, Dai Zhu, X
Associations between calcium and magnesium intake and the risk of incident gastric cancer: a prospective cohort analysis of the National Institutes of Health-American Association of Retired Persons (NIH-AARP) Diet and Health Study.
Gastric cancer remains a leading cause of cancer-related mortality. Identifying dietary and other modifiable disease determinants has important implications for risk attenuation in susceptible individuals. The primary aim of the investigators was to estimate the association between dietary and supplemental intakes of calcium and magnesium and the risk of incident gastric cancer. They conducted a prospective cohort analysis of the National Institutes of Health-American Association of Retired Persons Diet and Health Study.
AHRQ-funded; HS026395.
Citation: Shah SC, Dai Zhu, X .
Associations between calcium and magnesium intake and the risk of incident gastric cancer: a prospective cohort analysis of the National Institutes of Health-American Association of Retired Persons (NIH-AARP) Diet and Health Study.
Int J Cancer 2020 Jun 1;146(11):2999-3010. doi: 10.1002/ijc.32659..
Keywords: Cancer, Digestive Disease and Health, Risk, Prevention, Nutrition, Patient-Centered Outcomes Research, Evidence-Based Practice
Adelman MW, Woodworth MH, Langelier C
The gut microbiome's role in the development, maintenance, and outcomes of sepsis.
This paper examines the gut microbiome’s role in the development, maintenance and outcomes of sepsis. The authors focus on the key three areas of the interaction between the gut microbiome and sepsis and how once sepsis is established the gut microbiome worsens and increases susceptibility to end-organ dysfunction. They outline a potential research agenda for further investigating the interaction between the gut microbiome and sepsis.
AHRQ-funded; HS025240.
Citation: Adelman MW, Woodworth MH, Langelier C .
The gut microbiome's role in the development, maintenance, and outcomes of sepsis.
Crit Care 2020 Jun 1;24(1):278. doi: 10.1186/s13054-020-02989-1..
Keywords: Digestive Disease and Health, Sepsis
Yuce TK, Ellis RJ, Merkow RP
Post-operative complications and readmissions following outpatient elective Nissen fundoplication.
Traditionally, laparoscopic Nissen fundoplication (LNF) has been considered an inpatient procedure. Advances in surgical and anesthetic techniques have led to a shift towards outpatient LNF procedures. However, differences in surgical outcomes between outpatient and inpatient LNF are poorly understood. The objectives of this study were (1) to describe the frequency of outpatient LNF in a national cohort and (2) to identify any differences in complications or readmission rates between outpatient and inpatient LNF.
AHRQ-funded; HS024516.
Citation: Yuce TK, Ellis RJ, Merkow RP .
Post-operative complications and readmissions following outpatient elective Nissen fundoplication.
Surg Endosc 2020 May;34(5):2143-48. doi: 10.1007/s00464-019-07020-5..
Keywords: Surgery, Hospital Readmissions, Adverse Events, Ambulatory Care and Surgery, Digestive Disease and Health, Patient Safety
Shah SC, Boffetta P, Johnson KC SC, Boffetta P, Johnson KC
Occupational exposures and odds of gastric cancer: a StoP project consortium pooled analysis.
Gastric cancer pathogenesis represents a complex interaction of host genetic determinants, microbial virulence factors and environmental exposures. The primary aim of this study was to determine the association between occupations/occupational exposures and odds of gastric cancer. Based on a large pooled analysis, the investigators identified several occupations and related exposures that were associated with elevated odds of gastric cancer.
AHRQ-funded; HS026395.
Citation: Shah SC, Boffetta P, Johnson KC SC, Boffetta P, Johnson KC .
Occupational exposures and odds of gastric cancer: a StoP project consortium pooled analysis.
Int J Epidemiol 2020 Apr 1;49(2):422-34. doi: 10.1093/ije/dyz263..
Keywords: Cancer, Risk, Digestive Disease and Health
Cushing AM, Bucholz E, Michelson KA
Trends in regionalization of emergency care for common pediatric conditions.
This study examined trends in regionalization of emergency care for common pediatric conditions. The authors sought to determine how the likelihood of definitive care has changed for 3 common conditions: asthma, croup, and gastroenteritis. They used the National Emergency Department Sample Database to study children from 2008 to 2016 who presented to emergency departments with those primary diagnoses, excluding critically ill patients. Researchers conducted analyses by stratification of annual emergency department pediatric volume categorized by quartiles. Referral rates increased for all conditions in all volume quartiles, with referral rates greatest in the lowest pediatric volume quartile.
AHRQ-funded; HS026503.
Citation: Cushing AM, Bucholz E, Michelson KA .
Trends in regionalization of emergency care for common pediatric conditions.
Pediatrics 2020 Apr;145(4). doi: 10.1542/peds.2019-2989..
Keywords: Healthcare Cost and Utilization Project (HCUP), Children/Adolescents, Emergency Department, Asthma, Respiratory Conditions, Digestive Disease and Health, Healthcare Delivery
Pruitt LCC, Skarda DE, Rollins MD
Hirschsprung-associated enterocolitis in children treated at US children's hospitals.
The incidence of and risk factors for Hirschsprung's-associated enterocolitis (HAEC) following pull-through have been limited to single institutions studies. In this retrospective cohort study, the investigators characterized the incidence of, risk factors for, and consequences of post-operative HAEC. The investigators concluded that HAEC following pull-through occurs in a large proportion of infants with HD and predicts reoperation. They suggest that multicenter studies are needed to develop prediction models and treatment protocols for HAEC.
AHRQ-funded; HS025776.
Citation: Pruitt LCC, Skarda DE, Rollins MD .
Hirschsprung-associated enterocolitis in children treated at US children's hospitals.
J Pediatr Surg 2020 Mar;55(3):535-40. doi: 10.1016/j.jpedsurg.2019.10.060.
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Keywords: Children/Adolescents, Digestive Disease and Health, Surgery, Adverse Events, Risk, Hospitals
Pabla BS, Shah SC, Corral JE
Increased incidence and mortality of gastric cancer in immigrant populations from high to low regions of incidence: a systematic review and meta-analysis.
Gastric cancer is the leading cause of infection-related cancer death and the third-leading cause of cancer death worldwide. The effect of immigration on gastric cancer risk is not well-defined but might be helpful for screening or surveillance endeavors. In this study, the authors performed a systematic review and meta-analysis to define the risk of gastric cancer in immigrants from high-incidence regions to low-incidence regions (including Western Europe, Australia, Brazil, Canada, Israel, and the United States).
AHRQ-funded; HS026395.
Citation: Pabla BS, Shah SC, Corral JE .
Increased incidence and mortality of gastric cancer in immigrant populations from high to low regions of incidence: a systematic review and meta-analysis.
Clin Gastroenterol Hepatol 2020 Feb;18(2):347-59.e5. doi: 10.1016/j.cgh.2019.05.032..
Keywords: Cancer, Digestive Disease and Health, Mortality
Abraham NS, Noseworthy PA, Inselman J
Risk of gastrointestinal bleeding increases with combinations of antithrombotic agents and patient age.
This study investigated whether age of patient and time frame increased the risk of gastrointestinal bleeding (GIB) in elderly patients being treated with anticoagulants, antiplatelets, or a combination of both therapies. This retrospective analysis used nationwide claims data from privately insured and Medicare Advantage enrollees who received anticoagulant and/or antiplatelet agents from October 1, 2010, through May 31, 2017. The final cohort included 311,211 patients who had a primary diagnosis of atrial fibrillation, ischemic heart disease, or venous thromboembolism. There was no significant different in the proportion of patients with GIB after anticoagulant or antiplatelet monotherapy, but combination therapy increased GIB risk. Advancing age was also associated with increasing 1-year probability of FIB, especially patients older than 75 years taking combination therapy.
AHRQ-funded; HS025402.
Citation: Abraham NS, Noseworthy PA, Inselman J .
Risk of gastrointestinal bleeding increases with combinations of antithrombotic agents and patient age.
Clin Gastroenterol Hepatol 2020 Feb;18(2):337-46.e19. doi: 10.1016/j.cgh.2019.05.017..
Keywords: Adverse Drug Events (ADE), Medication, Adverse Events, Medication: Safety, Elderly, Blood Thinners, Blood Clots, Digestive Disease and Health
Khorfan R, Schlick CJR, Yang AD
Utilization of minimally invasive surgery and its association with chemotherapy for locally advanced gastric cancer.
This study compared outcomes of patients with T3 or greater and/or N+ gastric carcinoma who had minimally invasive surgery (MIS) or traditional open surgery. Patients who received MIS had a greater likelihood of receiving postoperative chemotherapy. Patients from the National Cancer Database (21,872) from 2010 to 2015 were identified. The majority (72.2%) received open surgery although MIS rates went up during that time period. Predictors of MIS were Asian race, any insurance coverage and treatment at high-volume centers. Survival rates were higher for MIS patients although that could be explained by their increased likelihood of receiving adjuvant chemotherapy.
AHRQ-funded; HS026385.
Citation: Khorfan R, Schlick CJR, Yang AD .
Utilization of minimally invasive surgery and its association with chemotherapy for locally advanced gastric cancer.
J Gastrointest Surg 2020 Feb;24(2):243-52. doi: 10.1007/s11605-019-04410-x.
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Keywords: Surgery, Treatments, Cancer, Digestive Disease and Health, Healthcare Utilization, Patient-Centered Outcomes Research, Outcomes, Evidence-Based Practice
Bilgrami Z, Abutaleb A, Chudy-Onwugaje K
Effect of TELEmedicine for inflammatory bowel disease on patient activation and self-efficacy.
This study examined the use of a web-based monitoring system called TELEmedicine to remotely monitor changes in patient activation and self-efficacy for inflammatory bowel disease (IBD) patients. This multicenter, randomized controlled trial enrolled 222 adults with IBD who had experienced an IBD flare within 2 years prior to the trial. Changes in self-efficacy were not significantly different between the two groups although patient activation scores were.
AHRQ-funded; HS018975.
Citation: Bilgrami Z, Abutaleb A, Chudy-Onwugaje K .
Effect of TELEmedicine for inflammatory bowel disease on patient activation and self-efficacy.
Dig Dis Sci 2020 Jan;65(1):96-103. doi: 10.1007/s10620-018-5433-5..
Keywords: Telehealth, Digestive Disease and Health, Patient Self-Management, Care Management, Health Information Technology (HIT), Patient and Family Engagement
Chuang LS, Villaverde N, Hui KY
A frameshift in CSF2RB predominant among Ashkenazi Jews increases risk for Crohn's disease and reduces monocyte signaling via GM-CSF.
The authors sought to identify rare, Crohn's disease-associated frameshift variants of high functional and statistical effects. They associated Crohn's disease with a frameshift mutation in CSF2RB. Intestinal monocytes from carriers of this mutation had reduced responses to granulocyte-macrophage colony-stimulating factor.
AHRQ-funded; HS021747.
Citation: Chuang LS, Villaverde N, Hui KY .
A frameshift in CSF2RB predominant among Ashkenazi Jews increases risk for Crohn's disease and reduces monocyte signaling via GM-CSF.
Gastroenterology 2016 Oct;151(4):710-23.e2. doi: 10.1053/j.gastro.2016.06.045.
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Keywords: Digestive Disease and Health, Genetics, Risk, Racial and Ethnic Minorities