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AHRQ Research Studies
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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
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1 to 4 of 4 Research Studies DisplayedLandes SJ, Kerns SEU, Pilar MR
Proceedings of the Fifth Biennial Conference of the Society for Implementation Research Collaboration (SIRC) 2019: where the rubber meets the road: the intersection of research, policy, and practice - part 1.
This paper offers a compilation of the abstracts of the oral and poster presentations from the 2019 Society for Implementation Research Collaboration (SIRC) Conference entitled “Where the Rubber Meets the Road: The Intersection of Research, Policy, and Practice” held in Seattle from 12-14 September. The society had evolved following a NIMH-funded conference grant and is now an international society. The conference included 432 attendees. Highlights of the conference are described.
AHRQ-funded; HS025632.
Citation: Landes SJ, Kerns SEU, Pilar MR .
Proceedings of the Fifth Biennial Conference of the Society for Implementation Research Collaboration (SIRC) 2019: where the rubber meets the road: the intersection of research, policy, and practice - part 1.
Implement Sci 2020 Sep 30;15(Suppl 3):76. doi: 10.1186/s13012-020-01034-7..
Keywords: Implementation, Health Services Research (HSR), Evidence-Based Practice, Policy, Research Methodologies
Lewis CC, Boyd MR, Walsh-Bailey C
A systematic review of empirical studies examining mechanisms of implementation in health.
The authors conducted this systematic review to characterize how mechanisms are conceptualized and measured, how they are studied and evaluated, and how much evidence exists for specific mechanisms. They found that researchers have undertaken a multitude of approaches to pursue mechanistic implementation research, but this review revealed substantive conceptual, methodological, and measurement issues that must be addressed in order to advance their research agenda. They recommend greater precision to achieve conceptual clarity, testable hypotheses about how and why variables are related, and concrete behavioral indicators of proximal outcomes in the case of quantitative research and more directed inquiry in the case of qualitative research.
AHRQ-funded; HS025632.
Citation: Lewis CC, Boyd MR, Walsh-Bailey C .
A systematic review of empirical studies examining mechanisms of implementation in health.
Implement Sci 2020 Apr 16;15(1):21. doi: 10.1186/s13012-020-00983-3..
Keywords: Research Methodologies, Implementation
Fiscella K, Sanders M, Holder T
The role of data and safety monitoring boards in implementation trials: when are they justified?
This paper examined the appropriateness of the establishment of data and safety monitoring boards (DSMBs) for all phase III clinical trials sponsored by the National Heart, Lung and Blood Institute (NHLBI). The authors reviewed the unique features of implementation trials and reflected on key questions regarding the justification for DSMBs and their potential role and monitoring targets within implementation trials.
AHRQ-funded; HS021667.
Citation: Fiscella K, Sanders M, Holder T .
The role of data and safety monitoring boards in implementation trials: when are they justified?
J Clin Transl Sci 2020 Mar 5;4(3):229-32. doi: 10.1017/cts.2020.19..
Keywords: Research Methodologies, Implementation
Gaynes BN, Lux L, Gartlehner G
Defining treatment-resistant depression.
The authors conducted a review for the Centers for Medicare & Medicaid Services and AHRQ to clarify how experts and investigators have defined treatment-resistant depression (TRD) and to review systematically how well this definition comports with TRD definitions in clinical trials through July 5, 2019. They found that no consensus definition existed for TRD. While depressive outcomes and clinical global impressions were commonly measured, functional impairment and quality-of-life tools were rarely used. They recommend stronger approaches to designing and conducting TRD research in order to foster better evidence to translate into clearer guidelines for treating patients with TRD.
AHRQ-funded; 290201500011I.
Citation: Gaynes BN, Lux L, Gartlehner G .
Defining treatment-resistant depression.
Depress Anxiety 2020 Feb;37(2):134-45. doi: 10.1002/da.22968..
Keywords: Depression, Behavioral Health, Evidence-Based Practice, Implementation, Research Methodologies