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Search All Research Studies
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- Children/Adolescents (1)
- Comparative Effectiveness (1)
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- (-) Medication (7)
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- (-) Obesity: Weight Management (7)
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AHRQ Research Studies
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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
Results
1 to 7 of 7 Research Studies DisplayedHuo T, Li Q, Cardel MI
AHRQ Author: Mistry K
Enhancing quality measurement with clinical information: a use case of body mass index change among children taking second generation antipsychotics.
The authors sought to examine the extent to which body mass index (BMI) was available in electronic health records for Florida Medicaid recipients aged 5 to 18 years taking Second-Generation Antipsychotics (SGAP). They concluded that meeting the 2030 CMS goal of digital monitoring of quality of care will require continuing expansion of clinical encounter data capture to provide the data needed for digital quality monitoring. Using linked electronic health records and claims data allows identifying children at higher risk for SGAP-induced weight gain.
AHRQ-authored; AHRQ-funded; HS025298.
Citation: Huo T, Li Q, Cardel MI .
Enhancing quality measurement with clinical information: a use case of body mass index change among children taking second generation antipsychotics.
Acad Pediatr 2022 Apr;22(3S):S140-S49. doi: 10.1016/j.acap.2021.11.012..
Keywords: Children/Adolescents, Electronic Health Records (EHRs), Health Information Technology (HIT), Medication, Obesity, Obesity: Weight Management, Quality Measures, Quality of Care
Howard R, Chao GF, Yang J
Medication use for obesity-related comorbidities after sleeve gastrectomy or gastric bypass.
The purpose of this comparative effectiveness research study was to evaluate prior laparoscopic sleeve gastrectomy or Roux-en-Y gastric bypass patients and compare the incidence of medication discontinuation and restart of diabetes, hypertension, and hyperlipidemia medications. The researchers reviewed the records of adult Medicare beneficiaries who underwent sleeve gastrectomy or gastric bypass between January 1, 2012, to December 31, 2018, and had a claim for diabetes, hypertension, or hyperlipidemia medication in the 6 months before surgery with a corresponding diagnosis. The study found that when compared with sleeve gastrectomy, gastric bypass was associated with a slightly higher 5-year cumulative incidence of medication discontinuation among 30,588 patients with diabetes medication use and diagnosis at the time of surgery, 5,081 patients with antihypertensive medication use and diagnosis at the time of surgery and 35,055 patients with lipid-lowering medication use and diagnosis at the time of surgery. Among the patients who discontinued medication, gastric bypass was also associated with a slightly lower incidence of medication restart up to 5 years after discontinuation. The researchers concluded that gastric bypass was associated with a slightly higher incidence of medication discontinuation and a slightly lower incidence of medication restart among patients who discontinued medication than sleeve gastrectomy.
AHRQ-funded; HS025778; HS025365.
Citation: Howard R, Chao GF, Yang J .
Medication use for obesity-related comorbidities after sleeve gastrectomy or gastric bypass.
JAMA Surg 2022 Mar;157(3):248-56. doi: 10.1001/jamasurg.2021.6898..
Keywords: Obesity, Obesity: Weight Management, Surgery, Medication
Bourgi K, Jenkins CA, Rebeiro PF
Weight gain among treatment-naive persons with HIV starting integrase inhibitors compared to non-nucleoside reverse transcriptase inhibitors or protease inhibitors in a large observational cohort in the United States and Canada.
This study compared weight gain among persons with HIV (PWH) following different antiretroviral therapy (ART) drug classes. The cohort was part of the North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD). The 22,972 participants were 87% male and 41% white. Twenty percent started strand transfer inhibitor (INSTI), 31% started protease inhibitor (PI), and 49% started non-nucleoside reverse-transcriptase inhibitor (NNRTI)-based ART. Average weight gain was higher with INSTI-based regimens compared to NNRTI-based regimens or PI-based regimens.
AHRQ-funded; 90047713.
Citation: Bourgi K, Jenkins CA, Rebeiro PF .
Weight gain among treatment-naive persons with HIV starting integrase inhibitors compared to non-nucleoside reverse transcriptase inhibitors or protease inhibitors in a large observational cohort in the United States and Canada.
J Int AIDS Soc 2020 Apr;23(4):e25484. doi: 10.1002/jia2.25484.
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Keywords: Human Immunodeficiency Virus (HIV), Obesity: Weight Management, Obesity, Medication
Smith ME, Lee JS, Bonham A
Effect of new persistent opioid use on physiologic and psychologic outcomes following bariatric surgery.
In this study, the investigators sought to determine the relationship between new persistent opioid use and 1-year postoperative outcomes for patients undergoing bariatric surgery. The investigators concluded that new persistent opioid use is common following bariatric surgery and associated with significantly worse physiologic and psychologic outcomes. More effective screening and postoperative surveillance tools are needed to identify these patients, who likely require more aggressive counseling and treatment to maximize the benefits of bariatric surgery.
AHRQ-funded; HS024403.
Citation: Smith ME, Lee JS, Bonham A .
Effect of new persistent opioid use on physiologic and psychologic outcomes following bariatric surgery.
Surg Endosc 2019 Aug;33(8):2649-56. doi: 10.1007/s00464-018-6542-0..
Keywords: Opioids, Surgery, Medication, Obesity: Weight Management, Obesity, Obesity: Weight Management, Pain, Outcomes
Herrin M, Tate JP, Akgun KM
Weight gain and incident diabetes among HIV-infected veterans initiating antiretroviral therapy compared with uninfected individuals.
The authors used data from the Veterans Aging Cohort Study to determine whether weight gain after antiretroviral therapy has a similar association with incident type 2 diabetes mellitus as weight gained among HIV-uninfected individuals. They found that weight gained during the first year after antiretroviral therapy initiation is associated with greater risk of diabetes mellitus than that among uninfected individuals.
AHRQ-funded; HS018372.
Citation: Herrin M, Tate JP, Akgun KM .
Weight gain and incident diabetes among HIV-infected veterans initiating antiretroviral therapy compared with uninfected individuals.
J Acquir Immune Defic Syndr 2016 Oct 1;73(2):228-36. doi: 10.1097/qai.0000000000001071.
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Keywords: Diabetes, Human Immunodeficiency Virus (HIV), Medication, Obesity: Weight Management
Romanelli RJ, Chung S, Pu J
Comparative effectiveness of early versus delayed metformin in the treatment of type 2 diabetes.
The purpose of this study was to quantify the effectiveness of early versus delayed initiation of metformin monotherapy on glycemic control (measured by change in HbA1c) and weight modification (change in body mass index [BMI]). It found that treatment with metformin earlier in the course of type 2 diabetes is associated with better glycemic control, more pronounced weight reduction, and a lower risk for therapy intensification than delayed treatment.
AHRQ-funded; HS019815.
Citation: Romanelli RJ, Chung S, Pu J .
Comparative effectiveness of early versus delayed metformin in the treatment of type 2 diabetes.
Diabetes Res Clin Pract 2015 Apr;108(1):170-8. doi: 10.1016/j.diabres.2014.12.019..
Keywords: Diabetes, Medication, Comparative Effectiveness, Obesity: Weight Management, Outcomes
Daubresse M, Alexander GC
The uphill battle facing antiobesity drugs.
The authors argue that the barriers faced by individual anorectic products belie larger regulatory and clinical challenges to their mainstream adoption, and contribute to the irony that despite American’s penchant for high rates of pharmaceutical use, obesity drugs have fared remarkably poorly in the market.
AHRQ-funded; HS0189960.
Citation: Daubresse M, Alexander GC .
The uphill battle facing antiobesity drugs.
Int J Obes 2015 Mar;39(3):377-8. doi: 10.1038/ijo.2014.169..
Keywords: Obesity, Medication, Obesity: Weight Management, Policy