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Search All Research Studies
Topics
- Adverse Events (1)
- Alcohol Use (2)
- Behavioral Health (1)
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- (-) Diagnostic Safety and Quality (12)
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- Emergency Medical Services (EMS) (1)
- (-) Healthcare Cost and Utilization Project (HCUP) (12)
- Heart Disease and Health (2)
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- Injuries and Wounds (1)
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- Maternal Care (1)
- Medical Errors (1)
- Mortality (1)
- Patient Safety (2)
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- Sepsis (1)
- Stroke (1)
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- Women (1)
AHRQ Research Studies
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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
Results
1 to 12 of 12 Research Studies DisplayedNewman-Toker DE, Nassery N, Schaffer AC
Burden of serious harms from diagnostic error in the USA.
Americans who experience serious harm from misdiagnosis annually. Serious harm is defined as permanent morbidity or morality. This cross-sectional analysis used nationally representative observational data. The authors estimated annual incident vascular events and infections from 21.5 million (M) sampled US hospital discharges (2012-2014). US-based cancer registries were used to find annual new cancers. They derived diagnostic errors and serious harms by multiplying by literature-based rates for disease-specific incidences for 15 major vascular events, infections and cancers ('Big Three' categories). Extrapolating to all diseases (including non-'Big Three' dangerous disease categories), they estimated total serious harms annually in the USA to be 795,000 (plausible range 598,000-1,023,000). Using more conservative assumptions they estimated 549,000 serious harms. These results were compatible with setting-specific serious harm estimates from inpatient, emergency department and ambulatory care. Fifteen dangerous diseases accounted for 50.7% of total serious harms and the top 5 (stroke, sepsis, pneumonia, venous thromboembolism and lung cancer) accounted for 38.7%.
AHRQ-funded; HS027614; HS029350.
Citation: Newman-Toker DE, Nassery N, Schaffer AC .
Burden of serious harms from diagnostic error in the USA.
BMJ Qual Saf 2024 Jan 19; 33(2):109-20. doi: 10.1136/bmjqs-2021-014130..
Keywords: Healthcare Cost and Utilization Project (HCUP), Diagnostic Safety and Quality, Medical Errors, Patient Safety, Quality of Care, Adverse Events
Jordan Kempker A, Rudd KE, Wang HE
https://www.pubmed.ncbi.nlm.nih.gov/33009097
Sepsis epidemiology across the International Classification of Diseases, 9th Edition, to International Classification of Diseases, 10th Edition, chasm-a direct application of the Institute for Health Metrics and Evaluation case definition to hospital disc
The objective of this study was to describe the epidemiology of sepsis across the transition from the International Classification of Diseases (ICD), 9th Edition and ICD, 10th Edition, coding systems, evaluating estimates of two previously published ICD 10th Edition, coding strategies. The investigators concluded that The Institute for Health Metrics and Evaluation ICD, 10th Edition, coding strategy for identifying sepsis may capture a larger patient population within administrative datasets that are different from those identified with previously deployed ICD-based methods.
Citation: Jordan Kempker A, Rudd KE, Wang HE .
Sepsis epidemiology across the International Classification of Diseases, 9th Edition, to International Classification of Diseases, 10th Edition, chasm-a direct application of the Institute for Health Metrics and Evaluation case definition to hospital disc
Crit Care Med 2020 Dec;48(12):1881-84. doi: 10.1097/ccm.0000000000004577..
Keywords: Healthcare Cost and Utilization Project (HCUP), Sepsis, Diagnostic Safety and Quality
Salazar AS, Keller MR, Olsen MA
Potential missed opportunities for diagnosis of cryptococcosis and the association with mortality: a cohort study.
Cryptococcosis is one of the most common life-threatening opportunistic mycoses worldwide. Insidious presentation and slow onset of symptoms make it difficult to recognize, complicating the diagnostic process. Delays in diagnosis may lead to increased mortality. In this study, the investigators aimed to determine the frequency of missed opportunities for diagnosis of cryptococcosis and its effects on mortality.
AHRQ-funded; HS019455.
Citation: Salazar AS, Keller MR, Olsen MA .
Potential missed opportunities for diagnosis of cryptococcosis and the association with mortality: a cohort study.
EClinicalMedicine 2020 Oct 7;27:100563. doi: 10.1016/j.eclinm.2020.100563..
Keywords: Healthcare Cost and Utilization Project (HCUP), Diagnostic Safety and Quality, Mortality
Guglielminotti J, Rosenberg H, Li G
Prevalence of malignant hyperthermia diagnosis in obstetric patients in the United States, 2003 to 2014.
The goal of this study was to assess the prevalence of malignant hyperthermia (MH) diagnosis and associated factors in obstetric patients. Using data from the Nationwide Inpatient Sample, results showed that the prevalence of MH-susceptibility is about 1 in 125,000 in cesarean deliveries, similar to the prevalence reported in non-obstetrical surgery inpatients. The findings of this study suggest that stocking dantrolene in maternity units is justified.
AHRQ-funded; HS025787.
Citation: Guglielminotti J, Rosenberg H, Li G .
Prevalence of malignant hyperthermia diagnosis in obstetric patients in the United States, 2003 to 2014.
BMC Anesthesiol 2020 Jan 20;20(1):19. doi: 10.1186/s12871-020-0934-0..
Keywords: Healthcare Cost and Utilization Project (HCUP), Pregnancy, Maternal Care, Women, Diagnostic Safety and Quality, Labor and Delivery
Zins ZP, Wheeler KK, Brink F
Trends in US physician diagnosis of child physical abuse and neglect injuries, 2006-2014.
The purpose of this study was to determine if US child physical abuse and neglect injury rates changed from 2006 to 2014, whether definitive diagnoses of physical abuse and neglect were used more often over time, and what patient factors influenced definitive physical maltreatment diagnoses. The investigators found that definitive diagnoses of physical abuse and neglect increased over the study period and were associated with hospital volume and patient characteristics which may reflect provider experience and possible bias.
AHRQ-funded; HS024263.
Citation: Zins ZP, Wheeler KK, Brink F .
Trends in US physician diagnosis of child physical abuse and neglect injuries, 2006-2014.
Child Abuse Negl 2019 Dec;98:104179. doi: 10.1016/j.chiabu.2019.104179..
Keywords: Healthcare Cost and Utilization Project (HCUP), Children/Adolescents, Diagnostic Safety and Quality, Domestic Violence, Injuries and Wounds, Emergency Department, Hospitalization
Gray DT, Mizrahi T
AHRQ Author: Gray DT, Mizrahi T
Trends in appendicitis and perforated appendicitis prevalence in children in the United States, 2001-2015,
This cross-sectional study examined trends in appendicitis and perforated appendicitis in children in the United States from 2001 to 2015 using State Inpatient Databases (SIDS) HCUP data. Investigators found that rates of perforated appendicitis rose during that time period.
AHRQ-authored.
Citation: Gray DT, Mizrahi T .
Trends in appendicitis and perforated appendicitis prevalence in children in the United States, 2001-2015,
JAMA Netw Open 2020 Oct;3(10):e2023484. doi: 10.1001/jamanetworkopen.2020.23484..
Keywords: Healthcare Cost and Utilization Project (HCUP), Children/Adolescents, Diagnostic Safety and Quality
Heslin KC, Barrett ML
AHRQ Author: Heslin KC
Shifts in alcohol-related diagnoses after the introduction of International Classification of Diseases, Tenth Revision, clinical modification coding in U.S. hospitals: implications for epidemiologic research.
This study examined the impact of the ICD-10-CM coding system on estimates of hospital stays involving alcohol-related diagnoses. Using 2014 to 2017 HCUP data, results indicated that, on average, the number of stays involving any alcohol-related diagnosis in the 6 quarters before and after the ICD-10-CM transition was stable. However, substantial shifts in stays occurred for alcohol abuse, alcohol-induced mental disorders, and intoxication or toxic effects. Researchers conducting trend analyses of inpatient stays involving alcohol-related diagnoses should consider how ongoing modifications in the ICD-10-CM code system and coding guidelines might affect their work.
AHRQ-authored; AHRQ-funded.
Citation: Heslin KC, Barrett ML .
Shifts in alcohol-related diagnoses after the introduction of International Classification of Diseases, Tenth Revision, clinical modification coding in U.S. hospitals: implications for epidemiologic research.
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Keywords: Healthcare Cost and Utilization Project (HCUP), Alcohol Use, Diagnostic Safety and Quality, Substance Abuse
Heslin KC, Barrett ML
AHRQ Author: Heslin KC
Shifts in alcohol-related diagnoses after the introduction of International Classification of Diseases, Tenth Revision, clinical modification coding in U.S. hospitals: implications for epidemiologic research.
This study examined the impact of the ICD-10-CM coding system on estimates of hospital stays involving alcohol-related diagnoses. This analysis used 2014 to 2017 administrative data from the Agency for Healthcare Research and Quality Healthcare Cost and Utilization Project State Inpatient Databases for 17 states. The investigators found that on average, the number of stays involving any alcohol-related diagnosis in the 6 quarters before and after the ICD-10-CM transition was stable. However, substantial shifts in stays occurred for alcohol abuse, alcohol-induced mental disorders, and intoxication or toxic effects.
AHRQ-authored.
Citation: Heslin KC, Barrett ML .
Shifts in alcohol-related diagnoses after the introduction of International Classification of Diseases, Tenth Revision, clinical modification coding in U.S. hospitals: implications for epidemiologic research.
Alcohol Clin Exp Res 2018 Nov;42(11):2205-13. doi: 10.1111/acer.13866..
Keywords: Alcohol Use, Diagnostic Safety and Quality, Healthcare Cost and Utilization Project (HCUP), Substance Abuse
Egorova NN, Pincus HA, Shemesh E
Behavioral health diagnoses among children and adolescents hospitalized in the United States: observations and implications.
The study described rates and characteristics of U.S. children hospitalized with a behavioral (mental or substance use) disorder. The study concluded that nearly 500,000 pediatric admissions in 2012 included behavioral disorders. Comorbidities were associated with longer stays and an estimated $1.36 billion additional annual costs, which were disproportionately borne by public insurance.
AHRQ-funded; HS20518; HS024433.
Citation: Egorova NN, Pincus HA, Shemesh E .
Behavioral health diagnoses among children and adolescents hospitalized in the United States: observations and implications.
Psychiatr Serv 2018 Aug;69(8):910-18. doi: 10.1176/appi.ps.201700389..
Keywords: Behavioral Health, Children/Adolescents, Diagnostic Safety and Quality, Healthcare Cost and Utilization Project (HCUP)
Smith MW, Owens PL, Andrews RM
AHRQ Author: Owens PL, Andrews RM, Steiner CA
Differences in severity at admission for heart failure between rural and urban patients: the value of adding laboratory results to administrative data.
This study’s main objective was to examine the role of laboratory test results in measuring disease severity at the time of admission for inpatients who reside in rural and urban areas. It concluded that heart failure patients from rural areas are hospitalized at lower severity levels than their urban counterparts. Laboratory test data provide insight on clinical severity and practice patterns beyond what is available in administrative discharge data.
AHRQ-authored; AHRQ-funded; 29020060009.
Citation: Smith MW, Owens PL, Andrews RM .
Differences in severity at admission for heart failure between rural and urban patients: the value of adding laboratory results to administrative data.
BMC Health Serv Res 2016 Apr 18;16(1):133. doi: 10.1186/s12913-016-1380-z.
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Keywords: Heart Disease and Health, Hospitalization, Healthcare Cost and Utilization Project (HCUP), Diagnostic Safety and Quality, Rural Health
Moy E, Barrett M, Coffey R
AHRQ Author: Moy E
Missed diagnoses of acute myocardial infarction in the emergency department: variation by patient and facility characteristics.
The purpose of this study is to estimate the frequency of missed heart attacks or their precursors (e.g., unstable angina) in the emergency department (ED) by examining use of EDs in the week prior to hospitalization for heart attack. This study of 111,973 patients found an overall rate of 0.9 percent for missed diagnoses of heart attacks.
AHRQ-authored; AHRQ-funded; 290201300002C
Citation: Moy E, Barrett M, Coffey R .
Missed diagnoses of acute myocardial infarction in the emergency department: variation by patient and facility characteristics.
Diagn. 2015 Feb;2(1):29-40..
Keywords: Diagnostic Safety and Quality, Heart Disease and Health, Emergency Department, Emergency Medical Services (EMS), Healthcare Cost and Utilization Project (HCUP)
Newman-Toker DE, Moy E, Valente E
AHRQ Author: Moy E
Missed diagnosis of stroke in the emergency department: a cross-sectional analysis of a large population-based sample.
The authors sought to estimate the frequency of missed stroke and examine associations with patient, emergency department (ED), and hospital characteristics. They estimated 15,000-165,000 misdiagnosed cerebrovascular events annually in US EDs, disproportionately presenting with headache or dizziness. They recommended that physicians evaluating these symptoms be particularly attuned to the possibility of stroke in younger, female, and non-White patients.
AHRQ-authored; AHRQ-funded; HS019252.
Citation: Newman-Toker DE, Moy E, Valente E .
Missed diagnosis of stroke in the emergency department: a cross-sectional analysis of a large population-based sample.
Diagnosis 2014 Jun;1(2):155-66. doi: 10.1515/dx-2013-0038.
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Keywords: Diagnostic Safety and Quality, Emergency Department, Healthcare Cost and Utilization Project (HCUP), Patient Safety, Stroke