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AHRQ Research Studies
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Research Studies is a compilation of published research articles funded by AHRQ or authored by AHRQ researchers.
Results
11951 to 11975 of 12392 Research Studies DisplayedKlann JG, Buck MD, Brown J
Query Health: standards-based, cross-platform population health surveillance.
The Office of the National Coordinator for Health Information Technology (ONC) Query Health Initiative is a collaboration to develop a national architecture for distributed, population-level health queries across diverse clinical systems with disparate data models. The authors review Query Health activities, including a standards-based methodology, an open-source reference implementation, and three pilot projects.
AHRQ-funded; HS019912.
Citation: Klann JG, Buck MD, Brown J .
Query Health: standards-based, cross-platform population health surveillance.
J Am Med Inform Assoc. 2014 Jul-Aug;21(4):650-6. doi: 10.1136/amiajnl-2014-002707..
Keywords: Public Health, Education: Patient and Caregiver, Health Information Technology (HIT)
Lyerly MJ, Houston JT, Boehme AK
Safety of intravenous tissue plasminogen activator administration with computed tomography evidence of prior infarction.
The researchers sought to determine if the presence of a previous stroke on pretreatment computed tomography (CT) is a predictor of hemorrhagic complications and functional outcomes after the administration of intravenous (IV) tissue plasminogen activator (tPA). Their data suggest that a prior stroke on CT should not be viewed as a reason to withhold this treatment unless it occurred within the last 3 months.
AHRQ-funded; HS013852.
Citation: Lyerly MJ, Houston JT, Boehme AK .
Safety of intravenous tissue plasminogen activator administration with computed tomography evidence of prior infarction.
J Stroke Cerebrovasc Dis 2014 Jul;23(6):1657-61. doi: 10.1016/j.jstrokecerebrovasdis.2014.01.011..
Keywords: Stroke, Risk, Outcomes, Imaging
Lee GJ, Dotson JL, Kappelman MD
Seasonality and pediatric inflammatory bowel disease.
The researchers sought to determine whether disease activity in pediatric-onset inflammatory bowel disease (IBD) is associated with a seasonal pattern. Studying 1325 patients with Crohn disease and 587 patients with ulcerative colitis, their findings do not support any strong associations between season of the year and disease activity in pediatric IBD.
AHRQ-funded; HS020024.
Citation: Lee GJ, Dotson JL, Kappelman MD .
Seasonality and pediatric inflammatory bowel disease.
J Pediatr Gastroenterol Nutr 2014 Jul;59(1):25-8. doi: 10.1097/mpg.0000000000000362.
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Keywords: Children/Adolescents, Digestive Disease and Health, Children/Adolescents
Gadzinski AJ, Dimick JB, Ye Z
Transfer rates and use of post-acute care after surgery at critical access vs non-critical access hospitals.
This study evaluated discharge practice patterns and use of post-acute care after surgical admissions at critical access hospitals (CAHs). It found that for each of six common surgical procedures, a greater proportion of patients was transferred to another hospital. However, the proportion of patients at CAHs using post-acute care is equal to or less than that of patients treated in non-CAHs.
AHRQ-funded; HS018346
Citation: Gadzinski AJ, Dimick JB, Ye Z .
Transfer rates and use of post-acute care after surgery at critical access vs non-critical access hospitals.
JAMA Surg. 2014 Jul;149(7):671-7. doi: 10.1001/jamasurg.2013.5694..
Keywords: Surgery, Critical Care, Hospital Discharge, Quality of Care
Cottrell EK, O'Brien K, Curry M
Understanding safety in prehospital emergency medical services for children.
This paper adds to the qualitative understanding of the nature of and contributors to safety events in the prehospital emergency care of children. The findings of this study suggest that factors at the systems, team, child/family, and individual provider level system contribute to errors in prehospital emergency care. These factors may be modifiable through interventions and systems improvements.
AHRQ-funded; HS019456.
Citation: Cottrell EK, O'Brien K, Curry M .
Understanding safety in prehospital emergency medical services for children.
Prehosp Emerg Care 2014 Jul-Sep;18(3):350-8. doi: 10.3109/10903127.2013.869640.
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Keywords: Care Management, Children/Adolescents, Emergency Medical Services (EMS), Quality of Care, Patient Safety
Arora VM, Berhie S, Horwitz LI
Using standardized videos to validate a measure of handoff quality: the handoff mini-clinical examination exercise.
The researchers report the results of the development of a shorter Handoff Mini-Clinical Examination Exercise (CEX), along with the formal establishment of its construct validity, namely its ability to distinguish between levels of performance in 3 domains of handoff quality. They were able to demonstrate evidence that the Handoff Mini-CEX can draw reliable and valid conclusions regarding handoff performance by physicians in U.S. hospitals.
AHRQ-funded; HS018278
Citation: Arora VM, Berhie S, Horwitz LI .
Using standardized videos to validate a measure of handoff quality: the handoff mini-clinical examination exercise.
J Hospital Med. 2014 Jul;9(7):441-6. doi: 10.1002/jhm.2185.
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Keywords: Provider Performance, Quality Measures, Quality Improvement, Quality of Care, Education: Continuing Medical Education, Patient Safety
Hsieh YH, Haukoos JS, Rothman RE
Validation of an abbreviated version of the Denver HIV Risk Score for prediction of HIV infection in an urban ED.
The researchers sought to evaluate the performance of a short version of the Denver HIV Risk Score in 2 urban emergency departments. They found that external validation resulted in good discrimination. The study cohort included 15,184 patients with newly diagnosed HIV infection.
AHRQ-funded; HS017526
Citation: Hsieh YH, Haukoos JS, Rothman RE .
Validation of an abbreviated version of the Denver HIV Risk Score for prediction of HIV infection in an urban ED.
Am J Emerg Med. 2014 Jul;32(7):775-9. doi: 10.1016/j.ajem.2014.02.043..
Keywords: Emergency Medical Services (EMS), Human Immunodeficiency Virus (HIV), Risk, Urban Health
Kumamaru H, Judd SE, Curtis JR
Validity of claims-based stroke algorithms in contemporary Medicare data: reasons for geographic and racial differences in stroke (REGARDS) study linked with medicare claims.
The researchers assessed the validity of diagnostic coding algorithms for identifying stroke in the Medicare population by linking data from the REasons for Geographic And Racial Differences in Stroke (REGARDS) Study to Medicare claims. They found that claims-based algorithms to identify stroke in a contemporary Medicare cohort had high positive predictive value and specificity, supporting their use as outcomes for etiologic and comparative effectiveness studies in similar populations.
AHRQ-funded; HS017731; HS018517.
Citation: Kumamaru H, Judd SE, Curtis JR .
Validity of claims-based stroke algorithms in contemporary Medicare data: reasons for geographic and racial differences in stroke (REGARDS) study linked with medicare claims.
Circ Cardiovasc Qual Outcomes 2014 Jul;7(4):611-9. doi: 10.1161/circoutcomes.113.000743..
Keywords: Stroke, Medicare, Comparative Effectiveness, Outcomes
Singh JA
The impact of gout on patient's lives: a study of African-American and Caucasian men and women with gout.
The objectives of this study were to assess the impact of gout on patients’ quality of life (QOL) and explore gender and race differences in the impact of gout on patients’ QOL. Some frequently cited high-ranked concerns among the ten nominal race- and sex-stratified groups were: (1) effect of gout flare on daily activities (n = 10 groups); (2) work disability (n = 8 groups);and (3) severe pain (n = 8 groups).
AHRQ-funded; HS021110.
Citation: Singh JA .
The impact of gout on patient's lives: a study of African-American and Caucasian men and women with gout.
Arthritis Res Ther 2014 Jun 24;16(3):R132. doi: 10.1186/ar4589..
Keywords: Quality of Life, Social Determinants of Health, Racial and Ethnic Minorities
Kaplan RM
AHRQ Author: Kaplan RM
Patient-centered outcome assessment may lead to different conclusions and different treatment decisions.
Over the last few decades, the Agency for Healthcare Research and Quality (AHRQ), clinicians, policy makers, and patient advocates have demonstrated a growing interest in measuring patient-reported outcomes. Most illnesses are now evaluated in terms of their effects on usual life activities. This article discusses Patient-Centered Outcomes Research and the measurement of outcomes from the patient perspective.
AHRQ-authored.
Citation: Kaplan RM .
Patient-centered outcome assessment may lead to different conclusions and different treatment decisions.
American Journal of Accountable Care 2014 Jun 20;2(2):14-15..
Keywords: Shared Decision Making, Patient-Centered Outcomes Research
Ekwueme DU, Yabroff KR, Guy GP, Jr.
AHRQ Author: Soni A, Davidoff A
Medical costs and productivity losses of cancer survivors--United States, 2008-2011.
In order to estimate annual medical costs and productivity losses among male and female cancer survivors and persons without a cancer history, the CDC, along with other organizations, analyzed data from the 2008-2011 Medical Expenditure Panel Survey (MEPS) and found that the economic burden of cancer survivorship is substantial among all survivors. These findings identified a need to develop and evaluate health and employment intervention programs aimed at improving outcomes for cancer survivors and their families.
AHRQ-authored.
Citation: Ekwueme DU, Yabroff KR, Guy GP, Jr. .
Medical costs and productivity losses of cancer survivors--United States, 2008-2011.
MMWR Morb Mortal Wkly Rep 2014 Jun 13;63(23):505-10.
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Keywords: Cancer, Healthcare Costs, Medical Expenditure Panel Survey (MEPS)
Padula WV, Mishra MK, Makic MB
A framework of quality improvement interventions to implement evidence-based practices for pressure ulcer prevention.
The purpose of this paper is to enhance the learner’s competence with knowledge about a framework of quality improvement (QI) interventions to implement evidence-based practices for pressure ulcer (PrU) prevention. The best-practice framework offers a reference point to initiating a bundle of QI interventions in support of evidence-based practices. Hospitals and clinicians tasked with quality improvement efforts can use this framework to problem-solve PrU prevention and other critical issues.
AHRQ-funded; HS023710.
Citation: Padula WV, Mishra MK, Makic MB .
A framework of quality improvement interventions to implement evidence-based practices for pressure ulcer prevention.
Adv Skin Wound Care 2014 Jun;27(6):280-4; quiz 85-6. doi: 10.1097/01.ASW.0000450703.87099.5b..
Keywords: Quality Improvement, Patient Safety, Evidence-Based Practice, Pressure Ulcers, Guidelines
Gagne JJ, Wang SV, Rassen JA
A modular, prospective, semi-automated drug safety monitoring system for use in a distributed data environment.
The purpose of this study was to develop and test a semi-automated process for conducting routine active safety monitoring for new drugs in a network of electronic health care databases. The system identified serious risks due to some drugs, which were eventually removed from the market years later.
AHRQ-funded; HS018088; HS022193
Citation: Gagne JJ, Wang SV, Rassen JA .
A modular, prospective, semi-automated drug safety monitoring system for use in a distributed data environment.
Pharmacoepidemiol Drug Saf. 2014 Jun;23(6):619-27. doi: 10.1002/pds.3616..
Keywords: Medication: Safety, Health Information Technology (HIT), Patient Safety, Medication
Zhang Y, Zhou C, Baik SH
A simple change to the Medicare Part D low-income subsidy program could save $5 billion.
The authors used an intelligent reassignment algorithm and 2008-09 Medicare Part D drug use and spending data to match enrollees to available Part D plans according to their medication needs. They found that such a reassignment approach, compared to the current approach, could have saved the federal government over $5 billion in 2009.
AHRQ-funded; HS018657.
Citation: Zhang Y, Zhou C, Baik SH .
A simple change to the Medicare Part D low-income subsidy program could save $5 billion.
Health Aff 2014 Jun;33(6):940-5. doi: 10.1377/hlthaff.2013.1083.
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Keywords: Healthcare Costs, Low-Income, Medicare, Medication
Weiss JM, Schumacher J, Allen GO
Adjuvant chemotherapy for stage II right-sided and left-sided colon cancer: analysis of SEER-medicare data.
The researchers examined the relationship between adjuvant chemotherapy and overall 5-year mortality for stage II colon cancer by location (right- vs. left-side) as a surrogate for microsatellite instability which is more common in right-sided cancers. They found that the chemotherapy did not improve survival for either right- or left-sided cancers.
AHRQ-funded; HS000083
Citation: Weiss JM, Schumacher J, Allen GO .
Adjuvant chemotherapy for stage II right-sided and left-sided colon cancer: analysis of SEER-medicare data.
Ann Surg Oncol. 2014 Jun;21(6):1781-91. doi: 10.1245/s10434-014-3631-8..
Keywords: Mortality, Treatments
Schmid CH, Trikalinos Olkin, I
Bayesian network meta-analysis for unordered categorical outcomes with incomplete data.
The researchers developed a Bayesian multinomial network meta-analysis model for unordered (nominal) categorical outcomes that allows for partially observed data in which exact event counts may not be known for each category. Their model properly accounts for correlations of counts in mutually exclusive categories and enables proper comparison and ranking of treatment effects across multiple treatments and multiple outcomes categories.
AHRQ-funded; HS018574.
Citation: Schmid CH, Trikalinos Olkin, I .
Bayesian network meta-analysis for unordered categorical outcomes with incomplete data.
Res Synth Methods 2014 Jun;5(2):162-85. doi: 10.1002/jrsm.1103..
Keywords: Comparative Effectiveness, Outcomes, Data
Forrester SH, Hepp Z, Roth JA
Cost-effectiveness of a computerized provider order entry system in improving medication safety ambulatory care.
The study objective was to estimate the cost-effectiveness of computerized provider order entry versus traditional paper-based prescribing in reducing medications errors and adverse drug events in the ambulatory setting of mid-sized medical group. Using a decision-analytic model, the researchers found that the adoption of CPOE in the ambulatory setting provides excellent value for the investment.
AHRQ-funded; HS014739
Citation: Forrester SH, Hepp Z, Roth JA .
Cost-effectiveness of a computerized provider order entry system in improving medication safety ambulatory care.
Value Health. 2014 Jun;17(4):340-9. doi: 10.1016/j.jval.2014.01.009..
Keywords: Health Information Technology (HIT), Adverse Drug Events (ADE), Adverse Events, Medical Errors, Medication, Patient Safety, Healthcare Costs, Ambulatory Care and Surgery, Prevention
Schweizer ML, Cullen JJ, Perencevich EN
Costs associated with surgical site infections in Veterans Affairs hospitals.
This study evaluated surgical site infections(SSIs) in 1,756 Veterans Administration patients to determine the excess costs associated with total, deep, and superficial SSIs. It found that the highest risk-adjusted costs occurred with deep SSIs and SSIs associated with neurosurgery patients.
AHRQ-funded; HS021992
Citation: Schweizer ML, Cullen JJ, Perencevich EN .
Costs associated with surgical site infections in Veterans Affairs hospitals.
JAMA Surg. 2014 Jun;149(6):575-581. doi:10.1001/jamasurg.2013.4663..
Keywords: Surgery, Healthcare-Associated Infections (HAIs), Patient Safety, Healthcare Costs
Bilimoria KY, Cella D, Butt Z
Current challenges in using patient-reported outcomes for surgical care and performance measurement: everybody wants to hear from the patient, but are we ready to listen?
This viewpoint article discussed patient-reported outcomes (PROs). It concludes that PROs undoubtedly capture some of the most important aspects of how successful an operation is, and PRO scores may be the best measure of patient-centered care, but considerable logistical and methodological issues must be addressed before PROs are ready for widespread national implementation.
AHRQ-funded; HS021857.
Citation: Bilimoria KY, Cella D, Butt Z .
Current challenges in using patient-reported outcomes for surgical care and performance measurement: everybody wants to hear from the patient, but are we ready to listen?
JAMA Surg 2014 Jun;149(6):505-6. doi: 10.1001/jamasurg.2013.5285.
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Keywords: Patient-Centered Outcomes Research, Quality Measures, Surgery
Voils CI, Gierisch JM, Yancy WS, Jr.
Differentiating behavior initiation and maintenance: theoretical framework and proof of concept.
The authors posited that health behavior initiation and maintenance require separate psychological processes and skills. They found evidence of improvement in dietary intake and of maintenance of physical activity and low-density lipoprotein cholesterol during the 4-month maintenance study. Participants found it helpful to plan for relapses, self-monitor, and obtain social support, but they had mixed reactions about reflecting on satisfaction with outcomes.
AHRQ-funded; HS000079.
Citation: Voils CI, Gierisch JM, Yancy WS, Jr. .
Differentiating behavior initiation and maintenance: theoretical framework and proof of concept.
Health Educ Behav 2014 Jun;41(3):325-36. doi: 10.1177/1090198113515242.
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Keywords: Nutrition, Patient Adherence/Compliance, Patient Self-Management, Lifestyle Changes
Sorkin DH, Mavandadi S, Rook KS
AHRQ Author: Ngo-Metzger Q
Dyadic collaboration in shared health behavior change: the effects of a randomized trial to test a lifestyle intervention for high-risk Latinas.
The authors sought to evaluate the feasibility of a pilot, dyad-based lifestyle intervention, the Unidas por la Vida program, for improving weight loss and dietary intake among high-risk Mexican American mothers with Type 2 diabetes and their overweight/obese adult daughters. They found that, at 16 weeks, Unidas participants lost significantly more weight compared with the control participants, and intervention participants also were more likely to be eating foods with lower glycemic load and less saturated fat. They concluded that interventions that draw upon multiple people who share a health-risk have the potential to foster significant changes in lifestyle behaviors and in social network members' health-related involvement.
AHRQ-authored.
Citation: Sorkin DH, Mavandadi S, Rook KS .
Dyadic collaboration in shared health behavior change: the effects of a randomized trial to test a lifestyle intervention for high-risk Latinas.
Health Psychol 2014 Jun;33(6):566-75. doi: 10.1037/hea0000063.
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Keywords: Diabetes, Lifestyle Changes, Obesity, Racial and Ethnic Minorities, Obesity: Weight Management
Bobo WV, Reilly-Harrington NA, Ketter TA
Effect of adjunctive benzodiazepines on clinical outcomes in lithium- or quetiapine-treated outpatients with bipolar I or II disorder: results from the Bipolar CHOICE trial.
This study investigated the longer-term effects of adjunctive benzodiazepines on symptom response during treatment in patients with bipolar disorders. The investigators concluded that adjunctive benzodiazepines may not significantly affect clinical outcome in lithium- or quetiapine-treated patients with bipolar I or II disorder over 6 months, after controlling for potential confounding factors.
AHRQ-funded; HS019371.
Citation: Bobo WV, Reilly-Harrington NA, Ketter TA .
Effect of adjunctive benzodiazepines on clinical outcomes in lithium- or quetiapine-treated outpatients with bipolar I or II disorder: results from the Bipolar CHOICE trial.
J Affect Disord 2014 Jun;161:30-5. doi: 10.1016/j.jad.2014.02.046..
Keywords: Comparative Effectiveness, Depression, Medication, Behavioral Health, Treatments
Tong L, Ahn C, Symanski E
Effects of newly developed chemotherapy regimens, comorbidities, chemotherapy-related toxicities on the changing patterns of the leading causes of death in elderly patients with colorectal cancer.
This study examined the effects of newly developed chemotherapy regimens, comorbidities, and chemotherapy-related toxicities on the changing patterns of the leading causes of death in elderly patients with colorectal cancer (CRC). It found that the risks of CRC-specific death decreased with diagnostic time periods only in chemotherapy recipients.
AHRQ-funded; HS018956
Citation: Tong L, Ahn C, Symanski E .
Effects of newly developed chemotherapy regimens, comorbidities, chemotherapy-related toxicities on the changing patterns of the leading causes of death in elderly patients with colorectal cancer.
Ann Oncol. 2014 Jun;25(6):1234-42. doi: 10.1093/annonc/mdu131..
Keywords: Elderly, Mortality, Treatments, Medicare
Darney BG, Caughey AB
Elective induction of labor symposium: nomenclature, research methodological issues, and outcomes.
This article focuses on key method issues in studies of elective induction of labor. The authors first identify methodological concerns with the existing literature and discuss each in return. They then review existing evidence about the relationship between elective induction and cesarean delivery.
AHRQ-funded; HS017582
Citation: Darney BG, Caughey AB .
Elective induction of labor symposium: nomenclature, research methodological issues, and outcomes.
Clin Obstet Gynecol. 2014 Jun;57(2):343-62. doi: 10.1097/GRF.0000000000000029..
Keywords: Research Methodologies, Outcomes, Labor and Delivery, Women
Wang CY, Graham JE, Karmarkar AM
FIM motor scores for classifying community discharge after inpatient rehabilitation for hip fracture.
A major goal of this study was to identify which discharge functional independence measure (FIM)--total, motor, or cognition--best discriminates community versus institutional discharges. It found that the FIM motor scale yields the best overall discrimination of patients discharged to the community versus those discharged to an institution after inpatient rehabilitation for hip fracture.
AHRQ-funded; HS022134.
Citation: Wang CY, Graham JE, Karmarkar AM .
FIM motor scores for classifying community discharge after inpatient rehabilitation for hip fracture.
PM & R 2014 Jun; 6(6):493-7. doi: 10.1016/j.pmrj.2013.12.008..
Keywords: Hospital Discharge, Injuries and Wounds, Elderly