Yes. This is one of a number of actions that, per HHS grants policy, require awarding agency prior approval. The grantee must submit a written request to change the Principal Investigator (PI) of a grant. The request should include the effective date of the change, a justification for the change, qualifications of the proposed replacement PI, the curriculum vitae of the proposed replacement PI, level of effort to be committed by this individual, complete current Other Support for the proposed PI, and budgetary changes resulting from the proposed change. The request is to be signed by the departing PI (if possible), the proposed PI, and an authorized institutional official.
If the departing PI is to remain on the grant in any capacity, his or her new title and level of effort should be indicated as well as whether or not he or she will be acting in a key personnel capacity.
The grantee institution should submit this information to the Agency for Healthcare Research and Quality (AHRQ) as soon as possible, but no later than 30 days before the expected date of the original PI's departure.
Approval is not automatic. If AHRQ deems the proposed replacement PI unacceptable, the grantee may propose another individual. If an acceptable replacement cannot be found, the grant may have to be terminated.