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AHRQ Research Studies
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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
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1 to 2 of 2 Research Studies DisplayedGinestra JC, Mitchell OJL, Anesi GL
COVID-19 critical illness: a data-driven review.
This paper is a data-driven review of COVID-19 critical illness, including the extreme demand for intensive care unit (ICU) resources and the rapidly evolving understanding of the disease. Almost one-third of hospitalized patients with COVID-19 experience critical illness. The most common type of organ failure experienced is acute hypoxic respiratory failure, which presents clinically as acute respiratory distress syndrome (ARDS) in three-quarters of ICU patients. Management of ARDS in COVID-19 patients is similar to that of non-COVID-19 ARDS patients. Mortality rates have decreased over the course of the pandemic likely due to increasing disease familiarity, data-driven pharmacologics, and improved adherence to evidence-based critical care.
AHRQ-funded; HS026372.
Citation: Ginestra JC, Mitchell OJL, Anesi GL .
COVID-19 critical illness: a data-driven review.
Annu Rev Med 2022 Jan 27;73:95-111. doi: 10.1146/annurev-med-042420-110629..
Keywords: COVID-19, Critical Care, Respiratory Conditions, Intensive Care Unit (ICU)
Gershengorn HB, Hu Y, Chen JT
The impact of high-flow nasal cannula use on patient mortality and the availability of mechanical ventilators in COVID-19.
This study looked at the effects of the use of high-flow nasal cannula for COVID-19 patients on mortality and the availability of mechanical ventilators. The authors constructed dynamical simulation models of high-flow nasal cannula and mechanical ventilation use in the United States. There were two outcomes looked for: 1) cumulative number of deaths; and 2) days without available ventilators. The strategy resulted in an estimated number of 10,000-40,000 fewer deaths than if high-flow nasal cannula were not available. This strategy also led up to 25 fewer days without available ventilators.
AHRQ-funded; HS026188.
Citation: Gershengorn HB, Hu Y, Chen JT .
The impact of high-flow nasal cannula use on patient mortality and the availability of mechanical ventilators in COVID-19.
Ann Am Thorac Soc 2021 Apr;18(4):623-31. doi: 10.1513/AnnalsATS.202007-803OC..
Keywords: COVID-19, Respiratory Conditions, Mortality, Critical Care