Universal ICU Decolonization: An Enhanced Protocol

The REDUCE MRSA Trial (Randomized Evaluation of Decolonization vs. Universal Clearance to Eliminate Methicillin-Resistant Staphylococcus aureus) found that universal decolonization was the most effective intervention to reduce MRSA infections. This enhanced protocol provides instructions for implementing universal decolonization in adult intensive care units.

Prepared for:

Agency for Healthcare Research and Quality
Rockville, MD

Centers for Disease Control and Prevention
Atlanta, GA

Contract No. HHSA290201000008i

Prepared by:

The REDUCE MRSA Trial Working Group
Harvard Pilgrim Health Care
University of California Irvine
Hospital Corporation of America


Introduction and Welcome
Universal ICU Decolonization Protocol Overview
Scientific Rationale
Appendix A. Flow Chart for Implementing Universal Decolonization
Appendix B. Decisionmaking and Readiness for Implementation
Appendix C. Universal Decolonization in Adult ICUs Overview Statement
Appendix D. Universal ICU Decolonization Nursing Protocol
Appendix E. Training and Educational Materials
   Universal ICU Decolonization
   Universal ICU Decolonization Protocol for CHG Bathing
   Protocol Training
Appendix F. Chlorhexidine Bathing Skills Assessment
Appendix G. Safety and Adverse Events


University of California Irvine
Susan Huang, MD, MPH
Adrijana Gombosev, BS
Leah Terpstra, BA

Harvard Pilgrim Health Care
Richard Platt, MD, MS
Julie Lankiewicz, MPH, CCRC
Katie Haffenreffer, BS

Hospital Corporation of America (HCA)
Edward Septimus, MD
Jason Hickok, MBA, RN
Julia Moody, MS
Jonathan Perlin, MD, PhD

John Stronger Hospital of Cook County
Robert Weinstein, MD

Rush University
Mary Hayden, MD

Centers for Disease Control and Prevention
Jonathan Jernigan, MD, MPH

Preparation of this enhanced protocol was supported by the Agency for Healthcare Research and Quality (AHRQ) through contract HHSA290201000008i. The opinions presented herein are those of the authors and do not necessarily represent the position of the U.S. Department of Health and Human Services, AHRQ, or the Centers for Disease Control and Prevention (CDC).

This protocol is in the public domain and may be reproduced and distributed without permission. Citation as to source is appreciated.

Page last reviewed September 2013
Page originally created September 2013
Internet Citation: Universal ICU Decolonization: An Enhanced Protocol. Content last reviewed September 2013. Agency for Healthcare Research and Quality, Rockville, MD. https://www.ahrq.gov/hai/universal-icu-decolonization/index.html
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