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AHRQ Research Studies
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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
Results
4176 to 4200 of 12139 Research Studies DisplayedSmith JD, Rafferty MR, Heinemann AW
Pragmatic adaptation of implementation research measures for a novel context and multiple professional roles: a factor analysis study.
In this study, the investigators examined the internal consistency, factor structure, and structural invariance of four well-validated measures of inner setting factors across four groups of respondents. The items in these measures were adapted as part of an evaluation of a large-scale organizational change in a rehabilitation hospital, which involved transitioning to a new building and a new model of patient care, facilitated by a significant redesign of patient care and research spaces.
AHRQ-funded; HS025077.
Citation: Smith JD, Rafferty MR, Heinemann AW .
Pragmatic adaptation of implementation research measures for a novel context and multiple professional roles: a factor analysis study.
BMC Health Serv Res 2020 Mar 30;20(1):257. doi: 10.1186/s12913-020-05118-4..
Keywords: Implementation, Health Services Research (HSR), Organizational Change
Kohut MR, Keller SC, Linder JA
AHRQ Author: Miller MA
The inconvincible patient: how clinicians perceive demand for antibiotics in the outpatient setting.
Researchers conducted semi-structured interviews with clinicians to determine how they perceive demand for antibiotics in the outpatient setting. They conducted interviews with 25 clinicians from nine practices across three states. Patient demand was the most common reason why non-indicated antibiotics were prescribed. Clinicians felt that if they didn’t prescribe them they would experience repercussions in their reputation and practice and that certain patients are impossible to please without an antibiotic prescription regardless of the diagnosis.
AHRQ-authored; AHRQ-funded; 233201500020I.
Citation: Kohut MR, Keller SC, Linder JA .
The inconvincible patient: how clinicians perceive demand for antibiotics in the outpatient setting.
Fam Pract 2020 Mar 25;37(2):276-82. doi: 10.1093/fampra/cmz066..
Keywords: Antibiotics, Medication, Antimicrobial Stewardship, Ambulatory Care and Surgery, Provider: Clinician, Provider: Physician, Provider
Pokorney SD, Black-Maier E, Hellkamp AS
Oral anticoagulation and cardiovascular outcomes in patients with atrial fibrillation and end-stage renal disease.
The objective of this study was to describe patterns of oral anticoagulant (OAC) use in end-stage renal disease (ESRD) patients with atrial fibrillation (AF) and their associations with cardiovascular outcomes. Medicare fee-for-service 5% claims data from 2007 to 2013 was analyzed in a cohort of patients with ESRD and AF. A cohort of 8,410 patients with AF and ESRD was identified, with a total of 3,043 (36.2%) patients treated with OAC during the study period. Treatment with OAC was not associated with hospitalization for stroke, or death but was associated with increased hospitalization for bleeding and intracranial hemorrhage.
AHRQ-funded; HS021092.
Citation: Pokorney SD, Black-Maier E, Hellkamp AS .
Oral anticoagulation and cardiovascular outcomes in patients with atrial fibrillation and end-stage renal disease.
J Am Coll Cardiol 2020 Mar 24;75(11):1299-308. doi: 10.1016/j.jacc.2020.01.019..
Keywords: Blood Thinners, Medication, Heart Disease and Health, Cardiovascular Conditions, Kidney Disease and Health, Chronic Conditions, Outcomes
Garcia-Albeniz X, Hernan MA, Logan RW
Continuation of annual screening mammography and breast cancer mortality in women older than 70 years.
This study examined whether discontinuing annual mammography screening in women older than 70 years results in an increased 8-year breast cancer mortality. The researchers used data from the Medicare program and looked at over 1 million beneficiaries aged 70 to 84 who had no previous breast cancer diagnosis, and who underwent screening mammography from 2000 to 20008. The 8-year risk difference for women aged 70 to 74 years was -1.0 death per 1000 women and for women aged 75 to 84 years it was 0.07. Neither of these show substantial reductions in 8-year breast cancer mortality compared with stopping screening.
AHRQ-funded; HS023128.
Citation: Garcia-Albeniz X, Hernan MA, Logan RW .
Continuation of annual screening mammography and breast cancer mortality in women older than 70 years.
Ann Intern Med 2020 Mar 17;172(6):381-89. doi: 10.7326/m18-1199..
Keywords: Cancer: Breast Cancer, Cancer, Screening, Prevention, Women, Elderly, Mortality
Dobler CC, Morrow AS, Beuschel B
Pharmacologic therapies in patients with exacerbation of chronic obstructive pulmonary disease: a systematic review with meta-analysis.
The authors evaluated the comparative effectiveness and adverse events of pharmacologic interventions for adults with exacerbation of COPD. Sixty-eight randomized controlled trials were selected for evaluation and data extraction. They found that antibiotics and systemic corticosteroids reduced treatment failure in adults with mild to severe exacerbation of COPD.
AHRQ-funded.
Citation: Dobler CC, Morrow AS, Beuschel B .
Pharmacologic therapies in patients with exacerbation of chronic obstructive pulmonary disease: a systematic review with meta-analysis.
Ann Intern Med 2020 Mar 17;172(6):413-23. doi: 10.7326/m19-3007..
Keywords: Respiratory Conditions, Chronic Conditions, Evidence-Based Practice, Patient-Centered Outcomes Research, Comparative Effectiveness, Medication, Antibiotics, Treatments, Adverse Drug Events (ADE), Adverse Events
Rathi VK, McWilliams JM, Roberts ET
Rathi VK, McWilliams JM, Roberts ET. Getting incentives right in payment reform: thinking beyond financial risk.
In this paper the authors discuss payment reform, global budget models and why incentives differ for health system versus physician group ACO’s. They indicate that incentives in new payment models are closely connected to the structure of the health care delivery system and that policies that ignore this relationship and focus only on the risk terms of payment contracts may miss opportunities for progress.
AHRQ-funded; HS026727.
Citation: Rathi VK, McWilliams JM, Roberts ET .
Rathi VK, McWilliams JM, Roberts ET. Getting incentives right in payment reform: thinking beyond financial risk.
Ann Intern Med 2020 Mar 17;172(6):423-24. doi: 10.7326/m19-3178..
Keywords: Healthcare Costs, Policy, Payment
Fan T, Fakolade A
AHRQ Author: Fan T
Medication use to reduce risk of breast cancer.
In this case study, a 40-year-old woman comes to her doctor’s office for a routine gynecologic visit. She is not taking any medications and is generally healthy. She is sexually active, and her last menstrual period started 10 days ago. She states that her mother was diagnosed with bilateral breast cancer at 49 years of age and that she would like to discuss her options for reducing the risk of breast cancer. Three questions are posed about risk-reducing medications.
AHRQ-authored
Citation: Fan T, Fakolade A .
Medication use to reduce risk of breast cancer.
Am Fam Physician 2020 Mar 15;101(6):373-74..
Keywords: U.S. Preventive Services Task Force (USPSTF), Cancer: Breast Cancer, Cancer, Medication, Risk, Prevention, Case Study, Women
Fiscella K, Sanders M, Holder T
The role of data and safety monitoring boards in implementation trials: when are they justified?
This paper examined the appropriateness of the establishment of data and safety monitoring boards (DSMBs) for all phase III clinical trials sponsored by the National Heart, Lung and Blood Institute (NHLBI). The authors reviewed the unique features of implementation trials and reflected on key questions regarding the justification for DSMBs and their potential role and monitoring targets within implementation trials.
AHRQ-funded; HS021667.
Citation: Fiscella K, Sanders M, Holder T .
The role of data and safety monitoring boards in implementation trials: when are they justified?
J Clin Transl Sci 2020 Mar 5;4(3):229-32. doi: 10.1017/cts.2020.19..
Keywords: Research Methodologies, Implementation
Rangachari P, Dellsperger KC, Rethemeyer RK
A health system's pilot experience with using mobile Social Knowledge Networking (SKN) technology to enable meaningful Use of EHR medication reconciliation technology.
In fall 2016, a two-year grant was secured from AHRQ, to pilot a mobile Social Knowledge Networking (SKN) system on Electronic Health Record (EHR) Medication Reconciliation (MedRec), to enable Augusta University (AU) Health System, to progress from "limited-use" of EHR-MedRec technology, to "meaningful-use." This paper describes a health system's experiences with the pilot initiative; and discusses lessons learned, in regard to the potential of a mobile SKN system to enable Meaningful Use of EHR-MedRec technology.
AHRQ-funded; HS024335.
Citation: Rangachari P, Dellsperger KC, Rethemeyer RK .
A health system's pilot experience with using mobile Social Knowledge Networking (SKN) technology to enable meaningful Use of EHR medication reconciliation technology.
AMIA Annu Symp Proc 2020 Mar 4;2019:745-54..
Keywords: Electronic Health Records (EHRs), Health Information Technology (HIT), Medication
Corby S, Gold JA, Mohan V
A sociotechnical multiple perspectives approach to the use of medical scribes: a deeper dive into the scribe-provider interaction.
This study’s objective was examine the scribe-provider relationship at healthcare organizations. Scribes help providers with electronic health records to alleviate provider burnout and increase clinical efficiency. Participants in the study included 81 clinicians (30 providers, 27 scribes, and 24 administrators) across five sites. The analysis generated six subthemes: characteristics of an ideal scribe, characteristics of a good provider, provider variability, quality of the scribe-provider relationship, negative side of the relationship, and evaluation and supervision of scribes.
AHRQ-funded; HS025141.
Citation: Corby S, Gold JA, Mohan V .
A sociotechnical multiple perspectives approach to the use of medical scribes: a deeper dive into the scribe-provider interaction.
AMIA Annu Symp Proc 2020 Mar 4;2019:333-42..
Keywords: Burnout, Electronic Health Records (EHRs), Health Information Technology (HIT)
Marcial LH, Blumenfeld B, Harle C
Barriers, facilitators, and potential solutions to advancing interoperable clinical decision support: multi-stakeholder consensus recommendations for the opioid use case.
These proceedings report on the AHRQ-sponsored Patient-Centered CDS Learning Network (PCCDS LN) Technical Framework Working Group (TechFWG), which was convened to identify barriers, facilitators, and potential solutions for interoperable clinical decision support, with a specific focus on addressing the opioid epidemic. The key insights were extrapolated to CDS-facilitated care improvement outside of the specific opioid use case. If applied broadly, the recommendations should help advance the availability and impact of interoperable CDS delivered at scale.
AHRQ-funded; HS024849.
Citation: Marcial LH, Blumenfeld B, Harle C .
Barriers, facilitators, and potential solutions to advancing interoperable clinical decision support: multi-stakeholder consensus recommendations for the opioid use case.
AMIA Annu Symp Proc 2020 Mar 4;2019:637-46..
Keywords: Clinical Decision Support (CDS), Decision Making, Opioids, Medication, Pain, Patient-Centered Healthcare, Patient-Centered Outcomes Research
Sakaguchi-Tang DK, Turner AM, Taylor JO
Connected personas: translating the complexity of older adult personal health information management for designers of health information technologies.
HumanHuman-centered design (HCD) can be used to communicate research study findings to designers of health information technologies (HIT). In this paper, the investigators describe how they used the HCD approach to develop personas, scenarios, and design guidelines for designers with the aim that it would lead to new HIT designs that support the autonomy and health of older adults.
AHRQ-funded; HS022106.
Citation: Sakaguchi-Tang DK, Turner AM, Taylor JO .
Connected personas: translating the complexity of older adult personal health information management for designers of health information technologies.
AMIA Annu Symp Proc 2020 Mar 4;2019:1177-86..
Keywords: Elderly, Electronic Health Records (EHRs), Health Information Technology (HIT)
Rummo PE, Cassidy O, Wells I
Examining the relationship between youth-targeted food marketing expenditures and the demographics of social media followers.
The purpose of this study was to determine how many adolescents follow food/beverage brands on Instagram and Twitter, and examine associations between brands' youth-targeted marketing practices and percentages of adolescent followers. The investigators purchased data from Demographics Pro to characterize the demographics of Twitter and Instagram users who followed 27 of the most highly advertised fast food, snack, and drink brands in 2019. They found that food and sugary drink brands maintain millions of adolescent followers on social media.
AHRQ-funded; HS026120.
Citation: Rummo PE, Cassidy O, Wells I .
Examining the relationship between youth-targeted food marketing expenditures and the demographics of social media followers.
Int J Environ Res Public Health 2020 Mar 3;17(5). doi: 10.3390/ijerph17051631.
.
.
Keywords: Social Media, Children/Adolescents, Nutrition
Sprague BL, Coley RY, Kerlikowske K
Assessment of radiologist performance in breast cancer screening using digital breast tomosynthesis vs digital mammography.
Many US radiologists have screening mammography recall rates above the expert-recommended threshold of 12%. The influence of digital breast tomosynthesis (DBT) on the distribution of radiologist recall rates is uncertain. The objective of this study was to evaluate radiologists' recall and cancer detection rates before and after beginning interpretation of DBT examinations.
AHRQ-funded; HS018366.
Citation: Sprague BL, Coley RY, Kerlikowske K .
Assessment of radiologist performance in breast cancer screening using digital breast tomosynthesis vs digital mammography.
JAMA Netw Open 2020 Mar 2;3(3):e201759. doi: 10.1001/jamanetworkopen.2020.1759..
Keywords: Cancer: Breast Cancer, Cancer, Diagnostic Safety and Quality, Imaging, Screening, Women, Prevention, Provider Performance
Banzett RBB, Sheridan AR, Baker KM
'Scared to death' dyspnoea from the hospitalised patient's perspective.
The authors collected patients' descriptions of dyspnea in their own words during a parent study in which 156 hospitalized patients completed a quantitative multidimensional dyspnea questionnaire. These volunteered comments provided insights not conveyed by structured rating scales. The researchers organized these comments into the most prominent themes, which included sensory experiences, emotional responses, self-blame, and precipitating events. Patients often mentioned air hunger, anxiety, and fear. Patients' own words can help to bridge the gap of understanding.
AHRQ-funded; HS024288.
Citation: Banzett RBB, Sheridan AR, Baker KM .
'Scared to death' dyspnoea from the hospitalised patient's perspective.
BMJ Open Respir Res 2020 Mar;7(1). doi: 10.1136/bmjresp-2019-000493..
Keywords: Respiratory Conditions, Clinician-Patient Communication, Communication
Whiteside SPH, Sim LA, Morrow AS
A meta-analysis to guide the enhancement of CBT for childhood anxiety: exposure over anxiety management.
Cognitive behavior therapy (CBT) is the most empirically supported therapy for childhood anxiety disorders (CADs) but has not reliably outperformed other credible interventions. The current study used meta-analysis to examine the frequency with which the most common treatment components are included in outcome studies and the relation of these components to symptom improvement.
AHRQ-funded; 290201500013I.
Citation: Whiteside SPH, Sim LA, Morrow AS .
A meta-analysis to guide the enhancement of CBT for childhood anxiety: exposure over anxiety management.
Clin Child Fam Psychol Rev 2020 Mar;23(1):102-21. doi: 10.1007/s10567-019-00303-2..
Keywords: Children/Adolescents, Anxiety, Behavioral Health, Treatments, Patient-Centered Outcomes Research, Evidence-Based Practice
Taft L, Shen C
A non-parametric statistical test of null treatment effect in sub-populations.
Randomized clinical trials are designed to estimate the average treatment effect (ATE). If heterogeneity of treatment effect exists, then it is possible that there may be subjects who derive a treatment effect different from the ATE. In this study, the investigators propose a method to test the hypothesis that there exist subjects who derive benefit (or harm) against the null hypothesis that the treatment has no benefit (or harm) on each of the smallest sub-populations defined by discrete baseline covariates.
AHRQ-funded; HS024520.
Citation: Taft L, Shen C .
A non-parametric statistical test of null treatment effect in sub-populations.
J Biopharm Stat 2020 Mar;30(2):277-93. doi: 10.1080/10543406.2019.1636810..
Keywords: Research Methodologies, Patient-Centered Outcomes Research
Pereira T, Gadhoumi K, Ma M
A supervised approach to robust photoplethysmography quality assessment.
In this paper, the investigators tested the performance of algorithms selected from a body of studies on photoplethysmogram (PPG) quality assessment using a dataset of PPG recordings from patients with AFib. They then proposed machine learning approaches for PPG quality assessment in 30-s segments of PPG recording from 13 stroke patients admitted to the University of California San Francisco (UCSF) neuro intensive care unit and another dataset of 3764 patients from one of the five UCSF general intensive care units.
AHRQ-funded; HS022860.
Citation: Pereira T, Gadhoumi K, Ma M .
A supervised approach to robust photoplethysmography quality assessment.
IEEE J Biomed Health Inform 2020 Mar;24(3):649-57. doi: 10.1109/jbhi.2019.2909065..
Keywords: Heart Disease and Health, Cardiovascular Conditions, Stroke, Diagnostic Safety and Quality
Popejoy LL, Vogelsmeier AA, Wakefield BJ
Adapting Project RED to skilled nursing facilities.
This article described the investigator recommendations for adapting hospital-based RED (Reengineered Discharge) processes to skilled nursing facilities (SNFs). Using focus groups, the SNFs' discharge processes were assessed twice additionally, research staff then recorded field notes documenting discussions about facility discharge processes as they related to RED processes. Data were systematically analyzed using thematic analysis to identify recommendations for adapting RED to the SNF setting.
AHRQ-funded; HS022140.
Citation: Popejoy LL, Vogelsmeier AA, Wakefield BJ .
Adapting Project RED to skilled nursing facilities.
Clin Nurs Res 2020 Mar;29(3):149-56. doi: 10.1177/1054773818819261..
Keywords: Nursing Homes, Elderly, Transitions of Care, Patient-Centered Healthcare
Berdahl T, Biener A, McCormick MC
AHRQ Author: Berdahl T
Annual report on children's healthcare: healthcare access and utilization by obesity status in the United States.
This study examined access to care and utilization patterns across a set of healthcare measures by obesity status and sociodemographic characteristics among children. Data from the Medical Expenditure Panel Survey (MEPS) from 2010-2015 was used to determine obesity status, number of well-child visits, access to a usual source of care, number of preventive dental visits and prescription medication fills in the past year. It was found that uninsured adolescents with obesity were less like to have a usual source of care provider than children without obesity. Among younger children, those living in the Northeast were more than twice as likely to have had a well-child visit than those living in the West. Preventive dental care was less likely to have occurred for children with obesity than non-obese children. More prescription refills were completed for obese adolescents than for younger children.
AHRQ-authored.
Citation: Berdahl T, Biener A, McCormick MC .
Annual report on children's healthcare: healthcare access and utilization by obesity status in the United States.
Acad Pediatr 2020 Mar;20(2):175-87. doi: 10.1016/j.acap.2019.11.020..
Keywords: Medical Expenditure Panel Survey (MEPS), Children/Adolescents, Access to Care, Healthcare Utilization, Obesity
Ho V, Metcalfe L, Vu L
Annual spending per patient and quality in hospital-owned versus physician-owned organizations: an observational study.
This study examined whether there are patient spending differences between practices owned by hospitals versus independent physician practices. The study used data from patients aged 19 to 64 enrolled in a Blue Cross Blue Shield Preferred Provider organization in the four largest metropolitan areas in Texas. Spending was found to be significantly higher for durable medical equipment, imaging, unclassified services, and outpatient care in hospital-owned practices. Estimates were that expenses were 5.8% higher in those practices.
AHRQ-funded; HS024727.
Citation: Ho V, Metcalfe L, Vu L .
Annual spending per patient and quality in hospital-owned versus physician-owned organizations: an observational study.
J Gen Intern Med 2020 Mar;35(3):649-55. doi: 10.1007/s11606-019-05312-z..
Keywords: Hospitals, Healthcare Costs, Quality of Care
Chatterjee S, Bali V, Carnahan RM
Anticholinergic burden and risk of cognitive impairment in elderly nursing home residents with depression.
This study evaluated whether elderly nursing home residents with mild depression and intact cognition experienced cognitive impairment after using anticholinergic drugs. The study was a population-based nested case-control study using Minimum Data Set (MDS)-linked Medicare data where the base cohort were patients 65 years and older with depression who had intact cognition. Cumulative anticholinergic burden was measured within 30, 60, and 90 days preceding the event (cognitive measurement) date using the Anticholinergic Drug Scale (ADS). The end sample compared 3707 cases with mild-to-moderate cognition to 3707 matched controls with intact cognition. There was no association with cumulative anticholinergic exposure at 30 days with cognitive impairment, but the odds of cognitive impairment increased with exposure 60 and 90 days before the event date. This study concludes there should be concern in using anticholinergic drugs for longer than 30 days with elderly nursing home residents.
AHRQ-funded; HS021264.
Citation: Chatterjee S, Bali V, Carnahan RM .
Anticholinergic burden and risk of cognitive impairment in elderly nursing home residents with depression.
Res Social Adm Pharm 2020 Mar;16(3):329-35. doi: 10.1016/j.sapharm.2019.05.020..
Keywords: Elderly, Nursing Homes, Long-Term Care, Depression, Behavioral Health, Medication, Neurological Disorders, Adverse Drug Events (ADE), Adverse Events, Patient Safety
Basciotta M, Zhou W, Ngo L
Antipsychotics and the risk of mortality or cardiopulmonary arrest in hospitalized adults.
Investigators sought to evaluate the risk of death or nonfatal cardiopulmonary arrest in hospitalized adults exposed to antipsychotics. They found that, in hospitalized adults, typical antipsychotics were associated with increased mortality or cardiopulmonary arrest, whereas atypical antipsychotics were only associated with increased risk among adults age 65 years and older. They recommended that providers be thoughtful when prescribing antipsychotic medications, especially to older adults in settings where data regarding benefit are lacking.
AHRQ-funded; HS026215.
Citation: Basciotta M, Zhou W, Ngo L .
Antipsychotics and the risk of mortality or cardiopulmonary arrest in hospitalized adults.
J Am Geriatr Soc 2020 Mar;68(3):544-50. doi: 10.1111/jgs.16246..
Keywords: Medication, Risk, Hospitalization, Cardiovascular Conditions, Mortality, Elderly
Sun CJ, Seloilwe ES, Magowe M
Association of adolescent- and parent-reported relationship functioning with HIV sexual risk among adolescents in Botswana.
Globally, adolescents in sub-Saharan Africa are the youth most affected by HIV. Parent-adolescent relationships can be protective in child and adolescent development and may be implicated in lowered adolescent HIV sexual risk. This dyadic study simultaneously assessed both parents' and adolescents' perceptions of family functioning and their relationships with adolescent sexual behaviors in Botswana.
AHRQ-funded; HS022981.
Citation: Sun CJ, Seloilwe ES, Magowe M .
Association of adolescent- and parent-reported relationship functioning with HIV sexual risk among adolescents in Botswana.
AIDS Behav 2020 Mar;24(3):975-83. doi: 10.1007/s10461-019-02429-4..
Keywords: Children/Adolescents, Human Immunodeficiency Virus (HIV), Risk, Sexual Health
Shaheen MS, Silverberg JI
Association of asthma with osteopenia, osteoporosis, osteomalacia, and fractures.
Previous studies that examined the relationship between asthma, osteoporosis, and pathologic fractures found conflicting results. The objective of this study was to determine whether asthma was associated with osteopenia, osteoporosis, osteomalacia, and fractures in U.S. adults. The investigators concluded that ED visits with asthma were associated with osteopenia, osteoporosis, osteomalacia, and pathologic fractures.
Citation: Shaheen MS, Silverberg JI .
Association of asthma with osteopenia, osteoporosis, osteomalacia, and fractures.
Allergy Asthma Proc 2020 Mar 1;41(2):112-19. doi: 10.2500/aap.2020.41.190035.
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Keywords: Healthcare Cost and Utilization Project (HCUP), Osteoporosis, Injuries and Wounds, Emergency Department