National Healthcare Quality and Disparities Report
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AHRQ Research Studies
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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
Results
1 to 23 of 23 Research Studies DisplayedChudy-Onwugaje K, Abutaleb A, Buchwald A
Age modifies the association between depressive symptoms and adherence to self-testing with telemedicine in patients with inflammatory bowel disease.
This study researched the association between age and increased depressive symptoms and adherence to self-testing with telemedicine in patients with inflammatory bowel disease (IBD). It was found that patients 40 and older had worse adherence than patients younger than 40 with depressive symptoms.
AHRQ-funded; HS018975.
Citation: Chudy-Onwugaje K, Abutaleb A, Buchwald A .
Age modifies the association between depressive symptoms and adherence to self-testing with telemedicine in patients with inflammatory bowel disease.
Inflamm Bowel Dis 2018 Nov 29;24(12):2648-54. doi: 10.1093/ibd/izy194..
Keywords: Chronic Conditions, Depression, Digestive Disease and Health, Patient Adherence/Compliance, Patient Self-Management, Telehealth
Balentine CJ, Kenzik K, Chu DI
Planning post-discharge destination for gastrointestinal surgery patients: room for improvement?
Investigators compared short-term recovery for patients discharged to inpatient rehabilitation versus skilled nursing facilities after gastrointestinal surgery. They found that there was no difference in 30-day readmission rates, but post-discharge mortality was higher for patients discharged to skilled nursing facilities compared to inpatient rehabilitation.
AHRQ-funded; HS023009.
Citation: Balentine CJ, Kenzik K, Chu DI .
Planning post-discharge destination for gastrointestinal surgery patients: room for improvement?
Am J Surg 2018 Nov;216(5):912-18. doi: 10.1016/j.amjsurg.2018.05.004..
Keywords: Hospital Discharge, Surgery, Digestive Disease and Health, Rehabilitation, Nursing Homes, Quality Improvement, Quality of Care, Transitions of Care
D'Agata EMC, Varu A, Geffert SF
Acquisition of multidrug-resistant organisms in the absence of antimicrobials.
This nested case-control study was conducted among 137 nursing home residents who did not receive antimicrobials, with 44 acquiring a multi-drug resistant organism. Risk factors identified included receiving gastrointestinal medication that affected the gut microbiome, the number of visits from healthcare workers, pressure ulcers, and not residing in a dementia unit.
AHRQ-funded; HS021666.
Citation: D'Agata EMC, Varu A, Geffert SF .
Acquisition of multidrug-resistant organisms in the absence of antimicrobials.
Clin Infect Dis 2018 Oct 15;67(9):1437-40. doi: 10.1093/cid/ciy358..
Keywords: Antimicrobial Stewardship, Antibiotics, Medication, Nursing Homes, Long-Term Care, Elderly, Digestive Disease and Health, Case Study
Li D, Haritunians T, Landers C
Late-onset Crohn's Disease is a subgroup distinct in genetic and behavioral risk factors with UC-like characteristics.
Age of onset is linked to variations in clinical phenotypes and natural history in Crohn's disease (CD). In this study, the investigators aimed to define etiologically more homogenous subgroups in CD based on ages of onset. The investigators concluded that late-onset CD was subgroup distinct in genetic and behavioral risk factors with UC-like characteristics.
AHRQ-funded; HS021747.
Citation: Li D, Haritunians T, Landers C .
Late-onset Crohn's Disease is a subgroup distinct in genetic and behavioral risk factors with UC-like characteristics.
Inflamm Bowel Dis 2018 Oct 12;24(11):2413-22. doi: 10.1093/ibd/izy148..
Keywords: Digestive Disease and Health, Risk, Genetics
Abutaleb A, Buchwald A, Chudy-Onwugaje K
Inflammatory bowel disease telemedicine clinical trial: impact of educational text messages on disease-specific knowledge over 1 year.
The authors aimed to determine if delivery of educational messages through a telemedicine system improves inflammatory bowel disease (IBD) knowledge. They found that, although telemedicine improves IBD-specific knowledge through text messaging, telemedicine is not superior to education given through standard visits at referral centers.
AHRQ-funded; HS018975.
Citation: Abutaleb A, Buchwald A, Chudy-Onwugaje K .
Inflammatory bowel disease telemedicine clinical trial: impact of educational text messages on disease-specific knowledge over 1 year.
Inflamm Bowel Dis 2018 Sep 15;24(10):2191-97. doi: 10.1093/ibd/izy149..
Keywords: Telehealth, Health Information Technology (HIT), Digestive Disease and Health, Education: Patient and Caregiver, Health Literacy, Quality of Life
Symer MM, Abelson JS, Sedrakyan A
Early operative management of complicated appendicitis is associated with improved surgical outcomes in adults.
In this study, the New York State Planning and Research Cooperative database was used to identify all patients admitted with complicated appendicitis and undergoing appendectomy within 1-year. Primary outcome was any complication. Secondary outcomes included length of stay (LOS), hospital charges, and laparoscopy use. Outcomes were compared in appendectomy before or after 48h from admission. The investigators found more complications, longer LOS, and higher charges in patients undergoing delayed surgery.
AHRQ-funded; HS000066.
Citation: Symer MM, Abelson JS, Sedrakyan A .
Early operative management of complicated appendicitis is associated with improved surgical outcomes in adults.
Am J Surg 2018 Sep;216(3):431-37. doi: 10.1016/j.amjsurg.2018.04.010..
Keywords: Surgery, Digestive Disease and Health, Outcomes
Clerc F, Novokmet M, Dotz V
Plasma N-glycan signatures are associated with features of inflammatory bowel diseases.
Biomarkers are needed for early detection of Crohn's disease (CD) and ulcerative colitis (UC) or to predict patient outcomes. This study compared plasma N-glycosylation profiles between patients with Crohn's disease (CD) or ulcerative colitis (UC) and healthy individuals (controls).
AHRQ-funded; HS021747.
Citation: Clerc F, Novokmet M, Dotz V .
Plasma N-glycan signatures are associated with features of inflammatory bowel diseases.
Gastroenterology 2018 Sep;155(3):829-43. doi: 10.1053/j.gastro.2018.05.030..
Keywords: Digestive Disease and Health, Outcomes
Egberg MD, Gulati AS, Gellad ZF
Improving quality in the care of patients with inflammatory bowel diseases.
In this article, the authors reviewed the history of quality initiatives in healthcare and identified ongoing gaps in inflammatory bowel disease (IBD) care with a review of current IBD improvement efforts taking place. Several targets for improving IBD care quality while moving forward into the 21st century were also identified.
AHRQ-funded; HS000063.
Citation: Egberg MD, Gulati AS, Gellad ZF .
Improving quality in the care of patients with inflammatory bowel diseases.
Inflamm Bowel Dis 2018 Jul 12;24(8):1660-69. doi: 10.1093/ibd/izy030..
Keywords: Digestive Disease and Health, Quality of Care, Quality Improvement
Gephart SM, Wyles C, Canvasser J
Expert consensus to weight an adherence score for audit and feedback of practices that prevent necrotizing enterocolitis in very low birth weight infants.
Necrotizing enterocolitis (NEC) is a catastrophic abdominal complication threatening the life of premature infants, but adoption of prevention and early recognition practices differs as do NEC rates in Neonatal Intensive Care Units (NICUs). The purpose of this research was to validate and weight an evidence-based adherence score (aka NEC-Zero Adherence Score) to prevent and foster timely recognition of NEC.
AHRQ-funded; HS022908.
Citation: Gephart SM, Wyles C, Canvasser J .
Expert consensus to weight an adherence score for audit and feedback of practices that prevent necrotizing enterocolitis in very low birth weight infants.
Appl Nurs Res 2018 Feb;39:182-88. doi: 10.1016/j.apnr.2017.11.021..
Keywords: Newborns/Infants, Digestive Disease and Health, Diagnostic Safety and Quality, Intensive Care Unit (ICU)
Dulai PS, Siegel CA
Optimization of drug safety profile in inflammatory bowel disease through a personalized approach.
Treatment strategies and treatment options have changed considerably over the past decade for Inflammatory Bowel Disease (IBD). In this review the authors discuss the potential risks of therapy in IBD, opportunities to mitigate those risks, and a personalized approach to consider when using these agents in clinical practice.
AHRQ-funded; HS021747.
Citation: Dulai PS, Siegel CA .
Optimization of drug safety profile in inflammatory bowel disease through a personalized approach.
Curr Drug Targets 2018;19(7):740-47. doi: 10.2174/1389450118666170525114939..
Keywords: Adverse Drug Events (ADE), Adverse Events, Decision Making, Digestive Disease and Health, Medication, Patient-Centered Healthcare
Aggarwal R, Brown KM, de Groen PC
AHRQ Author: Henriksen K
Simulation research in gastrointestinal and urologic care-challenges and opportunities: summary of a National Institute of Diabetes and Digestive and Kidney Diseases and National Institute of Biomedical Imaging and Bioengineering workshop.
The purpose of the workshop was to examine the extent to which simulation approaches have been used by skilled proceduralists (not trainees) caring for patients with gastrointestinal and urologic diseases. The current status of research findings in the use and effectiveness of simulation applications was reviewed, and numerous knowledge gaps and research needs were identified by the faculty and the attendees.
AHRQ-authored.
Citation: Aggarwal R, Brown KM, de Groen PC .
Simulation research in gastrointestinal and urologic care-challenges and opportunities: summary of a National Institute of Diabetes and Digestive and Kidney Diseases and National Institute of Biomedical Imaging and Bioengineering workshop.
Ann Surg 2018 Jan;267(1):26-34. doi: 10.1097/sla.0000000000002228.
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Keywords: Digestive Disease and Health, Education: Continuing Medical Education, Evidence-Based Practice, Research Methodologies
Gephart SM, Hanson C, Wetzel CM
NEC-zero recommendations from scoping review of evidence to prevent and foster timely recognition of necrotizing enterocolitis.
The purpose of this paper is to present a scoping review with two new meta-analyses, clinical recommendations, and implementation strategies to prevent and foster timely recognition of necrotizing enterocolitis. The researchers conducted a stakeholder-engaged scoping review to classify strength of evidence and form implementation recommendations across subgroup areas: 1) promoting human milk, 2) feeding protocols and transfusion, 3) timely recognition strategies, and 4) medication stewardship.
AHRQ-funded; HS022908.
Citation: Gephart SM, Hanson C, Wetzel CM .
NEC-zero recommendations from scoping review of evidence to prevent and foster timely recognition of necrotizing enterocolitis.
Matern Health Neonatol Perinatol 2017 Dec;3:23. doi: 10.1186/s40748-017-0062-0.
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Keywords: Adverse Events, Digestive Disease and Health, Guidelines, Newborns/Infants, Prevention
Leeds IL, Canner JK, Efron JE
The independent effect of cancer on outcomes: a potential limitation of surgical risk prediction.
This study aims to compare the use of common risk models for benign versus malignant gastrointestinal disease. It found that the National Surgical Quality Improvement Program (NSQIP) prediction models less effectively evaluate the risk of death in cancer patients as compared to patients with benign disease. A diagnosis of cancer is independently associated with an increased risk of surgical complications.
AHRQ-funded; HS024736.
Citation: Leeds IL, Canner JK, Efron JE .
The independent effect of cancer on outcomes: a potential limitation of surgical risk prediction.
J Surg Res 2017 Dec;220:402-09.e6. doi: 10.1016/j.jss.2017.08.039.
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Keywords: Adverse Events, Cancer, Digestive Disease and Health, Risk, Surgery
Balbale SN, Trivedi I, O'Dwyer LC
Strategies to identify and reduce opioid misuse among patients with gastrointestinal disorders: a systematic scoping review.
In this study, the investigators conducted a systematic scoping review to describe published scientific literature on strategies to identify and reduce opioid misuse among patients with gastrointestinal (GI) symptoms and disorders. They concluded that prescription drug monitoring and self-management interventions may be promising strategies to identify and reduce opioid misuse in GI care. They suggest that rigorous, empirical research is needed to evaluate the longer-term impact of these strategies.
AHRQ-funded; HS000084.
Citation: Balbale SN, Trivedi I, O'Dwyer LC .
Strategies to identify and reduce opioid misuse among patients with gastrointestinal disorders: a systematic scoping review.
Dig Dis Sci 2017 Oct;62(10):2668-85. doi: 10.1007/s10620-017-4705-9..
Keywords: Behavioral Health, Chronic Conditions, Digestive Disease and Health, Medication, Medication: Safety, Opioids, Patient Self-Management, Prevention, Substance Abuse
Symer MM, Abelson JS, Milsom J
A mobile health application to track patients after gastrointestinal surgery: results from a pilot study.
Many surgical readmissions are preventable. Mobile health technology can identify nascent complications and potentially prevent readmission. The researchers performed a pilot study of a new mobile health application in adults undergoing major abdominal surgery and determined the app can track patient recovery from major abdominal surgery, is easy to use, and has potential to improve outcomes.
AHRQ-funded; HS000066.
Citation: Symer MM, Abelson JS, Milsom J .
A mobile health application to track patients after gastrointestinal surgery: results from a pilot study.
J Gastrointest Surg 2017 Sep;21(9):1500-05. doi: 10.1007/s11605-017-3482-2..
Keywords: Telehealth, Health Information Technology (HIT), Hospital Readmissions, Surgery, Adverse Events, Patient Safety, Digestive Disease and Health, Prevention
Feuille E, Menon NR, Huang F
Knowledge of food protein-induced enterocolitis syndrome among general pediatricians.
In this study, investigators examined knowledge of food protein-induced enterocolitis syndrome among general pediatricians. They created a 32-question survey, collecting information regarding participants’ experience with FPIES and knowledge of FPIES diagnosis and management. Investigators found that many pediatricians had a basic but incomplete understanding of FPIES diagnosis and initial management.
AHRQ-funded; HS024599.
Citation: Feuille E, Menon NR, Huang F .
Knowledge of food protein-induced enterocolitis syndrome among general pediatricians.
Ann Allergy Asthma Immunol 2017 Sep;119(3):291-92.e3. doi: 10.1016/j.anai.2017.07.001..
Keywords: Children/Adolescents, Digestive Disease and Health, Diagnostic Safety and Quality, Nutrition, Provider, Provider: Clinician, Provider: Physician
Karkar R, Schroeder J, Epstein DA
Tummytrials: a feasibility study of using self-experimentation to detect individualized food triggers.
The researchers designed, developed, and evaluated a mobile app that applies a self experimentation framework to support patients suffering from irritable bowel syndrome (IBS) in identifying their personal food triggers. In examining the feasibility of this approach in a field study with 15 IBS patients, they found that participants could use the tool to reliably undergo a self-experiment.
AHRQ-funded; HS023654.
Citation: Karkar R, Schroeder J, Epstein DA .
Tummytrials: a feasibility study of using self-experimentation to detect individualized food triggers.
Proc SIGCHI Conf Hum Factor Comput Syst 2017 May 2:6850-63. doi: 10.1145/3025453.3025480..
Keywords: Digestive Disease and Health, Health Information Technology (HIT), Nutrition, Patient Self-Management
Bounthavong M, Li M, Watanabe JH
An evaluation of health care expenditures in Crohn's disease using the United States Medical Expenditure Panel Survey from 2003 to 2013.
The goal of this study was to update cost estimates of Crohn's disease based on a representative sample of the US population from the most recent 11 years (2003-2013) of the Medical Expenditure Panel Survey (MEPS). A secondary aim was to describe expenditure trends in respondents with and without Crohn's disease pre-post FDA approvals of new biologics and the American College of Gastroenterology Crohn's disease treatment guidelines.
AHRQ-funded; HS013853.
Citation: Bounthavong M, Li M, Watanabe JH .
An evaluation of health care expenditures in Crohn's disease using the United States Medical Expenditure Panel Survey from 2003 to 2013.
Res Social Adm Pharm 2017 May-Jun;13(3):530-38. doi: 10.1016/j.sapharm.2016.05.042..
Keywords: Healthcare Costs, Digestive Disease and Health, Medical Expenditure Panel Survey (MEPS)
Stone B, Hester G, Jackson D
Effectiveness of fundoplication or gastrojejunal feeding in children with neurologic impairment.
Gastroesophageal reflux (GER), aspiration, and secondary complications lead to morbidity and mortality in children with neurologic impairment (NI), dysphagia, and gastrostomy feeding. Fundoplication and gastrojejunal (GJ) feeding can reduce risk. A comparison of GJ to fundoplication using first-year postprocedure reflux-related hospitalization (RRH) rates found that in children with NI, GER, and dysphagia,:fundoplication and GJ feeding have similar RRH outcomes.
AHRQ-funded; HS019862.
Citation: Stone B, Hester G, Jackson D .
Effectiveness of fundoplication or gastrojejunal feeding in children with neurologic impairment.
Hosp Pediatr 2017 Mar;7(3):140-48. doi: 10.1542/hpeds.2016-0126.
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Keywords: Children/Adolescents, Digestive Disease and Health, Neurological Disorders, Nutrition, Outcomes, Treatments
Predmore Z, Nie X, Main R
Anesthesia service use during outpatient gastroenterology procedures continued to increase from 2010 to 2013 and potentially discretionary spending remained high.
Previous studies have identified an increasing number of gastroenterology (GI) procedures using anesthesia services to provide sedation, with a majority of these services delivered to low-risk patients. The aim of this study was to update these trends with the most recent years of data. It found that during 2010 to 2013, anesthesia service use in GI procedures continued to increase and the proportion of these services rendered for low-risk patients remained high.
AHRQ-funded; HS000029.
Citation: Predmore Z, Nie X, Main R .
Anesthesia service use during outpatient gastroenterology procedures continued to increase from 2010 to 2013 and potentially discretionary spending remained high.
Am J Gastroenterol 2017 Feb;112(2):297-302. doi: 10.1038/ajg.2016.266.
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Keywords: Digestive Disease and Health, Ambulatory Care and Surgery, Healthcare Costs
Banerjee T, Meyer TW, Shafi T
Free and total p-cresol sulfate levels and infectious hospitalizations in hemodialysis patients in CHOICE and HEMO.
P-cresol sulfate (PCS), a prototype protein-bound uremic retention solute, has been shown to exert toxic effects in vitro. The researchers explored the relationship between free and total PCS and indoxyl sulfate (IS) with infection-related hospitalizations (IH) and septicemia in 2 cohorts. Their results suggest an association between higher concentrations of free PCS and infection-related and sepsis-related hospitalizations in hemodialysis patients.
AHRQ-funded; HS008365.
Citation: Banerjee T, Meyer TW, Shafi T .
Free and total p-cresol sulfate levels and infectious hospitalizations in hemodialysis patients in CHOICE and HEMO.
Medicine 2017 Feb;96(6):e5799. doi: 10.1097/md.0000000000005799.
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Keywords: Hospitalization, Kidney Disease and Health, Kidney Disease and Health, Digestive Disease and Health, Sepsis
Schroeder J, Hoffswell J, Chung CF
Supporting patient-provider collaboration to identify individual triggers using food and symptom journals.
The researchers examined patient-provider collaboration to interpret patient-generated data. Irritable bowel syndrome (IBS) management often requires patient-provider collaboration using a patient's food and symptom journal to identify the patient's triggers. Drawing upon individual and collaborative interviews with patients and providers, the researchers found that collaborative review helps improve data comprehension and build mutual trust.
AHRQ-funded; HS023654.
Citation: Schroeder J, Hoffswell J, Chung CF .
Supporting patient-provider collaboration to identify individual triggers using food and symptom journals.
CSCW 2017 Feb 25;2017:1726-39. doi: 10.1145/2998181.2998276.
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Keywords: Digestive Disease and Health, Health Information Technology (HIT), Nutrition, Clinician-Patient Communication, Patient Self-Management
Zia JK, Chung CF, Schroeder J
The feasibility, usability, and clinical utility of traditional paper food and symptom journals for patients with irritable bowel syndrome.
The primary aim of this study was to evaluate the feasibility, usability, and clinical utility of paper food and gastrointestinal symptom journals as a data collection tool. Over half of the 17 participants perceived paper journaling of food and symptoms as feasible, usable, and clinically useful. Thirteen participants demonstrated a strong association with at least one symptom and meal nutrient.
AHRQ-funded; HS023654.
Citation: Zia JK, Chung CF, Schroeder J .
The feasibility, usability, and clinical utility of traditional paper food and symptom journals for patients with irritable bowel syndrome.
Neurogastroenterol Motil 2017 Feb;29(2). doi: 10.1111/nmo.12935.
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Keywords: Digestive Disease and Health, Nutrition, Patient Experience, Patient Self-Management