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AHRQ Research Studies
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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
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1 to 3 of 3 Research Studies DisplayedLee AK, Rawlings AM, Lee CJ
Severe hypoglycaemia, mild cognitive impairment, dementia and brain volumes in older adults with type 2 diabetes: the Atherosclerosis Risk in Communities (ARIC) cohort study.
In this study, the investigators aimed to evaluate the link between severe hypoglycaemia and domain-specific cognitive decline, smaller brain volumes and dementia in adults with type 2 diabetes. The investigators concluded that their results demonstrated a strong link between severe hypoglycaemia and poor cognitive outcomes, suggesting a need for discussion of appropriate diabetes treatments for high-risk older adults.
AHRQ-funded; HS018542.
Citation: Lee AK, Rawlings AM, Lee CJ .
Severe hypoglycaemia, mild cognitive impairment, dementia and brain volumes in older adults with type 2 diabetes: the Atherosclerosis Risk in Communities (ARIC) cohort study.
Diabetologia 2018 Sep;61(9):1956-65. doi: 10.1007/s00125-018-4668-1..
Keywords: Dementia, Diabetes, Elderly, Neurological Disorders, Risk
Mehta HB, Mehta V, Goodwin JS
Association of hypoglycemia with subsequent dementia in older patients with type 2 diabetes mellitus.
This study evaluated an association of hypoglycemia with subsequent dementia in patients with type 2 diabetes. Hypoglycemia is associated with a higher risk of dementia and may be responsible in part for the higher risk of dementia in patients with diabetes. Alternatively, hypoglycemia may be a marker for undiagnosed cognitive impairment, and we cannot rule out the possibility of reverse causation between hypoglycemia and dementia.
AHRQ-funded; HS022134.
Citation: Mehta HB, Mehta V, Goodwin JS .
Association of hypoglycemia with subsequent dementia in older patients with type 2 diabetes mellitus.
J Gerontol A Biol Sci Med Sci 2017 Aug;72(8):1110-16. doi: 10.1093/gerona/glw217.
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Keywords: Dementia, Diabetes, Elderly, Risk
Sarkar U, Lyles C, Steinman M
Changes in medication use after dementia diagnosis in an observational cohort of individuals with diabetes mellitus.
The researchers assessed changes in medication use after a diagnosis of dementia in individuals with type 2 diabetes mellitus. After adjustment, the number of chronic medications and the subset of cardiovascular medications declined after a dementia diagnosis in the overall cohort and in age-, sex-, and time-matched reference individuals, but the decline was significantly greater in the group with dementia.
AHRQ-funded; HS023558.
Citation: Sarkar U, Lyles C, Steinman M .
Changes in medication use after dementia diagnosis in an observational cohort of individuals with diabetes mellitus.
J Am Geriatr Soc 2017 Jan;65(1):77-82. doi: 10.1111/jgs.14429.
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Keywords: Medication, Diabetes, Dementia, Elderly, Healthcare Utilization