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AHRQ Research Studies
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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
Results
576 to 600 of 699 Research Studies DisplayedRocque GB, Taylor RA, Acemgil A
Guiding lay navigation in geriatric patients with cancer using a distress assessment tool.
This study assessed the feasibility and impact of using distress assessments to frame lay navigator interactions with geriatric patients with cancer who were enrolled in navigation between January 1, 2014, and December 31, 2014. It concluded that lay navigators were able to routinely screen for patient distress at a high degree of penetration using a structured distress assessment.
AHRQ-funded; HS013852.
Citation: Rocque GB, Taylor RA, Acemgil A .
Guiding lay navigation in geriatric patients with cancer using a distress assessment tool.
J Natl Compr Canc Netw 2016 Apr;14(4):407-14.
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Keywords: Elderly, Cancer, Tools & Toolkits, Stress, Behavioral Health
Watkins KE, Smith B, Akincigil A
The quality of medication treatment for mental disorders in the department of Veterans Affairs and in private-sector plans.
The objective of this paper was to compare the quality of mental health care provided by the U.S. Department of Veterans Affairs (VA) with care provided to a comparable population treated in the private sector. The researchers found that VA performance was superior to that of the private sector by more than 30%. They concluded that their findings demonstrate the significant advantages that accrue from an organized, nationwide system of care and suggested that the much higher performance of the VA has important clinical and policy implications.
AHRQ-funded; HS003258; HS021112.
Citation: Watkins KE, Smith B, Akincigil A .
The quality of medication treatment for mental disorders in the department of Veterans Affairs and in private-sector plans.
Psychiatr Serv 2016 Apr;67(4):391-6. doi: 10.1176/appi.ps.201400537.
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Keywords: Quality of Care, Health Insurance, Medication, Behavioral Health
O'Connor BC, Lewandowski RE, Rodriguez S
Usual care for adolescent depression from symptom identification through treatment initiation.
The researchers sought to determine rates of appropriate follow-up care for adolescents with newly identified depression symptoms in 3 large health systems. They concluded that most adolescents with newly identified depression symptoms received some treatment, usually including psychotherapy, within the first 3 months after identification. However, follow-up care was low and substantial variation existed between sites.
AHRQ-funded; HS020503.
Citation: O'Connor BC, Lewandowski RE, Rodriguez S .
Usual care for adolescent depression from symptom identification through treatment initiation.
JAMA Pediatr 2016 Apr;170(4):373-80. doi: 10.1001/jamapediatrics.2015.4158.
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Keywords: Medication, Children/Adolescents, Depression, Behavioral Health
Gartlehner G, Gaynes BN, Amick HR
Comparative benefits and harms of antidepressant, psychological, complementary, and exercise treatments for major depression: An evidence report for a clinical practice guideline from the American College of Physicians.
This evidence report compared the benefits and harms of second-generation antidepressants and psychological, complementary and alternative medicine (CAM), and exercise treatments as first- and second-step interventions for adults with acute major depressive disorder (MDD). It concluded tht, given their similar efficacy, cognitive behavioral therapy and antidepressants are both viable choices for initial treatment of MDD.
AHRQ-funded.
Citation: Gartlehner G, Gaynes BN, Amick HR .
Comparative benefits and harms of antidepressant, psychological, complementary, and exercise treatments for major depression: An evidence report for a clinical practice guideline from the American College of Physicians.
Ann Intern Med 2016 Mar 1;164(5):331-41. doi: 10.7326/m15-1813.
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Keywords: Medication, Comparative Effectiveness, Complementary and Alternative Medicine, Depression, Behavioral Health
Domino ME, Jackson C, Beadles CA
Do primary care medical homes facilitate care transitions after psychiatric discharge for patients with multiple chronic conditions?
The purpose of this manuscript is to assess outpatient follow-up rates with primary care and mental health providers following psychiatric discharge by medical home enrollment and medical complexity. Hospitalized persons with multiple chronic conditions including serious mental illness enrolled in a medical home were more likely to receive timely outpatient follow-up with a primary care provider but not with a mental health specialist.
AHRQ-funded; HS000032; HS019659.
Citation: Domino ME, Jackson C, Beadles CA .
Do primary care medical homes facilitate care transitions after psychiatric discharge for patients with multiple chronic conditions?
Gen Hosp Psychiatry 2016 Mar-Apr;39:59-65. doi: 10.1016/j.genhosppsych.2015.11.002.
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Keywords: Primary Care, Patient-Centered Healthcare, Behavioral Health, Hospitalization, Chronic Conditions
Fiechtner L, Kleinman K, Melly SJ
Effects of proximity to supermarkets on a randomized trial studying interventions for obesity.
To determine whether proximity to a supermarket modified the effects of an obesity intervention, the researchers examined distance to the closest supermarket as an effect modifier.They concluded that living closer to a supermarket is associated with greater improvements in fruit and vegetable intake and weight status in an obesity intervention.
AHRQ-funded; HS022986.
Citation: Fiechtner L, Kleinman K, Melly SJ .
Effects of proximity to supermarkets on a randomized trial studying interventions for obesity.
Am J Public Health 2016 Mar;106(3):557-62. doi: 10.2105/ajph.2015.302986.
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Keywords: Obesity, Nutrition, Lifestyle Changes, Social Determinants of Health, Behavioral Health
Forman-Hoffman V, McClure E, McKeeman J
Screening for major depressive disorder in children and adolescents: a systematic review for the U.S. Preventive Services Task Force.
This report updates the 2009 U.S. Preventive Services Task Force (USPSTF) systematic review on screening for and treatment of Major depressive disorder (MDD) in children and adolescents in primary care settings. No evidence was found of a direct link between screening children and adolescents for MDD in primary care or similar settings and depression or other health-related outcomes. Evidence showed that some screening tools are accurate.
AHRQ-funded; 290201200015.
Citation: Forman-Hoffman V, McClure E, McKeeman J .
Screening for major depressive disorder in children and adolescents: a systematic review for the U.S. Preventive Services Task Force.
Ann Intern Med 2016 Mar 1;164(5):342-9. doi: 10.7326/m15-2259.
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Keywords: U.S. Preventive Services Task Force (USPSTF), Screening, Depression, Behavioral Health, Children/Adolescents
Hwang SW, Chambers C, Katic M
Accuracy of self-reported health care use in a population-based sample of homeless adults.
The objective of this study was to assess the accuracy of self-reported ambulatory care visits, emergency department (ED) encounters, and overnight hospitalizations in a population-based sample of homeless adults.It found that adults experiencing homelessness are quite accurate reporters of their use of health care, especially for ED encounters and hospitalizations.
AHRQ-funded; HS014129.
Citation: Hwang SW, Chambers C, Katic M .
Accuracy of self-reported health care use in a population-based sample of homeless adults.
Health Serv Res 2016 Feb. doi: 10.1111/1475-6773.12329..
Keywords: Hospitalization, Behavioral Health, Social Determinants of Health, Healthcare Utilization, Emergency Department
Liu L, Strawderman RL, Johnson BA
Analyzing repeated measures semi-continuous data, with application to an alcohol dependence study.
The authors reviewed and considered three extensions of two-part random effects models. They compared the performance through applications to daily drinking records in a secondary data analysis from a randomized controlled trial of topiramate for alcohol dependence treatment. They found that all three models provide a significantly better fit than the log-normal model, and there exists strong evidence for heteroscedasticity.
AHRQ-funded; HS020263.
Citation: Liu L, Strawderman RL, Johnson BA .
Analyzing repeated measures semi-continuous data, with application to an alcohol dependence study.
Stat Methods Med Res 2016 Feb;25(1):133-52. doi: 10.1177/0962280212443324.
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Keywords: Alcohol Use, Behavioral Health, Substance Abuse
Irvin VL, Kaplan RM
AHRQ Author: Kaplan RM
Effect sizes and primary outcomes in large-budget, cardiovascular-related behavioral randomized controlled trials funded by NIH since 1980.
The authors reviewed large-budget, National Institutes of Health (NIH)-supported randomized controlled trials (RCTs) with behavioral interventions to assess (1) publication rates, (2) trial registration, (3) use of objective measures, (4) significant behavior and physiological change, and (5) effect sizes. They concludedc that behavioral trials complied with trial registration standards. Most reported a physiological benefit, but few documented morbidity or mortality benefits.
AHRQ-authored.
Citation: Irvin VL, Kaplan RM .
Effect sizes and primary outcomes in large-budget, cardiovascular-related behavioral randomized controlled trials funded by NIH since 1980.
Ann Behav Med 2016 Feb;50(1):130-46. doi: 10.1007/s12160-015-9739-7.
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Keywords: Outcomes, Cardiovascular Conditions, Research Methodologies, Behavioral Health
Eichen DM, Kass AE, Fitzsimmons-Craft EE
Non-suicidal self-injury and suicidal ideation in relation to eating and general psychopathology among college-age women.
Limited research has examined the effects of combined non-suicidal self-injury (NSSI)+suicidal ideation; thus concurrent examination is needed to understand potential differential effects on psychopathology. In this study, college-aged women completed self-report measures of NSSI, suicidal ideation, general psychopathology, and Eating Disorder-specific psychopathology. The study found that the NSSI+Suicidal Ideation group was only greater than Suicidal Ideation-only on measures of depression and eating concern.
AHRQ-funded; HS000078.
Citation: Eichen DM, Kass AE, Fitzsimmons-Craft EE .
Non-suicidal self-injury and suicidal ideation in relation to eating and general psychopathology among college-age women.
Psychiatry Res 2016 Jan 30;235:77-82. doi: 10.1016/j.psychres.2015.11.046.
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Keywords: Behavioral Health, Nutrition, Depression, Risk
Finnerty M, Neese-Todd S, Pritam R
Access to psychosocial services prior to starting antipsychotic treatment among Medicaid-insured youth.
The researchers sought to examine rates and predictors of receiving a psychosocial service before initiating antipsychotic treatment among young people in the Medicaid program. They found that less than one-half of youth received a psychosocial service before initiating antipsychotic treatment, and youth diagnosed with stress disorders were significantly more likely than those diagnosed with psychotic or bipolar disorders to have received a psychosocial service before starting an antipsychotic. They concluded that this service pattern highlights a critical gap in access to psychosocial services.
AHRQ-funded; HS019937; HS020503; HS021112.
Citation: Finnerty M, Neese-Todd S, Pritam R .
Access to psychosocial services prior to starting antipsychotic treatment among Medicaid-insured youth.
J Am Acad Child Adolesc Psychiatry 2016 Jan;55(1):69-76.e3. doi: 10.1016/j.jaac.2015.09.020.
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Keywords: Access to Care, Children/Adolescents, Medication, Behavioral Health
Deckersbach T, Nierenberg AA, McInnis MG
Baseline disability and poor functioning in bipolar disorder predict worse outcomes: results from the Bipolar CHOICE study.
This study examined the effects of treatment on functioning impairments and quality of life and assessed baseline functioning and employment status as predictors of treatment response in symptomatic individuals from the Bipolar Clinical Health Outcomes Initiative in Comparative Effectiveness (Bipolar CHOICE) study. It found that prior disability status was associated with a worse treatment response and prospective illness course.
AHRQ-funded; HS019371.
Citation: Deckersbach T, Nierenberg AA, McInnis MG .
Baseline disability and poor functioning in bipolar disorder predict worse outcomes: results from the Bipolar CHOICE study.
J Clin Psychiatry 2016 Jan;77(1):100-8. doi: 10.4088/JCP.14m09210.
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Keywords: Behavioral Health, Comparative Effectiveness, Patient-Centered Outcomes Research, Medication
Nierenberg AA, McElroy SL, Friedman ES
Bipolar CHOICE (Clinical Health Outcomes Initiative in Comparative Effectiveness): a pragmatic 6-month trial of lithium versus quetiapine for bipolar disorder.
The purpose of this trial was to compare lithium and second-generation antipsychotics. The investigators found that outcomes with lithium + APT and quetiapine + APT were not significantly different across 6 months of treatment for bipolar disorder.
AHRQ-funded; HS019371.
Citation: Nierenberg AA, McElroy SL, Friedman ES .
Bipolar CHOICE (Clinical Health Outcomes Initiative in Comparative Effectiveness): a pragmatic 6-month trial of lithium versus quetiapine for bipolar disorder.
J Clin Psychiatry 2016 Jan;77(1):90-9. doi: 10.4088/JCP.14m09349.
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Keywords: Adverse Drug Events (ADE), Comparative Effectiveness, Medication, Behavioral Health, Patient-Centered Outcomes Research
Kriegel LS, Henwood BF, Gilmer TP
Implementation and outcomes of forensic housing first programs.
The authors used administrative data and evaluative and qualitative site visit data to compare fidelity to the Housing First model and residential client outcomes between forensic and nonforensic programs and to investigate whether and how providers working in forensic programs can navigate competing Housing First principles and criminal justice mandates. They found that existing mental health and criminal justice collaborations necessitate adaptation to the Housing First model to accommodate client needs.
AHRQ-funded; HS018466.
Citation: Kriegel LS, Henwood BF, Gilmer TP .
Implementation and outcomes of forensic housing first programs.
Community Ment Health J 2016 Jan;52(1):46-55. doi: 10.1007/s10597-015-9946-5.
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Keywords: Healthcare Delivery, Behavioral Health, Vulnerable Populations
Patel SR, Gorritz M, Olfson M
Training community-based primary care physicians in the screening and management of mental health disorders among Latino primary care patients.
The researchers evaluated a quality improvement intervention to improve the screening and management (e.g., referral to psychiatric care) of common mental disorders in small independent Latino primary care practices. They concluded that improving the quality of mental health care in low-resourced primary care settings may require academic detailing and consultation/liaison psychiatric intervention supplemented with staff outreach to achieve meaningful improvement in the processes of care.
AHRQ-funded; HS021112.
Citation: Patel SR, Gorritz M, Olfson M .
Training community-based primary care physicians in the screening and management of mental health disorders among Latino primary care patients.
Gen Hosp Psychiatry 2016 Jan-Feb;38:71-8. doi: 10.1016/j.genhosppsych.2015.09.006.
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Keywords: Community-Based Practice, Primary Care, Behavioral Health, Racial and Ethnic Minorities, Quality Improvement
Amick HR, Gartlehner G, Gaynes BN
Comparative benefits and harms of second generation antidepressants and cognitive behavioral therapies in initial treatment of major depressive disorder: systematic review and meta-analysis.
This systematic review sought to identify the benefits and harms of second generation antidepressants and cognitive behavioral therapies (CBTs) in the initial treatment of a current episode of major depressive disorder in adults. It concluded that the available evidence suggests no difference in treatment effects of second generation antidepressants and CBT, either alone or in combination, although small numbers may preclude detection of small but clinically meaningful differences.
AHRQ-funded; 290-2012-00008I
Citation: Amick HR, Gartlehner G, Gaynes BN .
Comparative benefits and harms of second generation antidepressants and cognitive behavioral therapies in initial treatment of major depressive disorder: systematic review and meta-analysis.
BMJ 2015 Dec 8;351:h6019. doi: 10.1136/bmj.h6019..
Keywords: Medication, Behavioral Health, Comparative Effectiveness, Depression
Yu SH, Silverberg JI
Association between atopic dermatitis and depression in US adults.
The researchers sought to determine the prevalence of depression in US adults with atopic dermatitis (AD). They concluded that approximately one in three US adults with AD reported any symptoms of depression and one in three adults with AD met diagnostic criteria for major depressive disorder.
AHRQ-funded; HS023011.
Citation: Yu SH, Silverberg JI .
Association between atopic dermatitis and depression in US adults.
J Invest Dermatol 2015 Dec;135(12):3183-6. doi: 10.1038/jid.2015.337..
Keywords: Depression, Behavioral Health, Risk, Skin Conditions
Hamblin RJ, Lewin AB, Salloum A
Clinical characteristics and predictors of hoarding in children with anxiety disorders.
This investigation was conducted to describe the clinical characteristics of anxious children with significant hoarding behavior and to examine the contributions of anxiety, obsessive compulsive, and inattentive and hyperactive/impulsive symptoms in the prediction of hoarding. Its findings suggest a pattern of behavioral and emotional dysregulation for children who hoard and provide further insight into the relationships between anxiety, attention problems, and hoarding.
AHRQ-funded; HS018665.
Citation: Hamblin RJ, Lewin AB, Salloum A .
Clinical characteristics and predictors of hoarding in children with anxiety disorders.
J Anxiety Disord 2015 Dec;36:9-14. doi: 10.1016/j.janxdis.2015.07.006.
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Keywords: Children/Adolescents, Anxiety, Behavioral Health
Olfson M, Gerhard T, Huang C
Premature mortality among adults with schizophrenia in the United States.
The objective of the study was to describe overall and cause-specific mortality rates and standardized mortality ratios for adults with schizophrenia compared with the US general population. In a US national cohort of adults with schizophrenia, excess deaths from cardiovascular and respiratory diseases implicate modifiable cardiovascular risk factors, including especially tobacco use.
AHRQ-funded; HS021112.
Citation: Olfson M, Gerhard T, Huang C .
Premature mortality among adults with schizophrenia in the United States.
JAMA Psychiatry 2015 Dec;72(12):1172-81. doi: 10.1001/jamapsychiatry.2015.1737..
Keywords: Mortality, Behavioral Health, Patient-Centered Outcomes Research, Risk
Jones AL, Cochran SD, Leibowitz A
Usual primary care provider characteristics of a patient-centered medical home and mental health service use.
This study sought to examine qualities of a usual provider that align with the patient-centered medical home (PCMH) goals of access, comprehensiveness, and patient-centered care, It concluded that access to a usual provider is associated with increased receipt of needed mental health services. Patients who have a usual provider with PCMH qualities are more likely to receive mental health counseling.
AHRQ-funded; HS021721.
Citation: Jones AL, Cochran SD, Leibowitz A .
Usual primary care provider characteristics of a patient-centered medical home and mental health service use.
J Gen Intern Med 2015 Dec;30(12):1828-36. doi: 10.1007/s11606-015-3417-0.
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Keywords: Patient-Centered Healthcare, Behavioral Health, Primary Care
Mitchell SE, Martin JM, Krizman K
Design and rationale for a randomized controlled trial to reduce readmissions among patients with depressive symptoms.
This study aims to examine the effectiveness of RED-D, a modified brief Cognitive behavioral therapy (CBT) protocol delivered as a post-discharge extension of the Re-Engineered Discharge (RED), in reducing 30-day readmissions rates and emergency department use as well as depressive symptoms for medical patients with comorbid depressive symptoms.
AHRQ-funded; HS019700.
Citation: Mitchell SE, Martin JM, Krizman K .
Design and rationale for a randomized controlled trial to reduce readmissions among patients with depressive symptoms.
Contemp Clin Trials 2015 Nov;45(Pt B):151-6. doi: 10.1016/j.cct.2015.08.016.
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Keywords: Depression, Emergency Department, Hospital Discharge, Hospital Readmissions, Behavioral Health
Brent DA, Brunwasser SM, Hollon SD
Effect of a cognitive-behavioral prevention program on depression 6 years after implementation among at-risk adolescents: a randomized clinical trial.
The objective of this paper is to determine whether a cognitive-behavioral prevention (CBP) program reduced the incidence of depressive episodes, increased depression-free days, and improved developmental competence 6 years after implementation. Over the 75-month follow-up, youths assigned to CBP had a lower incidence of depression; the CBP program's overall significant effect was driven by a lower incidence of depressive episodes during the first 9 months after enrollment.
AHRQ-funded; HS022990.
Citation: Brent DA, Brunwasser SM, Hollon SD .
Effect of a cognitive-behavioral prevention program on depression 6 years after implementation among at-risk adolescents: a randomized clinical trial.
JAMA Psychiatry 2015 Nov;72(11):1110-8. doi: 10.1001/jamapsychiatry.2015.1559.
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Keywords: Behavioral Health, Children/Adolescents, Depression, Patient-Centered Outcomes Research
Olfson M, Wang S, Blanco C
National trends in hospital-treated self-harm events among middle-aged adults.
This study assessed national trends in hospital-treated self-harm events focusing on adults aged 45-64years. Between 2001 and 2011, there was a disproportionate national increase in hospital-treated self-harm events among middle-aged adults that mirrored national trends in suicide. The increase was largely accounted for by an overall increase in mental health hospitalizations of middle-aged adults.
AHRQ-funded; HS021112.
Citation: Olfson M, Wang S, Blanco C .
National trends in hospital-treated self-harm events among middle-aged adults.
Gen Hosp Psychiatry 2015 Nov-Dec;37(6):613-9. doi: 10.1016/j.genhosppsych.2015.08.004.
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Keywords: Healthcare Cost and Utilization Project (HCUP), Behavioral Health, Hospitalization
Epstein RA, Fonnesbeck C, Potter S
Psychosocial interventions for child disruptive behaviors: a meta-analysis.
The researchers conducted a systematic review and meta-analysis to synthesize existing literature on the comparative effectiveness of psychosocial interventions for children and adolescents, 18 years of age with disruptive behavior disorders. It concluded that the 3 intervention categories were more effective than the control conditions. Interventions with a parent component, either alone or in combination with other components, were likely to have the largest effect.
AHRQ-funded; 290201200009I.
Citation: Epstein RA, Fonnesbeck C, Potter S .
Psychosocial interventions for child disruptive behaviors: a meta-analysis.
Pediatrics 2015 Nov;136(5):947-60. doi: 10.1542/peds.2015-2577..
Keywords: Behavioral Health, Children/Adolescents, Comparative Effectiveness, Patient-Centered Outcomes Research